Search Results - "GINGRICH, Diane E" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

by Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (25.08.2016)

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Journal Article

Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2

Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2

by Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M
Published in The Journal of immunology (1950) (01.10.2011)

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Journal Article

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

by Stump, Kristine L, Lu, Lily D, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Ben J, Angeles, Thelma S, Albom, Mark S, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M
Published in Arthritis research & therapy (21.04.2011)

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Journal Article

Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

by Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D
Published in Journal of medicinal chemistry (24.05.2012)

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Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

by Savage, Mary J., Gingrich, Diane E.
Published in Drug development research (01.03.2009)

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Journal Article

CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers

CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers

by Cheng, Mangeng, Quail, Matthew R, Gingrich, Diane E, Ott, Gregory R, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Cristofani, Flavio, Machiorlatti, Rodolfo, Abele, Cristina, Ator, Mark A, Dorsey, Bruce D, Inghirami, Giorgio, Ruggeri, Bruce A
Published in Molecular cancer therapeutics (01.03.2012)

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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

by Dugan, Benjamin J, Gingrich, Diane E, Mesaros, Eugen F, Milkiewicz, Karen L, Curry, Matthew A, Zulli, Allison L, Dobrzanski, Pawel, Serdikoff, Cynthia, Jan, Mahfuza, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Aimone, Lisa D, Meyer, Sheryl L, Huang, Zeqi, Wells-Knecht, Kevin J, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (14.06.2012)

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Journal Article

2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

by Ott, Gregory R, Wells, Gregory J, Thieu, Tho V, Quail, Matthew R, Lisko, Joseph G, Mesaros, Eugen F, Gingrich, Diane E, Ghose, Arup K, Wan, Weihua, Lu, Lihui, Cheng, Mangeng, Albom, Mark S, Angeles, Thelma S, Huang, Zeqi, Aimone, Lisa D, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (22.09.2011)

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Journal Article

Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

by Allwein, Shawn P, Roemmele, Renee C, Haley, James J, Mowrey, Dale R, Petrillo, Daniel E, Reif, James J, Gingrich, Diane E, Bakale, Roger P
Published in Organic process research & development (20.01.2012)

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Journal Article

2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

by Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Breslin, Henry J., Gingrich, Diane E., Huang, Zeqi, Lisko, Joseph G., Mason, Jennifer L., Milkiewicz, Karen L., Thieu, Tho V., Underiner, Ted L., Wells, Gregory J., Wells-Knecht, Kevin J., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)

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2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

by Wells-Knecht, Kevin J, Ott, Gregory R, Cheng, Mangeng, Wells, Gregory J, Breslin, Henry J, Gingrich, Diane E, Weinberg, Linda, Mesaros, Eugen F, Huang, Zeqi, Yazdanian, Mehran, Ator, Mark A, Aimone, Lisa D, Zeigler, Kelli, Dorsey, Bruce D
Published in Chemical research in toxicology (21.11.2011)

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Journal Article

A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids

A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids

by Dorow, R. L, Gingrich, Diane E
Published in Journal of organic chemistry (01.08.1995)

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Journal Article

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

by Zificsak, Craig A., Gingrich, Diane E., Breslin, Henry J., Dunn, Derek D., Milkiewicz, Karen L., Theroff, Jay P., Thieu, Tho V., Underiner, Ted L., Weinberg, Linda R., Aimone, Lisa D., Albom, Mark S., Mason, Jennifer L., Saville, Lisa, Husten, Jean, Angeles, Thelma S., Finn, James P., Jan, Mahfuza, O’Kane, Teresa M., Dobrzanski, Pawel, Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)

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Journal Article

A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055

A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055

by Gingrich, Diane E, Reddy, Dandu R, Iqbal, Mohamed A, Singh, Jasbir, Aimone, Lisa D, Angeles, Thelma S, Albom, Mark, Yang, Shi, Ator, Mark A, Meyer, Sheryl L, Robinson, Candy, Ruggeri, Bruce A, Dionne, Craig A, Vaught, Jeffry L, Mallamo, John P, Hudkins, Robert L
Published in Journal of medicinal chemistry (04.12.2003)

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Journal Article

Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

by GINGRICH, Diane E., YANG, Shi X., GESSNER, George W., ANGELES, Thelma S., HUDKINS, Robert L.
Published in Journal of medicinal chemistry (02.06.2005)

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Journal Article

Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a

Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a

by GINGRICH, Diane E, HUDKINS, Robert L
Published in Bioorganic & medicinal chemistry letters (21.10.2002)

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Journal Article

Synthesis, Modeling, and In Vitro Activity of (3‘S)-e pi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Synthesis, Modeling, and In Vitro Activity of (3‘S)-e pi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

by Gingrich, Diane E, Yang, Shi X, Gessner, George W, Angeles, Thelma S, Hudkins, Robert L
Published in Journal of medicinal chemistry (02.06.2005)

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Journal Article

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5A] PYRIDINE DERIVATIVES

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5A] PYRIDINE DERIVATIVES

by GINGRICH DIANE E, DUGAN BENJAMIN J, MESAROS EUGEN F, MILKIEWICZ KAREN L, CURRY MATTHEW A, DORSEY BRUCE D
Year of Publication 08.05.2012

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Patent

NOVEL FUSED PYRROLOCARBAZOLES

NOVEL FUSED PYRROLOCARBAZOLES

by TAO MING, GINGRICH DIANE E, UNDERINER THEODORE L, BECKNELL NADINE C, REDDY DANDU R, ZULLI ALLISON L, DIEBOLD JAMES L, HUDKINS ROBERT L
Year of Publication 21.06.2012

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Patent

Abstract 3574: Identification and preclinical characterization of CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase, in lymphoma and non-small cell lung cancer models

Abstract 3574: Identification and preclinical characterization of CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase, in lymphoma and non-small cell lung cancer models

by Cheng, Mangeng, Quail, Matthew R., Gingrich, Diane E., Ott, Gregory R., Lu, Lihui, Wan, Weihua, Albom, Mark S., Angeles, Thelma S., Aimone, Lisa D., Cristofani, Flavio, Machiorlatti, Rodolfo, Abele, Cristina, Ator, Mark A., Dorsey, Bruce D., Inghirami, Giorgio, Ruggeri, Bruce A.
Published in Cancer research (Chicago, Ill.) (15.04.2011)

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