Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, Maccormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R
Published in Nature chemical biology (13.04.2011)
Published in Nature chemical biology (13.04.2011)
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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA
Swan, Michael K., Legris, Valerie, Tanner, Adam, Reaper, Philip M., Vial, Sarah, Bordas, Rebecca, Pollard, John R., Charlton, Peter A., Golec, Julian M. C., Bertrand, Jay A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Miller, Karen M, Harrington, Elizabeth A, Bebbington, David, Moore, Jeff, Rasmussen, Richele K, Ajose-Adeogun, Abi O, Nakayama, Tomoko, Graham, Joanne A, Demur, Cecile, Hercend, Thierry, Diu-Hercend, Anita, Su, Michael, Golec, Julian M C
Published in Nature medicine (01.03.2004)
Published in Nature medicine (01.03.2004)
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VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
Weber, Peter, Wang, Ping, Maddens, Stephane, Wang, Paul Sh, Wu, Rongqian, Miksa, Michael, Dong, Weifeng, Mortimore, Michael, Golec, Julian M C, Charlton, Peter
Published in Critical care (London, England) (01.01.2009)
Published in Critical care (London, England) (01.01.2009)
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Structural Basis and Cellular Consequences of Potent Inhibition of the Aurora Kinases, Wild Type Abl Kinase and a T315I Multi-Drug Resistant Mutant Form of Abl Kinase by MK-0457 (VX-680)
Pollard, John R., Charlton, Peter A., Cheetham, Graham M.T., Falcon, Susanna C., Golec, Julian M.C., Griffiths, Matthew R., Weber, Peter
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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The synthesis of a C 9-C 17, fragment of discodermolide
Evans, Philip L., Golec, Julian M.C., Gillespie, Roger J.
Published in Tetrahedron letters (10.12.1993)
Published in Tetrahedron letters (10.12.1993)
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Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme
Golec, Julian M.C., Mullican, Michael D., Murcko, Mark A., Wilson, Keith P., Kay, David P., Jones, Stuart D., Murdoch, Robert, Bemis, Guy W., Raybuck, Scott A., Luong, Yu-Ping, Livingston, David J.
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
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