Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4
Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Risk factors for disease progression in idiopathic pulmonary fibrosis
Raghu, Ganesh, Ley, Brett, Brown, Kevin K, Cottin, Vincent, Gibson, Kevin F, Kaner, Robert J, Lederer, David J, Noble, Paul W, Song, Jin Woo, Wells, Athol U, Whelan, Timothy P, Lynch, David A, Humphries, Stephen M, Moreau, Emmanuel, Goodman, Krista, Patterson, Scott D, Smith, Victoria, Gong, Qi, Sundy, John S, O'Riordan, Thomas G, Martinez, Fernando J
Published in Thorax (01.01.2020)
Published in Thorax (01.01.2020)
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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)
Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
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1433 Targeting peptidyl-prolyl isomerase Pin1 to modulate cancer-associated fibroblast phenotype and TGF-beta signaling
Chow, Melvyn, O’Shea, Morgan, Tasdemir, Doga, Starobinets, Hanna, Brown, Kristin, Sabatos-Peyton, Catherine, Corse, Emily, Hayes, Sebastian, Goodman, Krista
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation
Gatto, Gregory J., Ao, Zhaohui, Kearse, Michael G., Zhou, Mei, Morales, Cyndi R., Daniels, Erin, Bradley, Benjamin T., Goserud, Matthew T., Goodman, Krista B., Douglas, Stephen A., Harpel, Mark R., Johns, Douglas G.
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N
Published in Science translational medicine (07.11.2012)
Published in Science translational medicine (07.11.2012)
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Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases
Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Journal Article
Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors
Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magnetic Resonance Imaging Assessment
Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2010)
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Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity
Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood
Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Aminomethylpiperazines as selective urotensin antagonists
Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Development of potent and selective small-molecule human Urotensin-II antagonists
McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Journal Article
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles
McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
Published in Bioorganic & medicinal chemistry letters (01.07.2008)
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Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors
Goodman, Krista B., Bury, Michael J., Cheung, Mui, Cichy-Knight, Maria A., Dowdell, Sarah E., Dunn, Allison K., Lee, Dennis, Lieby, Jeffrey A., Moore, Michael L., Scherzer, Daryl A., Sha, Deyou, Suarez, Dominic P., Murphy, Dennis J., Harpel, Mark R., Manas, Eric S., McNulty, Dean E., Annan, Roland S., Matico, Rosalie E., Schwartz, Benjamin K., Trill, John J., Sweitzer, Thomas D., Wang, Da-yuan, Keller, Paul M., Krawiec, John A., Jaye, Michael C.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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ZUMA-8: A phase 1/2 multicenter study evaluating KTE-X19 in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
Flinn, Ian, Marris, Michael, Wierda, William G., Coutre, Steven, Pagel, John M., Byrd, John C., Goyal, Lovely, Goodman, Krista, Zheng, Yan, Milletti, Francesca, Murugappan, Swaminathan, Brown, Jennifer R.
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Relation of Childhood Sexual Abuse, Intimate Partner Violence, and Depression to Risk Factors for HIV Among Black Men Who Have Sex With Men in 6 US Cities
Williams, John K, Wilton, Leo, Magnus, Manya, Wang, Lei, Wang, Jing, Dyer, Typhanye Penniman, Koblin, Beryl A, Hucks-Ortiz, Christopher, Fields, Sheldon D, Shoptaw, Steve, Stephenson, Rob, O'Cleirigh, Conall, Cummings, Vanessa
Published in American journal of public health (1971) (01.12.2015)
Published in American journal of public health (1971) (01.12.2015)
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Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo
Xu, Xiaoping, Goyal, Navin, Costell, Melissa H, Roethke, Theresa, James, Christian H, Thorneloe, Kevin S, Patterson, Jaclyn, Stoy, Patrick, Goodman, Krista, Sprecher, Dennis L, Behm, David J
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
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Abstract 5574: Degradation of PIP4K2C by novel bivalent functional degrader LRK-A induces tumor regression in CRC
Corse, Emily, Goodman, Krista, O'Shea, Morgan, Ye, Guosen, Chow, Melvyn, Arnold, Julie, Giacalone, Vincent, Hayes, Sebastian, Dube, Erica, Alnemy, Sydney, Adigun, Oluwatimileyin Akinrinmade, Brown, Kristin, d'Hennezel, Eva, Sabatos-Peyton, Catherine
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Engaging, recruiting, and retaining black men who have sex with men in research studies: don't underestimate the importance of staffing--lessons learned from HPTN 061, the BROTHERS study
Magnus, Manya, Franks, Julie, Griffith, Sam, Arnold, Michael P, Goodman, Krista, Wheeler, Darrell P
Published in Journal of public health management and practice (01.11.2014)
Published in Journal of public health management and practice (01.11.2014)
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