Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators
Shaw, Simon J., Goff, Dane A., Boralsky, Luke A., Singh, Rajinder, Sweeny, David J., Park, Gary, Sun, Tian-Qiang, Jenkins, Yonchu, Markovtsov, Vadim, Issakani, Sarkiz D., Payan, Donald G., Hitoshi, Yasumichi
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Structure activity relationships leading to the identification of the indirect activator of AMPK, R419
Shaw, Simon J., Goff, Dane A., Carroll, David C., Singh, Rajinder, Sweeny, David J., Park, Gary, Jenkins, Yonchu, Markovtsov, Vadim, Sun, Tian-Qiang, Issakani, Sarkiz D., Hitoshi, Yasumichi, Payan, Donald G.
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L, Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J, McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J, Xu, Xiang, Issakani, Sarkiz D, Carroll, David C, Goff, Dane A, Shaw, Simon J, Singh, Rajinder, Boros, Laszlo G, Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G, Kinsella, Todd M, Hitoshi, Yasumichi
Published in PloS one (05.12.2013)
Published in PloS one (05.12.2013)
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Journal Article
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus
Shaw, Simon J., Goff, Dane A., Lin, Nan, Singh, Rajinder, Li, Wei, McLaughlin, John, Baltgalvis, Kristen A., Payan, Donald G., Kinsella, Todd M.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Enantioselective Synthesis of cis-3-Fluoropiperidin-4-ol, a Building Block for Medicinal Chemistry
Shaw, Simon J, Goff, Dane A, Boralsky, Luke A, Irving, Mark, Singh, Rajinder
Published in Journal of organic chemistry (06.09.2013)
Published in Journal of organic chemistry (06.09.2013)
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Journal Article
Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo
RING, David B, JOHNSON, Kirk W, WAGMAN, Allan S, HAMMOND, Mary-Ellen Wernette, HARRISON, Stephen D, HENRIKSEN, Erik J, NUSS, John M, GOFF, Dane, KINNICK, Tyson R, MA, Sylvia T, REEDER, John W, SAMUELS, Isa, SLABIAK, Trina
Published in Diabetes (New York, N.Y.) (01.03.2003)
Published in Diabetes (New York, N.Y.) (01.03.2003)
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Journal Article
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
Hector, Alvarez, Montgomery, Elizabeth A., Karikari, Collins, Canto, Marcia I., Dunbar, Kerry B., Wang, Jean S., Feldmann, Georg, Hong, Seung-Mo, Haffner, Michael C., Meeker, Alan K., Holland, Sacha J., Yu, Jiaxin, Heckrodt, Thilo J., Zhang, Jing, Ding, Pingyu, Goff, Dane, Singh, Rajinder, Roa, Juan Carlos, Marimuthu, Arivusudar, Riggins, Gregory J., Eshleman, James R., Nelkin, Barry D., Pandey, Akhilesh, Maitra, Anirban
Published in Cancer biology & therapy (15.11.2010)
Published in Cancer biology & therapy (15.11.2010)
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Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways
Jenkins, Yonchu, Sun, Tian-Qiang, Li, Yingwu, Markovtsov, Vadim, Uy, Gerald, Gross, Lisa, Goff, Dane A, Shaw, Simon J, Boralsky, Luke, Singh, Rajinder, Payan, Donald G, Hitoshi, Yasumichi
Published in BMC research notes (25.09.2014)
Published in BMC research notes (25.09.2014)
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Journal Article
Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication
Huang, Peiyong, Goff, Dane A, Huang, Qi, Martinez, Anthony, Xu, Xiang, Crowder, Scott, Issakani, Sarkiz D, Anderson, Emily, Sheng, Ning, Achacoso, Philip, Yen, Ann, Kinsella, Todd, Darwish, Ihab S, Kolluri, Rao, Hong, Hui, Qu, Kunbin, Stauffer, Emily, Goldstein, Eileen, Singh, Rajinder, Payan, Donald G, Lu, H Henry
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Journal Article
R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines
GURURAJA, Tarikere L, GOFF, Dane, HITOSHI, Yasumichi, COOPER, R. D. G, PAYAN, Donald G, KINOSHITA, Taisei, GOLDSTEIN, Eileen, YUNG, Stephanie, MCLAUGHLIN, John, PALI, Erlina, JIANING HUANG, SINGH, Rajinder, DANIEL-ISSAKANI, Sarkiz
Published in Clinical cancer research (15.06.2006)
Published in Clinical cancer research (15.06.2006)
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Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution
LePaih, Jacques, Goff, Dane A., Singh, Rajinder, Shaw, Simon J.
Published in Tetrahedron letters (02.03.2021)
Published in Tetrahedron letters (02.03.2021)
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Journal Article
Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library
Zuckermann, Ronald N, Martin, Eric J, Spellmeyer, David C, Stauber, Gregory B, Shoemaker, Kevin R, Kerr, Janice M, Figliozzi, Gianine M, Goff, Dane A, Siani, Michael A, Simon, Reyna J, Banville, Steven C, Brown, Edward G, Wang, Liang, Richter, Lutz S, Moos, Walter H
Published in Journal of medicinal chemistry (19.08.1994)
Published in Journal of medicinal chemistry (19.08.1994)
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Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy
Goff, Dane, Zhang, Jing, Heckrodt, Thilo, Yu, Jiaxin, Ding, Pingyu, Singh, Raj, Holland, Sacha, Li, Weiqun, Irving, Mark
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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