Identification of potent inhibitors of the sortilin-progranulin interaction
Stachel, Shawn J., Ginnetti, Anthony T., Johnson, Scott A., Cramer, Paige, Wang, Yi, Bukhtiyarova, Marina, Krosky, Daniel, Stump, Craig, Hurzy, Danielle M., Schlegel, Kelly-Ann, Cooke, Andrew J., Allen, Samantha, O'Donnell, Gregory, Ziebell, Michael, Parthasarathy, Gopal, Getty, Krista L., Ho, Thu, Ou, Yangsi, Jovanovska, Aneta, Carroll, Steve S., Pausch, Mark, Lumb, Kevin, Mosser, Scott D., Voleti, Bhavya, Klein, Daniel J., Soisson, Stephen M., Zerbinatti, Celina, Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
Kleiner, Victoria A, O Fischmann, Thierry, Howe, John A, Beshore, Douglas C, Eddins, Michael J, Hou, Yan, Mayhood, Todd, Klein, Daniel, Nahas, Debbie D, Lucas, Bob J, Xi, He, Murray, Edward, Ma, Daphne Y, Getty, Krista, Fearns, Rachel
Published in Communications biology (19.06.2023)
Published in Communications biology (19.06.2023)
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Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase
Eldrup, Anne B, Allerson, Charles R, Bennett, C. Frank, Bera, Sanjib, Bhat, Balkrishen, Bhat, Neelima, Bosserman, Michele R, Brooks, Jennifer, Burlein, Christine, Carroll, Steven S, Cook, P. Dan, Getty, Krista L, MacCoss, Malcolm, McMasters, Daniel R, Olsen, David B, Prakash, Thazha P, Prhavc, Marija, Song, Quanlai, Tomassini, Joanne E, Xia, Jie
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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In Vivo Imaging of the Programmed Death Ligand 1 by 18 F PET
González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L
Published in Journal of Nuclear Medicine (01.11.2017)
Published in Journal of Nuclear Medicine (01.11.2017)
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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs
Carroll, Steven S, Tomassini, Joanne E, Bosserman, Michele, Getty, Krista, Stahlhut, Mark W, Eldrup, Anne B, Bhat, Balkrishen, Hall, Dawn, Simcoe, Amy L, LaFemina, Robert, Rutkowski, Carrie A, Wolanski, Bohdan, Yang, Zhucheng, Migliaccio, Giovanni, De Francesco, Raffaele, Kuo, Lawrence C, MacCoss, Malcolm, Olsen, David B
Published in The Journal of biological chemistry (04.04.2003)
Published in The Journal of biological chemistry (04.04.2003)
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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease
Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling
Alvarez, Nadine, Adam, Gregory C, Howe, John A, Sharma, Vijeta, Zimmerman, Matthew D, Dolgov, Enriko, Rasheed, Risha, Nizar, Fatima, Sahay, Khushboo, Nelson, Andrew M, Park, Steven, Zhou, Xiaoyan, Burlein, Christine, Fay, John F, Iwamoto, Daniel V, Bahnck-Teets, Carolyn M, Getty, Krista L, Lin Goh, Shih, Salhab, Imad, Smith, Keith, Boyce, Christopher W, Cabalu, Tamara D, Murgolo, Nicholas, Fox, Nicholas G, Mayhood, Todd W, Shurtleff, Valerie W, Layton, Mark E, Parish, Craig A, McCauley, John A, Olsen, David B, Perlin, David S
Published in Viruses (01.07.2024)
Published in Viruses (01.07.2024)
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Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads
Caulfield, Michael J., Dudkin, Vadim Y., Ottinger, Elizabeth A., Getty, Krista L., Zuck, Paul D., Kaufhold, Robin M., Hepler, Robert W., McGaughey, Georgia B., Citron, Michael, Hrin, Renee C., Wang, Ying-Jie, Miller, Michael D., Joyce, Joseph G.
Published in The Journal of biological chemistry (24.12.2010)
Published in The Journal of biological chemistry (24.12.2010)
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Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro
Migliaccio, Giovanni, Tomassini, Joanne E., Carroll, Steven S., Tomei, Licia, Altamura, Sergio, Bhat, Balkrishen, Bartholomew, Linda, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Cortese, Riccardo, De Francesco, Raffaele, Eldrup, Anne B., Getty, Krista L., Hou, Xiaoli S., LaFemina, Robert L., Ludmerer, Steven W., MacCoss, Malcolm, McMasters, Daniel R., Stahlhut, Mark W., Olsen, David B., Hazuda, Daria J., Flores, Osvaldo A.
Published in The Journal of biological chemistry (05.12.2003)
Published in The Journal of biological chemistry (05.12.2003)
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Journal Article
In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET
González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L
Published in The Journal of nuclear medicine (1978) (01.11.2017)
Published in The Journal of nuclear medicine (1978) (01.11.2017)
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Journal Article
A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties
OLSEN, David B, ELDRUP, Anne B, GROBLER, Jay A, LAFEMINA, Robert L, MARKEL, Eric J, MIGLIACCIO, Giovanni, PRHAVC, Marija, STAHLHUT, Mark W, TOMASSINI, Joanne E, MACCOSS, Malcolm, HAZUDA, Daria J, CARROLL, Steven S, BARTHOLOMEW, Linda, BHAT, Balkrishen, BOSSERMAN, Michele R, CECCACCI, Alessandra, COLWELL, Lawrence F, FAY, John F, FLORES, Osvaldo A, GETTY, Krista L
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
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Journal Article
Inhibitory Effect of 2′-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells
TOMASSINI, Joanne E, GETTY, Krista, MCMASTERS, Daniel R, MIGLIACCIO, Giovanni, OLSEN, David B, STAHLHUT, Mark W, SHIM, Sung, BHAT, Balkrishen, ELDRUP, Anne B, PRAKASH, Thazha P, CARROLL, Steven S, FLORES, Osvaldo, MACCOSS, Malcolm
Published in Antimicrobial Agents and Chemotherapy (01.05.2005)
Published in Antimicrobial Agents and Chemotherapy (01.05.2005)
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Journal Article
In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET
Trotter, Dinko E. Gonzalez, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M., Miller, Patricia J., O'Malley, Stacey S., Lin, Shu-An, Getty, Krista L., Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., Evelhoch, Jeffrey L.
Published in The Journal of nuclear medicine (1978) (01.11.2017)
Published in The Journal of nuclear medicine (1978) (01.11.2017)
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Preclinical evaluation of new PET tracers for in vivo imaging of PD-L1 expression
Rubins, Daniel J, McQuade, Paul, Klimas, Michael, Meng, Xiangjun, Haley, Hyking, Lin, Shu-An, Getty, Krista L, Trotter, Dinko González
Published in The Journal of nuclear medicine (1978) (01.02.2018)
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Published in The Journal of nuclear medicine (1978) (01.02.2018)
Journal Article
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1
Rubins, Daniel J, Meng, Xiangjun, McQuade, Paul, Klimas, Michael, Getty, Krista, Lin, Shu-An, Connolly, Brett M., O’Malley, Stacey S., Haley, Hyking, Purcell, Mona, Gantert, Liza, Holahan, Marie, Lindgren, Joel, Eklund, Pär, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., González Trotter, Dinko E., Evelhoch, Jeffrey L.
Published in Molecular imaging and biology (01.04.2021)
Published in Molecular imaging and biology (01.04.2021)
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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design
Forster, Ashley B., Abeywickrema, Pravien, Bunda, Jaime, Cox, Christopher D., Cabalu, Tamara D., Egbertson, Melissa, Fay, John, Getty, Krista, Hall, Dawn, Kornienko, Maria, Lu, Jun, Parthasarathy, Gopal, Reid, John, Sharma, Sujata, Shipe, William D., Smith, Sean M., Soisson, Stephen, Stachel, Shawn J., Su, Hua-Poo, Wang, Deping, Berger, Richard
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
In Vivo Imaging of the Programmed Death Ligand 1 by ^sup 18^F PET
Trotter, Dinko E González, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O’Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L
Published in The Journal of nuclear medicine (1978) (01.11.2017)
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Published in The Journal of nuclear medicine (1978) (01.11.2017)
Journal Article
Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication
Eldrup, Anne B, Prhavc, Marija, Brooks, Jennifer, Bhat, Balkrishen, Prakash, Thazha P, Song, Quanlai, Bera, Sanjib, Bhat, Neelima, Dande, Prasad, Cook, P. Dan, Bennett, C. Frank, Carroll, Steven S, Ball, Richard G, Bosserman, Michele, Burlein, Christine, Colwell, Lawrence F, Fay, John F, Flores, Osvaldo A, Getty, Krista, LaFemina, Robert L, Leone, Joseph, MacCoss, Malcolm, McMasters, Daniel R, Tomassini, Joanne E, von Langen, Derek, Wolanski, Bohdan, Olsen, David B
Published in Journal of medicinal chemistry (07.10.2004)
Published in Journal of medicinal chemistry (07.10.2004)
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Journal Article
Dissecting the Effects of DNA Polymerase and Ribonuclease H Inhibitor Combinations on HIV-1 Reverse-Transcriptase Activities
Shaw-Reid, Cathryn A, Feuston, Bradley, Munshi, Vandna, Getty, Krista, Krueger, Julie, Hazuda, Daria J, Parniak, Michael A, Miller, Michael D, Lewis, Dale
Published in Biochemistry (Easton) (08.02.2005)
Published in Biochemistry (Easton) (08.02.2005)
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