Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B‑Cell Lymphomas
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Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Molecular Shape and Medicinal Chemistry: A Perspective
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Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Discovery, design, and synthesis of indole-based EZH2 inhibitors
Gehling, Victor S., Vaswani, Rishi G., Nasveschuk, Christopher G., Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C., Campbell, Robert, Lee, Christina, Dakin, Les A., Cook, Andrew S., Gagnon, Alexandre, Harmange, Jean-Christophe, Audia, James E., Cummings, Richard T., Normant, Emmanuel, Trojer, Patrick, Albrecht, Brian K.
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor
Zheng, Barbara, D’Andrea, Stanley V, Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Yan, Hrnciar, Peter, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Yu, Fei, Sheaffer, Amy K, Knipe, Jay O, Mosure, Kathy, Rajamani, Ramkumar, Good, Andrew C, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Paruchuri, Manjula, Ng, Alicia, Gao, Qi, Rampulla, Richard A, Mathur, Arvind, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M
Published in ACS medicinal chemistry letters (08.02.2018)
Published in ACS medicinal chemistry letters (08.02.2018)
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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor
Venables, Brian L., Sin, Ny, Wang, Alan Xiangdong, Sun, Li-Qiang, Tu, Yong, Hernandez, Dennis, Sheaffer, Amy, Lee, Min, Dunaj, Cindy, Zhai, Guangzhi, Barry, Diana, Friborg, Jacques, Yu, Fei, Knipe, Jay, Sandquist, Jason, Falk, Paul, Parker, Dawn, Good, Andrew C., Rajamani, Ramkumar, McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors
Gehling, Victor S., Mcgrath, John P., Duplessis, Martin, Khanna, Avinash, Brucelle, Francois, Vaswani, Rishi G., Cote, Alexandre, Stuckey, Jacob, Watson, Venita, Cummings, Richard T., Balasubramanian, Srividya, Iyer, Priya, Sawant, Priyanka, Good, Andrew C., Albrecht, Brian K., Harmange, Jean-Christophe, Audia, James E., Bellon, Steven F., Trojer, Patrick, Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design
Good, Andrew C, Liu, Jinyu, Hirth, Bradford, Asmussen, Gary, Xiang, Yibin, Biemann, Hans-Peter, Bishop, Kimberly A, Fremgen, Trisha, Fitzgerald, Maria, Gladysheva, Tatiana, Jain, Annuradha, Jancsics, Katherine, Metz, Markus, Papoulis, Andrew, Skerlj, Renato, Stepp, J. David, Wei, Ronnie R
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Gerritz, Samuel W, Zhai, Weixu, Shi, Shuhao, Zhu, Shirong, Toyn, Jeremy H, Meredith, Jere E, Iben, Lawrence G, Burton, Catherine R, Albright, Charles F, Good, Andrew C, Tebben, Andrew J, Muckelbauer, Jodi K, Camac, Daniel M, Metzler, William, Cook, Lynda S, Padmanabha, Ramesh, Lentz, Kimberley A, Sofia, Michael J, Poss, Michael A, Macor, John E, Thompson, Lorin A
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus
Wang, Alan Xiangdong, Chen, Jie, Zhao, Qian, Sun, Li-Qiang, Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Good, Andrew C., Klei, Herbert E., Rajamani, Ramkumar, Mosure, Kathy, Knipe, Jay O., Li, Danshi, Zhu, Jialong, Levesque, Paul C., McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons
Belema, Makonen, Nguyen, Van N., Romine, Jeffrey L., St. Laurent, Denis R., Lopez, Omar D., Goodrich, Jason T., Nower, Peter T., O’Boyle, Donald R., Lemm, Julie A., Fridell, Robert A., Gao, Min, Fang, Hua, Krause, Rudolph G., Wang, Ying-Kai, Oliver, A. Jayne, Good, Andrew C., Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
Boy, Kenneth M., Guernon, Jason M., Wu, Yong-Jin, Zhang, Yunhui, Shi, Joe, Zhai, Weixu, Zhu, Shirong, Gerritz, Samuel W., Toyn, Jeremy H., Meredith, Jere E., Barten, Donna M., Burton, Catherine R., Albright, Charles F., Good, Andrew C., Grace, James E., Lentz, Kimberley A., Olson, Richard E., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies
Lopez, Omar D, Nguyen, Van N, St. Laurent, Denis R, Belema, Makonen, Serrano-Wu, Michael H, Goodrich, Jason T, Yang, Fukang, Qiu, Yuping, Ripka, Amy S, Nower, Peter T, Valera, Lourdes, Liu, Mengping, O’Boyle, Donald R., II, Sun, Jin-Hua, Fridell, Robert A, Lemm, Julie A, Gao, Min, Good, Andrew C, Meanwell, Nicholas A, Snyder, Lawrence B
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives
Belema, Makonen, Nguyen, Van N., St. Laurent, Denis R., Lopez, Omar D., Qiu, Yuping, Good, Andrew C., Nower, Peter T., Valera, Lourdes, O’Boyle, Donald R., Sun, Jin-Hua, Liu, Mengping, Fridell, Robert A., Lemm, Julie A., Gao, Min, Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
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