Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology
Weddell, Jared, Chiney, Manoj S., Bhatnagar, Sumit, Gibbs, John P., Shebley, Mohamad
Published in Clinical and translational science (01.01.2021)
Published in Clinical and translational science (01.01.2021)
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Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results
Gibbs, John P, Fredrickson, Jill, Barbee, Todd, Correa, Itzela, Smith, Brian, Lin, Shao-Lee, Gibbs, Megan A
Published in Journal of clinical pharmacology (01.10.2012)
Published in Journal of clinical pharmacology (01.10.2012)
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Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration
XINGRONG LIU, SMITH, Bill J, HOSEA, Natilie, JIANHUA LIU, NELSON, Frederick R, SZEWC, Mark A, VAN DEUSEN, Jeffrey, CUIPING CHEN, CALLEGARI, Ernesto, BECKER, Stacey L, XI CHEN, CIANFROGNA, Julie, DORAN, Angela C, DORAN, Shawn D, GIBBS, John P
Published in Drug metabolism and disposition (01.09.2006)
Published in Drug metabolism and disposition (01.09.2006)
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Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Liu, Xingrong, Smith, Bill J, Chen, Cuiping, Callegari, Ernesto, Becker, Stacey L, Chen, Xi, Cianfrogna, Julie, Doran, Angela C, Doran, Shawn D, Gibbs, John P, Hosea, Natilie, Liu, Jianhua, Nelson, Frederick R, Szewc, Mark A, Van Deusen, Jeffery
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
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The Effect of Perchlorate, Thiocyanate, and Nitrate on Thyroid Function in Workers Exposed to Perchlorate Long-Term
Braverman, Lewis E, He, XueMei, Pino, Sam, Cross, Mary, Magnani, Barbarajean, Lamm, Steven H, Kruse, Michael B, Engel, Arnold, Crump, Kenny S, Gibbs, John P
Published in The journal of clinical endocrinology and metabolism (01.02.2005)
Published in The journal of clinical endocrinology and metabolism (01.02.2005)
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Journal Article
Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab
Desai, Nihar R, Giugliano, Robert P, Wasserman, Scott M, Gibbs, John P, Liu, Thomas, Scott, Rob, Sabatine, Marc S
Published in JAMA cardiology (01.05.2017)
Published in JAMA cardiology (01.05.2017)
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Minimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 Metabolism
GIBBS, John P, HYLAND, Ruth, YOUDIM, Kuresh
Published in Drug metabolism and disposition (01.09.2006)
Published in Drug metabolism and disposition (01.09.2006)
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Journal Article
Informing Development of Bispecific Antibodies Using Physiologically Based Pharmacokinetic-Pharmacodynamic Models: Current Capabilities and Future Opportunities
Gibbs, John P, Yuraszeck, Theresa, Biesdorf, Carla, Xu, Yang, Kasichayanula, Sreeneeranj
Published in Journal of clinical pharmacology (01.10.2020)
Published in Journal of clinical pharmacology (01.10.2020)
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Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug–drug interaction predictions using a PBPK approach
Bhatnagar, Sumit, Mukherjee, Dwaipayan, Salem, Ahmed Hamed, Miles, Dale, Menon, Rajeev M., Gibbs, John P.
Published in Cancer chemotherapy and pharmacology (01.04.2021)
Published in Cancer chemotherapy and pharmacology (01.04.2021)
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Journal Article
Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels
Dias, Clapton S., PhD, Shaywitz, Adam J., MD, PhD, Wasserman, Scott M., MD, Smith, Brian P., PhD, Gao, Bing, PhD, Stolman, Dina S., MD, MSPH, Crispino, Caroline P., MS, Smirnakis, Karen V., MD, MPH, PhD, Emery, Maurice G., PhD, Colbert, Alexander, BA, Gibbs, John P., PhD, Retter, Marc W., PhD, Cooke, Blaire P., PharmD, Uy, Stephen T., MS, Matson, Mark, MD, Stein, Evan A., MD, PhD
Published in Journal of the American College of Cardiology (06.11.2012)
Published in Journal of the American College of Cardiology (06.11.2012)
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Journal Article
Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins
DIAS, Clapton S, SHAYWITZ, Adam J, GIBBS, John P, RETTER, Marc W, COOKE, Blaire P, UY, Stephen T, MATSON, Mark, STEIN, Evan A, WASSERMAN, Scott M, SMITH, Brian P, BING GAO, STOLMAN, Dina S, CRISPINO, Caroline P, SMIRNAKIS, Karen V, EMERY, Maurice G, COLBERT, Alexander
Published in Journal of the American College of Cardiology (06.11.2012)
Published in Journal of the American College of Cardiology (06.11.2012)
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Journal Article
Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., Graaf, Piet H., Kierzek, Andrzej M.
Published in Clinical pharmacology and therapeutics (01.03.2021)
Published in Clinical pharmacology and therapeutics (01.03.2021)
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Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis
Chen, Ping, Narayanan, Adimoolam, Wu, Benjamin, Gisleskog, Per Olsson, Gibbs, John P., Chow, Andrew T., Melhem, Murad
Published in Clinical pharmacokinetics (2018)
Published in Clinical pharmacokinetics (2018)
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Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies: Retrospective Analysis of Monkey as a Single Species for First-in-Human Prediction
Dong, Jennifer Q., Salinger, David H., Endres, Christopher J., Gibbs, John P., Hsu, Cheng-Pang, Stouch, Brian J., Hurh, Eunju, Gibbs, Megan
Published in Clinical pharmacokinetics (01.02.2011)
Published in Clinical pharmacokinetics (01.02.2011)
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