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Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2015)
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FGF21 increases water intake, urine output and blood pressure in rats
Turner, Tod, Chen, Xian, Zahner, Matthew, Opsahl, Alan, DeMarco, George, Boucher, Magalie, Goodwin, Bryan, Perreault, Mylène
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Published in PloS one (14.08.2018)
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EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model
Rhodin, Michael H J, McAllister, Nicole V, Castillo, Jonathan, Noton, Sarah L, Fearns, Rachel, Kim, In Jong, Yu, Jianming, Blaisdell, Thomas P, Panarese, Joseph, Shook, Brian C, Or, Yat Sun, Goodwin, Bryan, Lin, Kai
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Published in PLoS pathogens (15.03.2021)
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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Published in Cell metabolism (01.10.2005)
Published in Cell metabolism (01.10.2005)
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The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
Rhodin, Michael H J, Reyes, Archie C, Balakrishnan, Anand, Bisht, Nalini, Kelly, Nicole M, Gibbons, Joyce Sweeney, Lloyd, Jonathan, Vaine, Michael, Cressey, Tessa, Crepeau, Miranda, Shen, Ruichao, Manalo, Nathan, Castillo, Jonathan, Levene, Rachel E, Leonard, Daniel, Zang, Tianzhu, Jiang, Lijuan, Daniels, Kellye, Cox, Robert M, Lieber, Carolin M, Wolf, Josef D, Plemper, Richard K, Leist, Sarah R, Scobey, Trevor, Baric, Ralph S, Wang, Guoqiang, Goodwin, Bryan, Or, Yat Sun
Published in Nature communications (01.08.2024)
Published in Nature communications (01.08.2024)
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Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver
Hall, Angela M., Kou, Kou, Chen, Zhouji, Pietka, Terri A., Kumar, Mrudula, Korenblat, Kevin M., Lee, Kyuha, Ahn, Kay, Fabbrini, Elisa, Klein, Samuel, Goodwin, Bryan, Finck, Brian N.
Published in Journal of lipid research (01.05.2012)
Published in Journal of lipid research (01.05.2012)
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
Liu, Yaping, Binz, Jane, Numerick, Mary Jo, Dennis, Steve, Luo, Guizhen, Desai, Bhasha, MacKenzie, Kathleen I, Mansfield, Traci A, Kliewer, Steven A, Goodwin, Bryan, Jones, Stacey A
Published in The Journal of clinical investigation (01.12.2003)
Published in The Journal of clinical investigation (01.12.2003)
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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity
Cao, Jingsong, Perez, Sylvie, Goodwin, Bryan, Lin, Qingcong, Peng, Haibing, Qadri, Ariful, Zhou, Yingjiang, Clark, Ronald W, Perreault, Mylene, Tobin, James F, Gimeno, Ruth E
Published in American journal of physiology: endocrinology and metabolism (15.05.2014)
Published in American journal of physiology: endocrinology and metabolism (15.05.2014)
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Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
Maglich, Jodi M, Stoltz, Catherine M, Goodwin, Bryan, Hawkins-Brown, Diane, Moore, John T, Kliewer, Steven A
Published in Molecular pharmacology (01.09.2002)
Published in Molecular pharmacology (01.09.2002)
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Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes
Lee, Darwin V, Li, Dongmei, Yan, Qingyun, Zhu, Yimin, Goodwin, Bryan, Calle, Roberto, Brenner, Martin B, Talukdar, Saswata
Published in PloS one (03.11.2014)
Published in PloS one (03.11.2014)
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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
Holt, Jason A, Luo, Guizhen, Billin, Andrew N, Bisi, John, McNeill, Y Yvette, Kozarsky, Karen F, Donahee, Mary, Wang, Da Yuan, Mansfield, Traci A, Kliewer, Steven A, Goodwin, Bryan, Jones, Stacey A
Published in Genes & development (01.07.2003)
Published in Genes & development (01.07.2003)
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Regulation of cyp3a gene transcription by the pregnane x receptor
Goodwin, Bryan, Redinbo, Matthew R, Kliewer, Steven A
Published in Annual review of pharmacology and toxicology (01.01.2002)
Published in Annual review of pharmacology and toxicology (01.01.2002)
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
Liu, Yaping, Binz, Jane, Numerick, Mary Jo, Dennis, Steve, Luo, Guizhen, Desai, Bhasha, MacKenzie, Kathleen I., Mansfield, Traci A., Kliewer, Steven A., Goodwin, Bryan, Jones, Stacey A.
Published in The Journal of clinical investigation (01.12.2003)
Published in The Journal of clinical investigation (01.12.2003)
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Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor
Kast, Heidi R., Goodwin, Bryan, Tarr, Paul T., Jones, Stacey A., Anisfeld, Andrew M., Stoltz, Catherine M., Tontonoz, Peter, Kliewer, Steve, Willson, Timothy M., Edwards, Peter A.
Published in The Journal of biological chemistry (25.01.2002)
Published in The Journal of biological chemistry (25.01.2002)
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The Nuclear Receptor PXR is a Lithocholic Acid Sensor That Protects against Liver Toxicity
Staudinger, Jeff L., Goodwin, Bryan, Jones, Stacey A., Hawkins-Brown, Diane, MacKenzie, Kathleen I., LaTour, Anne, Liu, Yaping, Klaassen, Curtis D., Brown, Kathleen K., Reinhard, John, Willson, Timothy M., Koller, Beverly H., Kliewer, Steven A.
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2001)
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