Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
Edmondson, Scott D, Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D, Morriello, Gregori, Harper, Bart, Moyes, Christopher R, Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N, Ha, Sookhee, Hurley, Amanda L, Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R, Ormes, James, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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Ruthenium-Catalyzed Carboxylative Cyclization of 1,6-Diynes
Kim, Hahn, Goble, Stephen D, Lee, Chulbom
Published in Journal of the American Chemical Society (07.02.2007)
Published in Journal of the American Chemical Society (07.02.2007)
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Journal Article
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder
Moyes, Christopher R, Berger, Richard, Goble, Stephen D, Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N, Chen, Airu S, Dingley, Karen H, Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N, Hurley, Amanda L, Jochnowitz, Nina, Miller, Randall R, Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E, Edmondson, Scott D
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Journal Article
Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H, Wang, Liping, Zhu, Cheng, Kar, Nam F, Li, Bing, Moyes, Christopher R, Goble, Stephen D, Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N, Hurley, Amanda, Li, Xiaofang, Miller, Randy R, Nagabukuro, Hiroshi, Salituro, Gino M, Smith, Sean, Struthers, Mary, Hale, Jeffrey J, Edmondson, Scott D, Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Discovery and optimization of novel 4-[(aminocarbonyl)amino]- N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists
Pasternak, Alexander, Goble, Stephen D., deJesus, Reynalda K., Hreniuk, Donna L., Chung, Christine C., Tota, Michael R., Mazur, Paul, Feighner, Scott D., Howard, Andrew D., Mills, Sander G., Yang, Lihu
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
Pasternak, Alexander, Goble, Stephen D, Struthers, Mary, Vicario, Pasquale P, Ayala, Julia M, Di Salvo, Jerry, Kilburn, Ruth, Wisniewski, Thomas, DeMartino, Julie A, Mills, Sander G, Yang, Lihu
Published in ACS medicinal chemistry letters (08.04.2010)
Published in ACS medicinal chemistry letters (08.04.2010)
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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists
Kothandaraman, Shankaran, Donnely, Karla L., Butora, Gabor, Jiao, Richard, Pasternak, Alexander, Morriello, Gregori J., Goble, Stephen D., Zhou, Changyou, Mills, Sander G., MacCoss, Malcolm, Vicario, Pasquale P., Ayala, Julia M., DeMartino, Julie A., Struthers, Mary, Cascieri, Margaret A., Yang, Lihu
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Journal Article
Heterocyclic acetamide and benzamide derivatives as potent and selective β3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles
GOBLE, Stephen D, LIPING WANG, HURLEY, Amanda, HRENIUK, Donna, PARMEE, Emma, ROBBINS, Michael, SALITURO, Gino, SANFIZ, Anthony, STRECKFUSS, Eric, WATKINS, Eloisa, WEBER, Ann E, STRUTHERS, Mary, LULU HOWELL, K, EDMONDSON, Scott D, BANSAL, Alka, BERGER, Richard, BROCKUNIER, Linda, DISALVO, Jerry, FEIGHNER, Scott, HARPER, Bart, JIAFANG HE
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article
Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists
Pasternak, Alexander, Goble, Stephen D., Vicario, Pasquale P., Di Salvo, Jerry, Ayala, Julia M., Struthers, Mary, DeMartino, Julie A., Mills, Sander G., Yang, Lihu
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists
Pasternak, Alexander, Goble, Stephen D., Doss, George A., Tsou, Nancy N., Butora, Gabor, Vicario, Pasquale P., Ayala, Julia Marie, Struthers, Mary, DeMartino, Julie A., Mills, Sander G., Yang, Lihu
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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Journal Article
Discovery of Vibegron: A Potent and Selective beta(3) Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
Edmondson, Scott D., Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D., Morriello, Gregori, Harper, Bart, Moyes, Christopher R., Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N., Ha, Sookhee, Hurley, Amanda L., Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R., Ormes, James, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E.
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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Journal Article
HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
MOYES CHRIS R, SHEN DONG MING, KAR NAM FUNG, LI BING, WANG LIPING, EDMONDSON SCOTT D, GOBLE STEPHEN D, HA SOOKHEE NICOLE, KOPKA IHOR E, MORRIELLO GREGORI J, ZHU CHENG, CHANG LEHUA, BERGER RICHARD
Year of Publication 25.10.2012
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Year of Publication 25.10.2012
Patent
HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
MOYES CHRIS R, SHEN DONG MING, KAR NAM FUNG, LI BING, WANG LIPING, EDMONDSON SCOTT D, GOBLE STEPHEN D, HA SOOKHEE NICOLE, KOPKA IHOR E, MORRIELLO GREGORI J, ZHU CHENG, CHANG LEHUA, BERGER RICHARD
Year of Publication 20.09.2012
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Year of Publication 20.09.2012
Patent
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective beta(3) Adrenergic Receptor Agonists for the Treatment of Overactive Bladder
Moyes, Christopher R., Berger, Richard, Goble, Stephen D., Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N., Chen, Airu S., Dingley, Karen H., Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N., Hurley, Amanda L., Jochnowitz, Nina, Miller, Randall R., Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E., Edmondson, Scott D.
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Investigation of piperazine benzamides as human beta(3) adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Journal Article
HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
MOYES CHRIS R, SHEN DONG MING, KAR NAM FUNG, LI BING, WANG LIPING, EDMONDSON SCOTT D, GOBLE STEPHEN D, HA SOOKHEE NICOLE, KOPKA IHOR E, MORRIELLO GREGORI J, ZHU CHENG, CHANG LEHUA, BERGER RICHARD
Year of Publication 02.12.2010
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Year of Publication 02.12.2010
Patent
Discovery of Vibegron: A Potent and Selective β 3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
Edmondson, Scott D., Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D., Morriello, Gregori, Harper, Bart, Moyes, Christopher R., Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N., Ha, Sookhee, Hurley, Amanda L., Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R., Ormes, James, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E.
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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Journal Article
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β 3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder
Moyes, Christopher R., Berger, Richard, Goble, Stephen D., Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N., Chen, Airu S., Dingley, Karen H., Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N., Hurley, Amanda L., Jochnowitz, Nina, Miller, Randall R., Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E., Edmondson, Scott D.
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Heterocyclic acetamide and benzamide derivatives as potent and selective b sub(3)-adrenergic receptor agonists with improved rodent pharmacokinetic profiles
Goble, Stephen D, Wang, Liping, Howell, KLulu, Bansal, Alka, Berger, Richard, Brockunier, Linda, DiSalvo, Jerry, Feighner, Scott, Harper, Bart, He, Jiafang, Hurley, Amanda, Hreniuk, Donna, Parmee, Emma, Robbins, Michael, Salituro, Gino, Sanfiz, Anthony, Streckfuss, Eric, Watkins, Eloisa, Weber, Ann E, Struthers, Mary, Edmondson, Scott D
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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