High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding
Goetz, Gilles H, Farrell, William, Shalaeva, Marina, Sciabola, Simone, Anderson, Dennis, Yan, Jiangli, Philippe, Laurence, Shapiro, Michael J
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
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Journal Article
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators
Boehm, Markus, Beaumont, Kevin, Jones, Rhys, Kalgutkar, Amit S., Zhang, Liying, Atkinson, Karen, Bai, Guoyun, Brown, Janice A., Eng, Heather, Goetz, Gilles H., Holder, Brian R., Khunte, Bhagyashree, Lazzaro, Sarah, Limberakis, Chris, Ryu, Sangwoo, Shapiro, Michael J., Tylaska, Laurie, Yan, Jiangli, Turner, Rushia, Leung, Siegfried S. F., Ramaseshan, Mahesh, Price, David A., Liras, Spiros, Jacobson, Matthew P., Earp, David J., Lokey, R. Scott, Mathiowetz, Alan M., Menhaji-Klotz, Elnaz
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Determining molecular properties with differential mobility spectrometry and machine learning
Walker, Stephen W C, Anwar, Ahdia, Psutka, Jarrod M, Crouse, Jeff, Liu, Chang, Le Blanc, J C Yves, Montgomery, Justin, Goetz, Gilles H, Janiszewski, John S, Campbell, J Larry, Hopkins, W Scott
Published in Nature communications (30.11.2018)
Published in Nature communications (30.11.2018)
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Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2‑(4-(1-(Quinolin-6-ylmethyl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazin-6-yl)‑1H‑pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer
Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H, Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W, Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
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Journal Article
Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network
Sciabola, Simone, Goetz, Gilles H., Bai, Guoyun, Rogers, Bruce N., Gray, David L., Duplantier, Allen, Fonseca, Kari R., Vanase-Frawley, Michelle A., Kablaoui, Natasha M.
Published in Bioorganic & medicinal chemistry (15.08.2016)
Published in Bioorganic & medicinal chemistry (15.08.2016)
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Journal Article
Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography
Russo, Giacomo, Barbato, Francesco, Grumetto, Lucia, Philippe, Laurence, Lynen, Frederic, Goetz, Gilles H.
Published in International journal of pharmaceutics (05.04.2019)
Published in International journal of pharmaceutics (05.04.2019)
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Journal Article
A Fast Chromatographic Method for Estimating Lipophilicity and Ionization in Nonpolar Membrane-Like Environment
Caron, Giulia, Vallaro, Maura, Ermondi, Giuseppe, Goetz, Gilles H, Abramov, Yuriy A, Philippe, Laurence, Shalaeva, Marina
Published in Molecular pharmaceutics (07.03.2016)
Published in Molecular pharmaceutics (07.03.2016)
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Journal Article
Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool
Shalaeva, Marina, Caron, Giulia, Abramov, Yuriy A, O’Connell, Thomas N, Plummer, Mark S, Yalamanchi, Geeta, Farley, Kathleen A, Goetz, Gilles H, Philippe, Laurence, Shapiro, Michael J
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue
Price, David A., Eng, Heather, Farley, Kathleen A., Goetz, Gilles H., Huang, Yong, Jiao, Zhaodong, Kalgutkar, Amit S., Kablaoui, Natasha M., Khunte, Bhagyashree, Liras, Spiros, Limberakis, Chris, Mathiowetz, Alan M., Ruggeri, Roger B., Quan, Jun-Min, Yang, Zhen
Published in Organic & biomolecular chemistry (28.03.2017)
Published in Organic & biomolecular chemistry (28.03.2017)
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Journal Article
Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity
Zhang, Qingzhou, Jiang, Fan, Zhao, Bingchuan, Lin, Huacan, Tian, Yuan, Xie, Mingsheng, Bai, Guoyun, Gilbert, Adam M, Goetz, Gilles H, Liras, Spiros, Mathiowetz, Alan A, Price, David A, Song, Kun, Tu, Meihua, Wu, Yujie, Wang, Tao, Flanagan, Mark E, Wu, Yun-Dong, Li, Zigang
Published in Scientific reports (09.12.2016)
Published in Scientific reports (09.12.2016)
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Journal Article
Desorption electrospray ionization (DESI) with atmospheric pressure ion mobility spectrometry for drug detection
Roscioli, Kristyn M, Tufariello, Jessica A, Zhang, Xing, Li, Shelly X, Goetz, Gilles H, Cheng, Guilong, Siems, William F, Hill, Herbert H
Published in Analyst (London) (07.04.2014)
Published in Analyst (London) (07.04.2014)
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Journal Article
Chemical and biological integrity in natural products screening
Harrigan, George G, Goetz, Gilles H
Published in Combinatorial chemistry & high throughput screening (01.09.2005)
Published in Combinatorial chemistry & high throughput screening (01.09.2005)
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Journal Article
The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2
Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R., Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Goetz, Gilles H., Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C.
Published in ChemMedChem (01.07.2014)
Published in ChemMedChem (01.07.2014)
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Journal Article
Ugibohlin: A New Dibromo-seco-isophakellin from Axinella carteri
Goetz, Gilles H, Harrigan, George G, Likos, John
Published in Journal of natural products (Washington, D.C.) (01.12.2001)
Published in Journal of natural products (Washington, D.C.) (01.12.2001)
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Journal Article
Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazin-6-yl)-1 H -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer
Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H., Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W., Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
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