Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
Gavai, Ashvinikumar V, Quesnelle, Claude, Norris, Derek, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Chen, Ke, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, White, Ronald, Rose, Anne, Wang, Haiqing, Yang, Zheng, Ranasinghe, Asoka, D’Arienzo, Celia, Guarino, Victor, Xiao, Lan, Su, Ching, Everlof, Gerry, Arora, Vinod, Shen, Ding Ren, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Meredith, Jere, Trainor, George, Lombardo, Louis J, Olson, Richard, Baran, Phil S, Hunt, John T, Vite, Gregory D, Fischer, Bruce S, Westhouse, Richard A, Lee, Francis Y
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024
Quesnelle, Claude A., Gill, Patrice, Kim, Soong-Hoon, Chen, Libing, Zhao, Yufen, Fink, Brian E., Saulnier, Mark, Frennesson, David, DeMartino, Michael P., Baran, Phil S., Gavai, Ashvinikumar V.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
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Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase
Qiao, Jennifer X, Williams, David, Gill, Patrice, Li, Ling, Norris, Derek, Tokarski, John S, Wong, Jessica, Qi, Huilin, Hafeji, Yamnah, Downes, Daniel P, Degnen, Bill, Wang, Ying-Kai, Locke, Gregory, Fang, Hua, Yu, Fei, Xu, Songmei, Naglich, Joseph, Zhang, Jun, Nanjappa, Purushothama, Dai, Chao, Chourb, Lisa, Napoline, Jonathan, Tester, Richland, Jorge, Christine, Li, Yi-Xin, Mathur, Arvind, Barbieri, Christopher, Soars, Matthew G, Venkatanarayan, Avinashnarayan, Lees, Emma, Borzilleri, Robert M, Gavai, Ashvinikumar V, Wichroski, Michael, Dhar, T G Murali
Published in Journal of medicinal chemistry (22.10.2024)
Published in Journal of medicinal chemistry (22.10.2024)
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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists
Harikrishnan, Lalgudi S., Gill, Patrice, Kamau, Muthoni G., Qin, Lan-Ying, Ruan, Zheming, O'Malley, Daniel, Huynh, Tram, Stachura, Sylwia, Cavallaro, Cullen L., Lu, Zhonghui, J.-W. Duan, James, Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Murtaza, Anwar, Fink, Brian E.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology
He, Liqi, Zhang, Meng Yao, Cox, Matthew, Zhang, Qian, Donnell, Andrew F., Zhang, Yong, Tarby, Christine, Gill, Patrice, Subbaiah, Murugaiah A. M., Ramar, Thangeswaran, Reddy, Maheswara, Puttapaka, Vijaya, Li, Yi-Xin, Sivaprakasam, Prasanna, Critton, David, Mulligan, Dawn, Xie, Chunshan, Ramakrishnan, Radha, Nagar, Jignesh, Dudhgaonkar, Shailesh, Murtaza, Anwar, Oderinde, Martins S., Schieven, Gary L., Mathur, Arvind, Gavai, Ashvinikumar V., Vite, Gregory, Gangwar, Sanjeev, Poudel, Yam B.
Published in ACS medicinal chemistry letters (08.02.2024)
Published in ACS medicinal chemistry letters (08.02.2024)
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NLRP3 조정제
GAVAI ASHVINIKUMAR, SEITZ STEVEN P, O'MALLEY DANIEL, GILL PATRICE, WATTERSON SCOTT HUNTER, GONG HUA
Year of Publication 24.09.2021
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Year of Publication 24.09.2021
Patent
톨-유사 수용체 7 (TLR7) 효능제로서의 C3-치환된 1H-피라졸로[4,3-d]피리미딘 화합물
CONG QIANG, SUBBAIAH MURUGAIAH ANDAPPAN MURUGAIAH, GANGWAR SANJEEV, GILL PATRICE, POUDEL YAM B, GAVAI ASHVINIKUMAR V, SIVAPRAKASAM PRASANNA, BROEKEMA MATTHIAS, JOHNSON WALTER L, TARBY CHRISTINE M
Year of Publication 30.09.2022
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Year of Publication 30.09.2022
Patent
톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물
CONG QIANG, SUBBAIAH MURUGAIAH ANDAPPAN MURUGAIAH, HE LIQI, GANGWAR SANJEEV, POUDEL YAM B, GILL PATRICE, GAVAI ASHVINIKUMAR V, SIVAPRAKASAM PRASANNA, DONNELL ANDREW F, TARBY CHRISTINE M
Year of Publication 30.09.2022
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Year of Publication 30.09.2022
Patent
Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer
Gavai, Ashvinikumar V., Norris, Derek, Tortolani, David, O'Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Dodd, Dharmpal, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Tokarski, John S., Sheriff, Steven, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, D'Arienzo, Celia, Su, Ching, Everlof, Gerry, Zhang, Lisa, Raghavan, Nirmala, Hunt, John T., Poss, Michael, Vite, Gregory D., Westhouse, Richard A., Wee, Susan
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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암의 치료에 사용하기 위한 NLRP3-조정제로서의 치환된 퀴나졸린
O'MALLEY DANIEL, NORRIS DEREK J, GILL PATRICE, GAVAI ASHVINIKUMAR V, BROEKEMA MATTHIAS, ZHANG YONG, WATTERSON SCOTT HUNTER, GONG HUA, TARBY CHRISTINE M
Year of Publication 23.09.2021
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Year of Publication 23.09.2021
Patent
BMS-871: A novel orally active pan-Notch inhibitor as an anticancer agent
Shan, Weifang, Balog, Aaron, Quesnelle, Claude, Gill, Patrice, Han, Wen-Ching, Norris, Derek, Mandal, Sunilkumar, Thiruvenkadam, Raja, Gona, Kiran Babu, Thiyagarajan, Kamalraj, Kandula, Sathiah, McGlinchey, Kelly, Menard, Krista, Wen, Mei-Li, Rose, Anne, White, Ronald, Guarino, Victor, Shen, Ding Ren, Cvijic, Mary Ellen, Ranasinghe, Asoka, Dai, Jun, Zhang, Yingru, Wu, Dauh-Rurng, Mathur, Arvind, Rampulla, Richard, Trainor, George, Hunt, John T., Vite, Gregory D., Westhouse, Richard, Lee, Francis Y., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
NLRP3 조정제
O'MALLEY DANIEL, ROUSH WILLIAM R, GILL PATRICE, GAVAI ASHVINIKUMAR V, GHOSH SHOMIR, WATTERSON SCOTT HUNTER, WILLIAMS DAVID K, GONG HUA, TARBY CHRISTINE M
Year of Publication 16.03.2020
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Year of Publication 16.03.2020
Patent
Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer
Gavai, Ashvinikumar V., Zhao, Yufen, O'Malley, Daniel, Fink, Brian, Quesnelle, Claude, Norris, Derek, Chen, Libing, Kim, Soong-Hoon, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, Wang, Haiqing, Yang, Zheng, Ruan, Qian, Moore, Robin, Rodrigues, David, Ranasinghe, Asoka, D'Arienzo, Celia, Tye, Ching Kim, Su, Ching, Everlof, Gerry, Yarde, Melissa, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Trainor, George, Fischer, Bruce, Hunt, John, Vite, Gregory, Westhouse, Richard, Lee, Francis
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Novel Tricyclic Inhibitors of IκB Kinase
Kempson, James, Spergel, Steven H, Guo, Junqing, Quesnelle, Claude, Gill, Patrice, Belanger, Dominique, Dyckman, Alaric J, Li, Tianle, Watterson, Scott H, Langevine, Charles M, Das, Jagabandhu, Moquin, Robert V, Furch, Joseph A, Marinier, Anne, Dodier, Marco, Martel, Alain, Nirschl, David, Van Kirk, Katy, Burke, James R, Pattoli, Mark A, Gillooly, Kathleen, McIntyre, Kim W, Chen, Laishun, Yang, Zheng, Marathe, Punit H, Wang-Iverson, David, Dodd, John H, McKinnon, Murray, Barrish, Joel C, Pitts, William J
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis
Dyckman, Alaric J., Langevine, Charles M., Quesnelle, Claude, Kempson, James, Guo, Junqing, Gill, Patrice, Spergel, Steven H., Watterson, Scott H., Li, Tianle, Nirschl, David S., Gillooly, Kathleen M., Pattoli, Mark A., McIntyre, Kim W., Chen, Laishun, McKinnon, Murray, Dodd, John H., Barrish, Joel C., Burke, James R., Pitts, William J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS
LEE FRANCIS Y, O'MALLEY DANIEL, GILL PATRICE, ZHAO YUFEN, GAVAI ASHVINIKUMAR V, QUESNELLE CLAUDE A, DELUCCA GEORGE V, FINK BRIAN E
Year of Publication 27.05.2015
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Year of Publication 27.05.2015
Patent
TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
LEE FRANCIS Y, O'MALLEY DANIEL, SCHMITZ WILLIAM D, TOKARSKI JOHN S, DEBENEDETTO MIKKEL V, GAVAI ASHVINIKUMAR V, QUESNELLE CLAUDE A, HAN WEN CHING, DELUCCA GEORGE V, FANG HAIQUAN, MANDAL SUNIL KUMAR, NORRIS DEREK J, DEGNAN ANDREW P, STARRETT JOHN E. JR, VACCARO WAYNE, GILL PATRICE, HILL MATTHEW D, HUANG HONG
Year of Publication 10.08.2016
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Year of Publication 10.08.2016
Patent
Sordaricin antifungal agents
Quesnelle, Claude A, Gill, Patrice, Dodier, Marco, St. Laurent, Denis, Serrano-Wu, Michael, Marinier, Anne, Martel, Alain, Mazzucco, Charles E, Stickle, Terry M, Barrett, John F, Vyas, Dolatrai M, Balasubramanian, Balu N
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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