Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies
KUMMAR, Shivaani, KINDERS, Robert, MURGO, Anthony J, COLLINS, Jerry, STEINBERG, Seth M, ELIOPOULOS, Helen, GIRANDA, Vincent L, GORDON, Gary, HELMAN, Lee, WILTROUT, Robert, TOMASZEWSKI, Joseph E, DOROSHOW, James H, GUTIERREZ, Martin E, RUBINSTEIN, Larry, PARCHMENT, Ralph E, PHILLIPS, Lawrence R, JIUPING JI, MONKS, Anne, LOW, Jennifer A, CHEN, Alice
Published in Journal of clinical oncology (01.06.2009)
Published in Journal of clinical oncology (01.06.2009)
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Journal Article
Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer
Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors
PALMA, Joann P, WANG, Yi-Chun, ZHU, Gui-Dong, PENNING, Thomas D, GIRANDA, Vincent L, ROSENBERG, Saul H, FROST, David J, DONAWHO, Cherrie K, RODRIGUEZ, Luis E, MONTGOMERY, Debra, ELLIS, Paul A, BUKOFZER, Gail, NIQUETTE, Amanda, XUESONG LIU, YAN SHI, LASKO, Loren
Published in Clinical cancer research (01.12.2009)
Published in Clinical cancer research (01.12.2009)
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Journal Article
Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A
Shi, Yan, Solomon, Larry R., Pereda-Lopez, Ana, Giranda, Vincent L., Luo, Yan, Johnson, Eric F., Shoemaker, Alexander R., Leverson, Joel, Liu, Xuesong
Published in The Journal of biological chemistry (11.11.2011)
Published in The Journal of biological chemistry (11.11.2011)
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Journal Article
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells
Gallia, Gary L, Tyler, Betty M, Hann, Christine L, Siu, I-Mei, Giranda, Vincent L, Vescovi, Angelo L, Brem, Henry, Riggins, Gregory J
Published in Molecular cancer therapeutics (01.02.2009)
Published in Molecular cancer therapeutics (01.02.2009)
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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Miyashiro, Julie, Woods, Keith W., Park, Chang H., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Luo, Yan, Fry, Elizabeth H., Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways
Liu, Xuesong, Han, Edward K, Anderson, Mark, Shi, Yan, Semizarov, Dimitri, Wang, Gang, McGonigal, Thomas, Roberts, Lisa, Lasko, Loren, Palma, Joann, Zhu, Gui-Dong, Penning, Thomas, Rosenberg, Saul, Giranda, Vincent L, Luo, Yan, Leverson, Joel, Johnson, Eric F, Shoemaker, Alexander R
Published in Molecular cancer research (01.10.2009)
Published in Molecular cancer research (01.10.2009)
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Journal Article
Small interfering RNA-mediated polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals
RAN GUAN, TAPANG, Paul, LEVERSON, Joel D, ALBERT, Daniel, GIRANDA, Vincent L, YAN LUO
Published in Cancer research (Chicago, Ill.) (01.04.2005)
Published in Cancer research (Chicago, Ill.) (01.04.2005)
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Journal Article
Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks
Liu, Xuesong, Shi, Yan, Guan, Ran, Donawho, Cherrie, Luo, Yanping, Palma, Joann, Zhu, Gui-Dong, Johnson, Eric F, Rodriguez, Luis E, Ghoreishi-Haack, Nayereh, Jarvis, Ken, Hradil, Vincent P, Colon-Lopez, Milagros, Cox, Bryan F, Klinghofer, Vered, Penning, Thomas, Rosenberg, Saul H, Frost, David, Giranda, Vincent L, Luo, Yan
Published in Molecular cancer research (01.10.2008)
Published in Molecular cancer research (01.10.2008)
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Journal Article
Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression
Liu, Xuesong, Shi, Yan, Woods, Keith W., Hessler, Paul, Kroeger, Paul, Wilsbacher, Julie, Wang, Jieyi, Wang, Jean Y., Li, Chunying, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L., Luo, Yan
Published in Neoplasia (New York, N.Y.) (01.08.2008)
Published in Neoplasia (New York, N.Y.) (01.08.2008)
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Journal Article
The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo
PALMA, Joann P, RODRIGUEZ, Luis E, XUESONG LIU, OLSON, Amanda, SALTARELLI, Mary J, YAN SHI, STAVROPOULOS, Jason A, ZHU, Gui-Dong, PENNING, Thomas D, YAN LUO, GIRANDA, Vincent L, ROSENBERG, Saul H, BONTCHEVA-DIAZ, Velitchka D, FROST, David J, DONAWHO, Cherrie K, BOUSKA, Jennifer J, BUKOFZER, Gail, COLON-LOPEZ, Milagros, RAN GUAN, JARVIS, Kenneth, JOHNSON, Eric F, KLINGHOFER, Vered
Published in Anticancer research (01.09.2008)
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Published in Anticancer research (01.09.2008)
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Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas
Yang, Sherry X., Kummar, Shivaani, Steinberg, Seth M., Murgo, Anthony J., Gutierrez, Martin, Rubinstein, Larry, Nguyen, Dat, Kaur, Gurmeet, Chen, Alice P., Giranda, Vincent L, Tomaszewski, Joseph E., Doroshow, James H., Phase 0 Working Group, The National Cancer Institute
Published in Cancer biology & therapy (01.11.2009)
Published in Cancer biology & therapy (01.11.2009)
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Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers
Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Luo, Yan, Liu, Xuesong, Shi, Yan, Guan, Ran, Magnone, Shayna R., Klinghofer, Vered, Johnson, Eric F., Bouska, Jennifer, Shoemaker, Alexander, Oleksijew, Anatol, Jarvis, Ken, Park, Chang, Jong, Ron De, Oltersdorf, Tilman, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Optimal two-stage designs for exploratory basket trials
Zhou, Heng, Liu, Fang, Wu, Cai, Rubin, Eric H., Giranda, Vincent L., Chen, Cong
Published in Contemporary clinical trials (01.10.2019)
Published in Contemporary clinical trials (01.10.2019)
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Journal Article
Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer
Hussain, Maha, Carducci, Michael A., Slovin, Susan, Cetnar, Jeremy, Qian, Jiang, McKeegan, Evelyn M., Refici-Buhr, Marion, Chyla, Brenda, Shepherd, Stacie P., Giranda, Vincent L., Alumkal, Joshi J.
Published in Investigational new drugs (01.10.2014)
Published in Investigational new drugs (01.10.2014)
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Journal Article
Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
Li, Qun, Woods, Keith W., Thomas, Sheela, Zhu, Gui-Dong, Packard, Garrick, Fisher, John, Li, Tongmei, Gong, Jianchun, Dinges, Jurgen, Song, Xiaohong, Abrams, Jason, Luo, Yan, Johnson, Eric F., Shi, Yan, Liu, Xuesong, Klinghofer, Vered, Des Jong, Ron, Oltersdorf, Tilman, Stoll, Vincent S., Jakob, Clarissa G., Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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