Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application
Scapin, Giovanna, Potter, Clinton S, Carragher, Bridget
Published in Cell chemical biology (15.11.2018)
Published in Cell chemical biology (15.11.2018)
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Journal Article
Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis
Scapin, Giovanna, Dandey, Venkata P, Zhang, Zhening, Prosise, Winifred, Hruza, Alan, Kelly, Theresa, Mayhood, Todd, Strickland, Corey, Potter, Clinton S, Carragher, Bridget
Published in Nature (London) (05.04.2018)
Published in Nature (London) (05.04.2018)
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Journal Article
Routine single particle CryoEM sample and grid characterization by tomography
Noble, Alex J, Dandey, Venkata P, Wei, Hui, Brasch, Julia, Chase, Jillian, Acharya, Priyamvada, Tan, Yong Zi, Zhang, Zhening, Kim, Laura Y, Scapin, Giovanna, Rapp, Micah, Eng, Edward T, Rice, William J, Cheng, Anchi, Negro, Carl J, Shapiro, Lawrence, Kwong, Peter D, Jeruzalmi, David, des Georges, Amedee, Potter, Clinton S, Carragher, Bridget
Published in eLife (29.05.2018)
Published in eLife (29.05.2018)
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Journal Article
Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
Scapin, Giovanna, Yang, Xiaoyu, Prosise, Winifred W, McCoy, Mark, Reichert, Paul, Johnston, Jennifer M, Kashi, Ramesh S, Strickland, Corey
Published in Nature structural & molecular biology (01.12.2015)
Published in Nature structural & molecular biology (01.12.2015)
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Journal Article
Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation
Wang, Bo, Bruhn, Jessica F, Weldeab, Asmerom, Wilson, Timothy S, McGilvray, Philip T, Mashore, Michael, Song, Qiong, Scapin, Giovanna, Lin, Yiqing
Published in Chemical communications (Cambridge, England) (12.04.2022)
Published in Chemical communications (Cambridge, England) (12.04.2022)
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Journal Article
Omarigliptin (MK-3102): A Novel Long-Acting DPP‑4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes
Biftu, Tesfaye, Sinha-Roy, Ranabir, Chen, Ping, Qian, Xiaoxia, Feng, Dennis, Kuethe, Jeffrey T, Scapin, Giovanna, Gao, Ying Duo, Yan, Youwei, Krueger, Davida, Bak, Annette, Eiermann, George, He, Jiafang, Cox, Jason, Hicks, Jacqueline, Lyons, Kathy, He, Huaibing, Salituro, Gino, Tong, Sharon, Patel, Sangita, Doss, George, Petrov, Aleksandr, Wu, Joseph, Xu, Shiyao Sherrie, Sewall, Charles, Zhang, Xiaoping, Zhang, Bei, Thornberry, Nancy A, Weber, Ann E
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy
Tran, Nhi L, Senko, Skerdi, Lucier, Kyle W, Farwell, Ashlyn C, Silva, Sabrina M, Dip, Phat V, Poweleit, Nicole, Scapin, Giovanna, Catalano, Claudio
Published in International journal of molecular sciences (20.04.2024)
Published in International journal of molecular sciences (20.04.2024)
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Journal Article
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
Wu, Margaret, Carballo-Jane, Ester, Zhou, Haihong, Zafian, Peter, Dai, Ge, Liu, Mindy, Lao, Julie, Kelly, Terri, Shao, Dan, Gorski, Judith, Pissarnitski, Dmitri, Kekec, Ahmet, Chen, Ying, Previs, Stephen F, Scapin, Giovanna, Gomez-Llorente, Yacob, Hollingsworth, Scott A, Yan, Lin, Feng, Danqing, Huo, Pei, Walford, Geoffrey, Erion, Mark D, Kelley, David E, Lin, Songnian, Mu, James
Published in Nature communications (17.02.2022)
Published in Nature communications (17.02.2022)
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Author Correction: Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
Wu, Margaret, Carballo-Jane, Ester, Zhou, Haihong, Zafian, Peter, Dai, Ge, Liu, Mindy, Lao, Julie, Kelly, Terri, Shao, Dan, Gorski, Judith, Pissarnitski, Dmitri, Kekec, Ahmet, Chen, Ying, Previs, Stephen F, Scapin, Giovanna, Gomez-Llorente, Yacob, Hollingsworth, Scott A, Yan, Lin, Feng, Danqing, Huo, Pei, Walford, Geoffrey, Erion, Mark D, Kelley, David E, Lin, Songnian, Mu, James
Published in Nature communications (23.01.2024)
Published in Nature communications (23.01.2024)
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Journal Article
Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry-Lessons Learned From Examining Over Fifty Samples
Bruhn, Jessica F, Scapin, Giovanna, Cheng, Anchi, Mercado, Brandon Q, Waterman, David G, Ganesh, Thejusvi, Dallakyan, Sargis, Read, Brandon N, Nieusma, Travis, Lucier, Kyle W, Mayer, Megan L, Chiang, Nicole J, Poweleit, Nicole, McGilvray, Philip T, Wilson, Timothy S, Mashore, Michael, Hennessy, Camille, Thomson, Sean, Wang, Bo, Potter, Clinton S, Carragher, Bridget
Published in Frontiers in molecular biosciences (12.07.2021)
Published in Frontiers in molecular biosciences (12.07.2021)
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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)
Biftu, Tesfaye, Qian, Xiaoxia, Chen, Ping, Feng, Dennis, Scapin, Giovanna, Gao, Ying-Duo, Cox, Jason, Sinha Roy, Ranabir, Eiermann, George, He, Huabing, Lyons, Kathy, Salituro, Gino, Patel, Sangita, Petrov, Alexander, Xu, Feng, Xu, Shiyao Sherrie, Zhang, Bei, Caldwell, Charles, Wu, Joseph K., Weber, Ann E.
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
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Journal Article
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase
Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry
Published in PloS one (10.07.2017)
Published in PloS one (10.07.2017)
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Journal Article
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
Palte, Rachel L, Juan, Veronica, Gomez-Llorente, Yacob, Bailly, Marc Andre, Chakravarthy, Kalyan, Chen, Xun, Cipriano, Daniel, Fayad, Ghassan N, Fayadat-Dilman, Laurence, Gathiaka, Symon, Greb, Heiko, Hall, Brian, Handa, Mas, Hsieh, Mark, Kofman, Esther, Lin, Heping, Miller, J Richard, Nguyen, Nhung, O'Neil, Jennifer, Shaheen, Hussam, Sterner, Eric, Strickland, Corey, Sun, Angie, Taremi, Shane, Scapin, Giovanna
Published in Communications biology (29.07.2021)
Published in Communications biology (29.07.2021)
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Journal Article
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Hao, Qi, Rathinaswamy, Manoj K, Klinge, Kelly L, Bratkowski, Matthew, Mafi, Amirhossein, Baumgartner, Christina K, Hamel, Keith M, Veits, Gesine K, Jain, Rinku, Catalano, Claudio, Fitzgerald, Mark, Hird, Alexander W, Park, Eunice, Vora, Harit U, Henderson, James A, Longenecker, Kenton, Hutchins, Charles W, Qiu, Wei, Scapin, Giovanna, Sun, Qi, Stoll, Vincent S, Sun, Chaohong, Li, Ping, Eaton, Dan, Stokoe, David, Fisher, Stewart L, Nasveschuk, Christopher G, Paddock, Marcia, Kort, Michael E
Published in Communications chemistry (16.08.2024)
Published in Communications chemistry (16.08.2024)
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Journal Article
Author Correction: Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
Palte, Rachel L., Juan, Veronica, Gomez-Llorente, Yacob, Bailly, Marc Andre, Chakravarthy, Kalyan, Chen, Xun, Cipriano, Daniel, Fayad, Ghassan N., Fayadat-Dilman, Laurence, Gathiaka, Symon, Greb, Heiko, Hall, Brian, Handa, Mas, Hsieh, Mark, Kofman, Esther, Lin, Heping, Miller, J. Richard, Nguyen, Nhung, O’Neil, Jennifer, Shaheen, Hussam, Sterner, Eric, Strickland, Corey, Sun, Angie, Taremi, Shane, Scapin, Giovanna
Published in Communications biology (15.11.2021)
Published in Communications biology (15.11.2021)
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Journal Article
Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin
Chen, Ping, Feng, Dennis, Qian, Xiaoxia, Apgar, James, Wilkening, Robert, Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Cox, Jason, Doss, George, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Weber, Ann E., Yan, Youwei, Roy, Ranabir Sinha, Biftu, Tesfaye
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Journal Article
Molecular replacement then and now
Scapin, Giovanna
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2013)
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