Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)
Li, Xiaokai, Shao, Hao, Taylor, Isabelle R, Gestwicki, Jason E
Published in Current topics in medicinal chemistry (01.10.2016)
Published in Current topics in medicinal chemistry (01.10.2016)
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Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation
Assimon, Victoria A, Southworth, Daniel R, Gestwicki, Jason E
Published in Biochemistry (Easton) (08.12.2015)
Published in Biochemistry (Easton) (08.12.2015)
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Journal Article
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
Wang, Chao, Fan, Li, Khawaja, Rabia R., Liu, Bangyan, Zhan, Lihong, Kodama, Lay, Chin, Marcus, Li, Yaqiao, Le, David, Zhou, Yungui, Condello, Carlo, Grinberg, Lea T., Seeley, William W., Miller, Bruce L., Mok, Sue-Ann, Gestwicki, Jason E., Cuervo, Ana Maria, Luo, Wenjie, Gan, Li
Published in Nature communications (12.04.2022)
Published in Nature communications (12.04.2022)
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero, Benjamin, Bourdenx, Mathieu, Luengo, Enrique, Diaz, Antonio, Sohn, Peter Dongmin, Chen, Xu, Wang, Chao, Juste, Yves R., Wegmann, Susanne, Patel, Bindi, Young, Zapporah T., Kuo, Szu Yu, Rodriguez-Navarro, Jose Antonio, Shao, Hao, Lopez, Manuela G., Karch, Celeste M., Goate, Alison M., Gestwicki, Jason E., Hyman, Bradley T., Gan, Li, Cuervo, Ana Maria
Published in Nature communications (14.04.2021)
Published in Nature communications (14.04.2021)
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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state
Lee, Kanghyun, Thwin, Aye C., Nadel, Cory M., Tse, Eric, Gates, Stephanie N., Gestwicki, Jason E., Southworth, Daniel R.
Published in Molecular cell (02.09.2021)
Published in Molecular cell (02.09.2021)
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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel
Paatero, Anja O., Kellosalo, Juho, Dunyak, Bryan M., Almaliti, Jehad, Gestwicki, Jason E., Gerwick, William H., Taunton, Jack, Paavilainen, Ville O.
Published in Cell chemical biology (19.05.2016)
Published in Cell chemical biology (19.05.2016)
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Potential therapeutic applications of autophagy
Rubinsztein, David C, Gestwicki, Jason E, Murphy, Leon O, Klionsky, Daniel J
Published in Nature reviews. Drug discovery (01.04.2007)
Published in Nature reviews. Drug discovery (01.04.2007)
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Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP
Scaglione, K. Matthew, Zavodszky, Eszter, Todi, Sokol V., Patury, Srikanth, Xu, Ping, Rodríguez-Lebrón, Edgardo, Fischer, Svetlana, Konen, John, Djarmati, Ana, Peng, Junmin, Gestwicki, Jason E., Paulson, Henry L.
Published in Molecular cell (19.08.2011)
Published in Molecular cell (19.08.2011)
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Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
Freilich, Rebecca, Betegon, Miguel, Tse, Eric, Mok, Sue-Ann, Julien, Olivier, Agard, David A., Southworth, Daniel R., Takeuchi, Koh, Gestwicki, Jason E.
Published in Nature communications (01.11.2018)
Published in Nature communications (01.11.2018)
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Journal Article
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
Sohn, Peter Dongmin, Huang, Cindy Tzu-Ling, Yan, Rui, Fan, Li, Tracy, Tara E., Camargo, Carolina M., Montgomery, Kelly M., Arhar, Taylor, Mok, Sue-Ann, Freilich, Rebecca, Baik, Justin, He, Manni, Gong, Shiaoching, Roberson, Erik D., Karch, Celeste M., Gestwicki, Jason E., Xu, Ke, Kosik, Kenneth S., Gan, Li
Published in Neuron (Cambridge, Mass.) (06.11.2019)
Published in Neuron (Cambridge, Mass.) (06.11.2019)
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Synthetic Multivalent Ligands as Probes of Signal Transduction
Kiessling, Laura L., Gestwicki, Jason E., Strong, Laura E.
Published in Angewandte Chemie (International ed.) (03.04.2006)
Published in Angewandte Chemie (International ed.) (03.04.2006)
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