Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Blackwood, Erik A, Azizi, Khalid, Thuerauf, Donna J, Paxman, Ryan J, Plate, Lars, Kelly, Jeffery W, Wiseman, R Luke, Glembotski, Christopher C
Published in Nature communications (14.01.2019)
Published in Nature communications (14.01.2019)
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Journal Article
New concepts of endoplasmic reticulum function in the heart: Programmed to conserve
Doroudgar, Shirin, Glembotski, Christopher C
Published in Journal of molecular and cellular cardiology (01.02.2013)
Published in Journal of molecular and cellular cardiology (01.02.2013)
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Journal Article
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb
Blackwood, Erik A, Hofmann, Christoph, Santo Domingo, Michelle, Bilal, Alina S, Sarakki, Anup, Stauffer, Winston, Arrieta, Adrian, Thuerauf, Donna J, Kolkhorst, Fred W, Müller, Oliver J, Jakobi, Tobias, Dieterich, Christoph, Katus, Hugo A, Doroudgar, Shirin, Glembotski, Christopher C
Published in Circulation research (04.01.2019)
Published in Circulation research (04.01.2019)
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Journal Article
Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion
Glembotski, Christopher C., Thuerauf, Donna J., Huang, Chengqun, Vekich, John A., Gottlieb, Roberta A., Doroudgar, Shirin
Published in The Journal of biological chemistry (27.07.2012)
Published in The Journal of biological chemistry (27.07.2012)
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Journal Article
ATF6 as a Nodal Regulator of Proteostasis in the Heart
Glembotski, Christopher C, Arrieta, Adrian, Blackwood, Erik A, Stauffer, Winston T
Published in Frontiers in physiology (08.04.2020)
Published in Frontiers in physiology (08.04.2020)
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Journal Article
Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes
Doroudgar, Shirin, Völkers, Mirko, Thuerauf, Donna J, Khan, Mohsin, Mohsin, Sadia, Respress, Jonathan L, Wang, Wei, Gude, Natalie, Müller, Oliver J, Wehrens, Xander H.T, Sussman, Mark A, Glembotski, Christopher C
Published in Circulation research (28.08.2015)
Published in Circulation research (28.08.2015)
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Journal Article
Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage
Völkers, Mirko, Konstandin, Mathias H, Doroudgar, Shirin, Toko, Haruhiro, Quijada, Pearl, Din, Shabana, Joyo, Anya, Ornelas, Luis, Samse, Kaitleen, Thuerauf, Donna J, Gude, Natalie, Glembotski, Christopher C, Sussman, Mark A
Published in Circulation (New York, N.Y.) (05.11.2013)
Published in Circulation (New York, N.Y.) (05.11.2013)
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Journal Article
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
Stauffer, Winston T, Blackwood, Erik A, Azizi, Khalid, Kaufman, Randal J, Glembotski, Christopher C
Published in International journal of molecular sciences (18.02.2020)
Published in International journal of molecular sciences (18.02.2020)
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Journal Article
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1
Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
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Journal Article
mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes
Hofmann, Christoph, Löwenthal, Zoe, Aghajani, Marjan, Kaufman, Randal J, Katus, Hugo A, Frey, Norbert, Glembotski, Christopher C, Völkers, Mirko, Doroudgar, Shirin
Published in American journal of physiology. Heart and circulatory physiology (01.08.2023)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2023)
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Journal Article
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α
Stauffer, Winston T, Arrieta, Adrian, Blackwood, Erik A, Glembotski, Christopher C
Published in International journal of molecular sciences (08.02.2020)
Published in International journal of molecular sciences (08.02.2020)
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Journal Article
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart
Tadimalla, Archana, Belmont, Peter J, Thuerauf, Donna J, Glassy, Matthew S, Martindale, Joshua J, Gude, Natalie, Sussman, Mark A, Glembotski, Christopher C
Published in Circulation research (21.11.2008)
Published in Circulation research (21.11.2008)
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