Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, Maccormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R
Published in Nature chemical biology (13.04.2011)
Published in Nature chemical biology (13.04.2011)
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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA
Swan, Michael K., Legris, Valerie, Tanner, Adam, Reaper, Philip M., Vial, Sarah, Bordas, Rebecca, Pollard, John R., Charlton, Peter A., Golec, Julian M. C., Bertrand, Jay A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
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Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R
Published in Oncotarget (30.07.2014)
Published in Oncotarget (30.07.2014)
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Journal Article
VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
Weber, Peter, Wang, Ping, Maddens, Stephane, Wang, Paul Sh, Wu, Rongqian, Miksa, Michael, Dong, Weifeng, Mortimore, Michael, Golec, Julian M C, Charlton, Peter
Published in Critical care (London, England) (01.01.2009)
Published in Critical care (London, England) (01.01.2009)
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Cerambycid Communities and Their Associated Hymenopteran Parasitoids From Major Hardwood Trees in Delaware: Implications for Biocontrol of Invasive Longhorned Beetles
Golec, Julian R, Aparicio, Ellen, Wang, Xingeng, Duan, Jian J, Fuester, Roger W, Tatman, Daria, Kula, Robert R
Published in Environmental entomology (14.04.2020)
Published in Environmental entomology (14.04.2020)
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Influence of Temperature on the Reproductive and Developmental Biology of Ontsira mellipes (Hymenoptera: Braconidae): Implications for Biological Control of the Asian Longhorned Beetle (Coleoptera: Cerambycidae)
Golec, Julian R, Duan, Jian J, Hough-Goldstein, Judith
Published in Environmental entomology (01.08.2017)
Published in Environmental entomology (01.08.2017)
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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Miller, Karen M, Harrington, Elizabeth A, Bebbington, David, Moore, Jeff, Rasmussen, Richele K, Ajose-Adeogun, Abi O, Nakayama, Tomoko, Graham, Joanne A, Demur, Cecile, Hercend, Thierry, Diu-Hercend, Anita, Su, Michael, Golec, Julian M C
Published in Nature medicine (01.03.2004)
Published in Nature medicine (01.03.2004)
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Life History, Reproductive Biology, and Larval Development of Ontsira mellipes (Hymenoptera: Braconidae), a Newly Associated Parasitoid of the Invasive Asian Longhorned Beetle (Coleoptera: Cerambycidae)
Golec, Julian R, Duan, Jian J, Aparicio, Ellen, Hough-Goldstein, Judith
Published in Journal of economic entomology (01.08.2016)
Published in Journal of economic entomology (01.08.2016)
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Journal Article
Laboratory adaptation of a native North American parasitoid to an exotic wood-boring beetle: implications for biological control of invasive pests
Golec, Julian R., Duan, Jian J., Rim, Kaitlin, Hough-Goldstein, Judith, Aparicio, Ellen A.
Published in Journal of pest science (01.06.2019)
Published in Journal of pest science (01.06.2019)
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Journal Article
The discovery of the potent aurora inhibitor MK-0457 (VX-680)
Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Journal Article
Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1
Folkes, Adrian, Roe, Michael B, Sohal, Sukhjit, Golec, Julian, Faint, Richard, Brooks, Teresa, Charlton, Peter
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
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Journal Article
Novel Inhibitors of Plasminogen Activator Inhibitor-1: Development of New Templates From Diketopiperazines
Wang, Shouming, Golec, Julian, Miller, Warren, Milutinovic, Sandra, Folkes, Adrian, Williams, Susannah, Brooks, Teresa, Hardman, Kevin, Charlton, Peter, Wren, Stephen, Spencer, John
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
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Rational Design of 5‑(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor
Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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