Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4
Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Journal Article
Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases
Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Journal Article
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N
Published in Science translational medicine (07.11.2012)
Published in Science translational medicine (07.11.2012)
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Journal Article
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)
Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
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Journal Article
NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation
Gatto, Gregory J., Ao, Zhaohui, Kearse, Michael G., Zhou, Mei, Morales, Cyndi R., Daniels, Erin, Bradley, Benjamin T., Goserud, Matthew T., Goodman, Krista B., Douglas, Stephen A., Harpel, Mark R., Johns, Douglas G.
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
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Journal Article
Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors
Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Journal Article
Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magnetic Resonance Imaging Assessment
Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2010)
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Journal Article
Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity
Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Journal Article
Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors
Goodman, Krista B., Bury, Michael J., Cheung, Mui, Cichy-Knight, Maria A., Dowdell, Sarah E., Dunn, Allison K., Lee, Dennis, Lieby, Jeffrey A., Moore, Michael L., Scherzer, Daryl A., Sha, Deyou, Suarez, Dominic P., Murphy, Dennis J., Harpel, Mark R., Manas, Eric S., McNulty, Dean E., Annan, Roland S., Matico, Rosalie E., Schwartz, Benjamin K., Trill, John J., Sweitzer, Thomas D., Wang, Da-yuan, Keller, Paul M., Krawiec, John A., Jaye, Michael C.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood
Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Journal Article
Aminomethylpiperazines as selective urotensin antagonists
Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
Development of potent and selective small-molecule human Urotensin-II antagonists
McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Journal Article
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles
McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
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Journal Article
NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
GOODMAN KRISTA B, KRAUSS ACHIM HANS PETER, DODIC NERINA, LE MONNIER DE GOUVILLE ANNE CHARLOTTE
Year of Publication 17.05.2016
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Year of Publication 17.05.2016
Patent
TRPV4 ANTAGONISTS
GOODMAN KRISTA B, BROOKS CARL, STOY PATRICK, CHEUNG MUI, HOANG TRAM H, HILFIKER MARK A, YE GUOSEN, HAMMOND MARLYS, PATTERSON JACLYN R, EIDAM HILARY SCHENCK
Year of Publication 04.04.2014
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Year of Publication 04.04.2014
Patent
Novel soluble guanylate cyclase activators and their use
Krauss, Achim Hans-Peter, Le Monnier De Gouville, Anne-Charlotte, Goodman, Krista B, Dodic, Nerina
Year of Publication 24.08.2017
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Year of Publication 24.08.2017
Patent
Novel soluble guanylate cyclase activators and their use
Krauss, Achim Hans-Peter, Le Monnier De Gouville, Anne-Charlotte, Goodman, Krista B, Dodic, Nerina
Year of Publication 20.07.2017
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Year of Publication 20.07.2017
Patent