Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Hochheiser, Inga V., Pilsl, Michael, Hagelueken, Gregor, Moecking, Jonas, Marleaux, Michael, Brinkschulte, Rebecca, Latz, Eicke, Engel, Christoph, Geyer, Matthias
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly
Marleaux, Michael, Anand, Kanchan, Latz, Eicke, Geyer, Matthias
Published in FEBS letters (01.08.2020)
Published in FEBS letters (01.08.2020)
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NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
Stutz, Andrea, Kolbe, Carl-Christian, Stahl, Rainer, Horvath, Gabor L, Franklin, Bernardo S, van Ray, Olivia, Brinkschulte, Rebecca, Geyer, Matthias, Meissner, Felix, Latz, Eicke
Published in The Journal of experimental medicine (05.06.2017)
Published in The Journal of experimental medicine (05.06.2017)
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Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.
Published in Nature chemical biology (01.11.2020)
Published in Nature chemical biology (01.11.2020)
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Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice
Yu, Chien-Hsiung, Moecking, Jonas, Geyer, Matthias, Masters, Seth L.
Published in Journal of molecular biology (19.01.2018)
Published in Journal of molecular biology (19.01.2018)
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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Koenig, Paul-Albert, Das, Hrishikesh, Liu, Hejun, Kümmerer, Beate M, Gohr, Florian N, Jenster, Lea-Marie, Schiffelers, Lisa D J, Tesfamariam, Yonas M, Uchima, Miki, Wuerth, Jennifer D, Gatterdam, Karl, Ruetalo, Natalia, Christensen, Maria H, Fandrey, Caroline I, Normann, Sabine, Tödtmann, Jan M P, Pritzl, Steffen, Hanke, Leo, Boos, Jannik, Yuan, Meng, Zhu, Xueyong, Schmid-Burgk, Jonathan L, Kato, Hiroki, Schindler, Michael, Wilson, Ian A, Geyer, Matthias, Ludwig, Kerstin U, Hällberg, B Martin, Wu, Nicholas C, Schmidt, Florian I
Published in Science (12.02.2021)
Published in Science (12.02.2021)
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Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
Itzen, Friederike, Greifenberg, Ann Katrin, Bösken, Christian A, Geyer, Matthias
Published in Nucleic acids research (08.07.2014)
Published in Nucleic acids research (08.07.2014)
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CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
Krajewska, Malgorzata, Dries, Ruben, Grassetti, Andrew V., Dust, Sofia, Gao, Yang, Huang, Hao, Sharma, Bandana, Day, Daniel S., Kwiatkowski, Nicholas, Pomaville, Monica, Dodd, Oliver, Chipumuro, Edmond, Zhang, Tinghu, Greenleaf, Arno L., Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., Geyer, Matthias, Gerber, Scott A., George, Rani E.
Published in Nature communications (15.04.2019)
Published in Nature communications (15.04.2019)
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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype
Olson, Calla M, Liang, Yanke, Leggett, Alan, Park, Woojun D, Li, Lianbo, Mills, Caitlin E, Elsarrag, Selma Z, Ficarro, Scott B, Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A, Sorger, Peter K, Westover, Ken D, Lin, Charles Y, Kwiatkowski, Nicholas, Gray, Nathanael S
Published in Cell chemical biology (20.06.2019)
Published in Cell chemical biology (20.06.2019)
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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
Bugai, Andrii, Quaresma, Alexandre J.C., Friedel, Caroline C., Lenasi, Tina, Düster, Robert, Sibley, Christopher R., Fujinaga, Koh, Kukanja, Petra, Hennig, Thomas, Blasius, Melanie, Geyer, Matthias, Ule, Jernej, Dölken, Lars, Barborič, Matjaž
Published in Molecular cell (18.04.2019)
Published in Molecular cell (18.04.2019)
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Structural basis of Cdk7 activation by dual T-loop phosphorylation
Düster, Robert, Anand, Kanchan, Binder, Sophie C., Schmitz, Maximilian, Gatterdam, Karl, Fisher, Robert P., Geyer, Matthias
Published in Nature communications (03.08.2024)
Published in Nature communications (03.08.2024)
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The structure and substrate specificity of human Cdk12/Cyclin K
Bösken, Christian A., Farnung, Lucas, Hintermair, Corinna, Merzel Schachter, Miriam, Vogel-Bachmayr, Karin, Blazek, Dalibor, Anand, Kanchan, Fisher, Robert P., Eick, Dirk, Geyer, Matthias
Published in Nature communications (24.03.2014)
Published in Nature communications (24.03.2014)
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CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer
Johnson, Shawn F., Cruz, Cristina, Greifenberg, Ann Katrin, Dust, Sofia, Stover, Daniel G., Chi, David, Primack, Benjamin, Cao, Shiliang, Bernhardy, Andrea J., Coulson, Rhiannon, Lazaro, Jean-Bernard, Kochupurakkal, Bose, Sun, Heather, Unitt, Christine, Moreau, Lisa A., Sarosiek, Kristopher A., Scaltriti, Maurizio, Juric, Dejan, Baselga, José, Richardson, Andrea L., Rodig, Scott J., D’Andrea, Alan D., Balmaña, Judith, Johnson, Neil, Geyer, Matthias, Serra, Violeta, Lim, Elgene, Shapiro, Geoffrey I.
Published in Cell reports (Cambridge) (22.11.2016)
Published in Cell reports (Cambridge) (22.11.2016)
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