Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Published in Cell host & microbe (14.06.2012)
Published in Cell host & microbe (14.06.2012)
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek
Published in Nature (London) (08.09.2016)
Published in Nature (London) (08.09.2016)
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A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity
Pitman, Jeffrey L, Wheeler, Matthew C, Lloyd, David J, Walker, John R, Glynne, Richard J, Gekakis, Nicholas
Published in PloS one (16.10.2014)
Published in PloS one (16.10.2014)
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Targeting Plasmodium PI(4)K to eliminate malaria
McNamara, Case W., Lee, Marcus C. S., Lim, Chek Shik, Lim, Siau Hoi, Roland, Jason, Nagle, Advait, Simon, Oliver, Yeung, Bryan K. S., Chatterjee, Arnab K., McCormack, Susan L., Manary, Micah J., Zeeman, Anne-Marie, Dechering, Koen J., Kumar, T. R. Santha, Henrich, Philipp P., Gagaring, Kerstin, Ibanez, Maureen, Kato, Nobutaka, Kuhen, Kelli L., Fischli, Christoph, Rottmann, Matthias, Plouffe, David M., Bursulaya, Badry, Meister, Stephan, Rameh, Lucia, Trappe, Joerg, Haasen, Dorothea, Timmerman, Martijn, Sauerwein, Robert W., Suwanarusk, Rossarin, Russell, Bruce, Renia, Laurent, Nosten, Francois, Tully, David C., Kocken, Clemens H. M., Glynne, Richard J., Bodenreider, Christophe, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A.
Published in Nature (London) (12.12.2013)
Published in Nature (London) (12.12.2013)
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Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission
Kuhen, Kelli L, Chatterjee, Arnab K, Rottmann, Matthias, Gagaring, Kerstin, Borboa, Rachel, Buenviaje, Jennifer, Chen, Zhong, Francek, Carolyn, Wu, Tao, Nagle, Advait, Barnes, S Whitney, Plouffe, David, Lee, Marcus C S, Fidock, David A, Graumans, Wouter, van de Vegte-Bolmer, Marga, van Gemert, Geert J, Wirjanata, Grennady, Sebayang, Boni, Marfurt, Jutta, Russell, Bruce, Suwanarusk, Rossarin, Price, Ric N, Nosten, Francois, Tungtaeng, Anchalee, Gettayacamin, Montip, Sattabongkot, Jetsumon, Taylor, Jennifer, Walker, John R, Tully, David, Patra, Kailash P, Flannery, Erika L, Vinetz, Joseph M, Renia, Laurent, Sauerwein, Robert W, Winzeler, Elizabeth A, Glynne, Richard J, Diagana, Thierry T
Published in Antimicrobial agents and chemotherapy (01.09.2014)
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mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
Chu, Jessie, Hong, Nancy A, Masuda, Claudio A, Jenkins, Brian V, Nelms, Keats A, Goodnow, Christopher C, Glynne, Richard J, Wu, Hua, Masliah, Eliezer, Joazeiro, Claudio A.P, Kay, Steve A
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2009)
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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.
Published in Science (American Association for the Advancement of Science) (09.12.2011)
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D., Teriete, Peter, Hull, Mitchell V., Chang, Max W., Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M., Cheng, Kuoyuan, Nguyen, Tu-Trinh H., Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P., Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M., Chapman, Mackenzie E., Lendy, Emma K., Glynne, Richard J., Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D., Johnson, Jeffrey R., Benner, Christopher, Sun, Ren, Schultz, Peter G., Su, Andrew I., García-Sastre, Adolfo, Chatterjee, Arnab K., Yuen, Kwok-Yung, Chanda, Sumit K.
Published in Nature (London) (01.10.2020)
Published in Nature (London) (01.10.2020)
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Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D., Teriete, Peter, Hull, Mitchell V., Chang, Max W., Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M., Cheng, Kuoyuan, Nguyen, Tu-Trinh H., Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P., Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M., Chapman, Mackenzie E., Lendy, Emma K., Glynne, Richard J., Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D., Johnson, Jeffrey R., Benner, Christopher, Sun, Ren, Schultz, Peter G., Su, Andrew I., García-Sastre, Adolfo, Chatterjee, Arnab K., Yuen, Kwok-Yung, Chanda, Sumit K.
Published in Nature (London) (04.07.2024)
Published in Nature (London) (04.07.2024)
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Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase
Song, Taeksun, Park, Yumi, Shamputa, Isdore Chola, Seo, Sunghwa, Lee, Sun Young, Jeon, Han‐Seung, Choi, Hongjo, Lee, Myungsun, Glynne, Richard J., Barnes, S. Whitney, Walker, John R., Batalov, Serge, Yusim, Karina, Feng, Shihai, Tung, Chang‐Shung, Theiler, James, Via, Laura E., Boshoff, Helena I. M., Murakami, Katsuhiko S., Korber, Bette, Barry, Clifton E., Cho, Sang‐Nae
Published in Molecular microbiology (01.03.2014)
Published in Molecular microbiology (01.03.2014)
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KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro
ZEEMAN, Anne-Marie, VAN AMSTERDAM, Sandra M, SAUERWEIN, Robert, GAGARING, Kerstin, BORBOA, Rachel, ZHONG CHEN, KUHEN, Kelli, GLYNNE, Richard J, CHATTERJEE, Arnab K, NAGLE, Advait, ROLAND, Jason, WINZELER, Elizabeth A, MCNAMARA, Case W, LEROY, Didier, CAMPO, Brice, DIAGANA, Thierry T, YEUNG, Bryan K. S, THOMAS, Alan W, KOCKEN, Clemens H. M, VOORBERG-VAN DER WEL, Annemarie, KLOOSTER, Els J, VAN DEN BERG, Alexander, REMARQUE, Edmond J, PLOUFFE, David M, VAN GEMERT, Geert-Jan, LUTY, Adrian
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
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Gene set enrichment in eQTL data identifies novel annotations and pathway regulators
Wu, Chunlei, Delano, David L, Mitro, Nico, Su, Stephen V, Janes, Jeff, McClurg, Phillip, Batalov, Serge, Welch, Genevieve L, Zhang, Jie, Orth, Anthony P, Walker, John R, Glynne, Richard J, Cooke, Michael P, Takahashi, Joseph S, Shimomura, Kazuhiro, Kohsaka, Akira, Bass, Joseph, Saez, Enrique, Wiltshire, Tim, Su, Andrew I
Published in PLoS genetics (01.05.2008)
Published in PLoS genetics (01.05.2008)
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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
Mak, Puiying A, Rao, Srinivasa P. S, Ping Tan, Mai, Lin, Xiuhua, Chyba, Jason, Tay, Joann, Ng, Seow Hwee, Tan, Bee Huat, Cherian, Joseph, Duraiswamy, Jeyaraj, Bifani, Pablo, Lim, Vivian, Lee, Boon Heng, Ling Ma, Ngai, Beer, David, Thayalan, Pamela, Kuhen, Kelli, Chatterjee, Arnab, Supek, Frantisek, Glynne, Richard, Zheng, Jun, Boshoff, Helena I, Barry, Clifton E, Dick, Thomas, Pethe, Kevin, Camacho, Luis R
Published in ACS chemical biology (20.07.2012)
Published in ACS chemical biology (20.07.2012)
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A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence
Li, Guochun, Vega, Raquel, Nelms, Keats, Gekakis, Nicholas, Goodnow, Christopher, McNamara, Peter, Wu, Hua, Hong, Nancy A, Glynne, Richard
Published in PLoS genetics (01.01.2007)
Published in PLoS genetics (01.01.2007)
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Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis
VILCHEZE, Catherine, AV-GAY, Yossef, WHITNEY BARNES, S, LARSEN, Michelle H, WALKER, John R, GLYNNE, Richard J, JACOBS, William R
Published in Antimicrobial Agents and Chemotherapy (01.09.2011)
Published in Antimicrobial Agents and Chemotherapy (01.09.2011)
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Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis
Jun, Jesse E., Wilson, Lauren E., Vinuesa, Carola G., Lesage, Sylvie, Blery, Mathieu, Miosge, Lisa A., Cook, Matthew C., Kucharska, Edyta M., Hara, Hiromitsu, Penninger, Josef M., Domashenz, Heather, Hong, Nancy A., Glynne, Richard J., Nelms, Keats A., Goodnow, Christopher C.
Published in Immunity (Cambridge, Mass.) (01.06.2003)
Published in Immunity (Cambridge, Mass.) (01.06.2003)
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Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice
Lau, Janet, Zhou, Qiang, Sutton, Susan E, Herman, Ann E, Schmedt, Christian, Glynne, Richard
Published in PloS one (15.01.2014)
Published in PloS one (15.01.2014)
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