Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
Fitzgerald, Kevin, Dr, Frank-Kamenetsky, Maria, PhD, Shulga-Morskaya, Svetlana, MSc, Liebow, Abigail, BS, Bettencourt, Brian R, PhD, Sutherland, Jessica E, PhD, Hutabarat, Renta M, PhD, Clausen, Valerie A, PhD, Karsten, Verena, PhD, Cehelsky, Jeffrey, MBA, Nochur, Saraswathy V, PhD, Kotelianski, Victor, MD, Horton, Jay, MD, Mant, Timothy, MD, Chiesa, Joseph, MD, Ritter, James, MD, Munisamy, Malathy, MD, Vaishnaw, Akshay K, MD, Gollob, Jared A, MD, Simon, Amy, MD
Published in The Lancet (British edition) (04.01.2014)
Published in The Lancet (British edition) (04.01.2014)
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randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
DeVincenzo, John, Lambkin-Williams, Robert, Wilkinson, Tom, Cehelsky, Jeffrey, Nochur, Sara, Walsh, Edward, Meyers, Rachel, Gollob, Jared, Vaishnaw, Akshay
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2010)
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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
Zimmermann, Tracy S., Karsten, Verena, Chan, Amy, Chiesa, Joseph, Boyce, Malcolm, Bettencourt, Brian R., Hutabarat, Renta, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared
Published in Molecular therapy (04.01.2017)
Published in Molecular therapy (04.01.2017)
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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients
Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS
Published in The Journal of heart and lung transplantation (01.02.2016)
Published in The Journal of heart and lung transplantation (01.02.2016)
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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial
Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.
Published in Nature medicine (01.12.2023)
Published in Nature medicine (01.12.2023)
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Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study
Suhr, Ole B, Coelho, Teresa, Buades, Juan, Pouget, Jean, Conceicao, Isabel, Berk, John, Schmidt, Hartmut, Waddington-Cruz, Márcia, Campistol, Josep M, Bettencourt, Brian R, Vaishnaw, Akshay, Gollob, Jared, Adams, David
Published in Orphanet journal of rare diseases (04.09.2015)
Published in Orphanet journal of rare diseases (04.09.2015)
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Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study
Adams, David, Coelho, Teresa, Obici, Laura, Merlini, Giampaolo, Mincheva, Zoia, Suanprasert, Narupat, Bettencourt, Brian R, Gollob, Jared A, Gandhi, Pritesh J, Litchy, William J, Dyck, Peter J
Published in Neurology (25.08.2015)
Published in Neurology (25.08.2015)
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RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus
ZAMORA, Martin R, BUDEV, Marie, GOLLOB, Jared A, GLANVILLE, Allan R, ROLFE, Mark, GOTTLIEB, Jens, HUMAR, Atul, DEVINCENZO, John, VAISHNAW, Akshay, CEHELSKY, Jeffrey, ALBERT, Gary, NOCHUR, Sara
Published in American journal of respiratory and critical care medicine (15.02.2011)
Published in American journal of respiratory and critical care medicine (15.02.2011)
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Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy
Adams, David, Suhr, Ole B, Dyck, Peter J, Litchy, William J, Leahy, Raina G, Chen, Jihong, Gollob, Jared, Coelho, Teresa
Published in BMC neurology (11.09.2017)
Published in BMC neurology (11.09.2017)
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First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
Tabernero, Josep, Shapiro, Geoffrey I, LoRusso, Patricia M, Cervantes, Andres, Schwartz, Gary K, Weiss, Glen J, Paz-Ares, Luis, Cho, Daniel C, Infante, Jeffrey R, Alsina, Maria, Gounder, Mrinal M, Falzone, Rick, Harrop, Jamie, White, Amy C Seila, Toudjarska, Iva, Bumcrot, David, Meyers, Rachel E, Hinkle, Gregory, Svrzikapa, Nenad, Hutabarat, Renta M, Clausen, Valerie A, Cehelsky, Jeffrey, Nochur, Saraswathy V, Gamba-Vitalo, Christina, Vaishnaw, Akshay K, Sah, Dinah W Y, Gollob, Jared A, Burris, 3rd, Howard A
Published in Cancer discovery (01.04.2013)
Published in Cancer discovery (01.04.2013)
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A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis
Coelho, Teresa, Adams, David, Conceição, Isabel, Waddington-Cruz, Márcia, Schmidt, Hartmut H, Buades, Juan, Campistol, Josep, Berk, John L, Polydefkis, Michael, Wang, Jing Jing, Chen, Jihong, Sweetser, Marianne T, Gollob, Jared, Suhr, Ole B
Published in Orphanet journal of rare diseases (08.07.2020)
Published in Orphanet journal of rare diseases (08.07.2020)
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Phase II Trial of Sorafenib Plus Interferon Alfa-2b As First- or Second-Line Therapy in Patients With Metastatic Renal Cell Cancer
GOLLOB, Jared A, KIMRYN RATHMELL, W, RICHMOND, Tina M, MARINO, Christine B, MILLER, Elizabeth K, GRIGSON, Gayle, WATKINS, Catharine, LIN GU, PETERSON, Bercedis L, WRIGHT, John J
Published in Journal of clinical oncology (01.08.2007)
Published in Journal of clinical oncology (01.08.2007)
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Safety, Pharmacokinetics, and Activity of ABX-EGF, a Fully Human Anti–Epidermal Growth Factor Receptor Monoclonal Antibody in Patients With Metastatic Renal Cell Cancer
ROWINSKY, Eric K, SCHWARTZ, Garry H, ARENAS, Rosalin, FOON, Kenneth A, SCHWAB, Gisela, DUTCHER, Janice, GOLLOB, Jared A, THOMPSON, John A, VOGELZANG, Nicholas J, FIGLIN, Robert, BUKOWSKI, Ronald, HAAS, Naomi, LOCKBAUM, Pamela, LI, Yu-Ping
Published in Journal of clinical oncology (01.08.2004)
Published in Journal of clinical oncology (01.08.2004)
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Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma
GOLLOB, Jared A, SCIAMBI, Catherine J, PETERSON, Bercedis L, RICHMOND, Tina, THORESON, Monica, MORAN, Kelly, DRESSMAN, Holly K, JELINEK, Jaroslav, ISSA, Jean-Pierre J
Published in Clinical cancer research (01.08.2006)
Published in Clinical cancer research (01.08.2006)
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Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells
Niemietz, Christoph J, Sauer, Vanessa, Stella, Jacqueline, Fleischhauer, Lutz, Chandhok, Gursimran, Guttmann, Sarah, Avsar, Yesim, Guo, Shuling, Ackermann, Elizabeth J, Gollob, Jared, Monia, Brett P, Zibert, Andree, Schmidt, Hartmut H-J
Published in PloS one (01.09.2016)
Published in PloS one (01.09.2016)
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603 Targeted STAT3 degradation leads to remodeling of an immunosuppressive tumor microenvironment and subsequent sensitization to immune checkpoint therapy
Dey, Joyoti, Liu, Phillip, Mayo, Michele, Karnik, Rahul, Yang, Bin, Dixit, Vaishali, Jeong, Jieun, Gollob, Jared, Savi, Chris De
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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