Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease
Del Balzo, Ughetta, Signore, Pierre E, Walkinshaw, Gail, Seeley, Todd W, Brenner, Mitchell C, Wang, Qingjian, Guo, Guangjie, Arend, Michael P, Flippin, Lee A, Chow, F Aisha, Gervasi, David C, Kjaergaard, Christian H, Langsetmo, Ingrid, Guenzler, Volkmar, Liu, David Y, Klaus, Steve J, Lin, Al, Neff, Thomas B
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
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Journal Article
Biochemical Purification and Pharmacological Inhibition of a Mammalian Prolyl Hydroxylase Acting on Hypoxia-Inducible Factor
Ivan, Mircea, Haberberger, Thomas, Gervasi, David C., Michelson, Kristen S., Günzler, Volkmar, Kondo, Keiichi, Yang, Haifeng, Sorokina, Irina, Conaway, Ronald C., Conaway, Joan W., Kaelin, William G.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2002)
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Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation
Hernandez-Barrantes, Sonia, Toth, Marta, Bernardo, M.Margarida, Yurkova, Maria, Gervasi, David C., Raz, Yuval, Sang, QingXiang Amy, Fridman, Rafael
Published in The Journal of biological chemistry (21.04.2000)
Published in The Journal of biological chemistry (21.04.2000)
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Journal Article
Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2
Olson, Matthew W., Gervasi, David C., Mobashery, Shahriar, Fridman, Rafael
Published in The Journal of biological chemistry (21.11.1997)
Published in The Journal of biological chemistry (21.11.1997)
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Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2
Toth, Marta, Bernardo, M. Margarida, Gervasi, David C., Soloway, Paul D., Wang, Zhiping, Bigg, Heather F., Overall, Christopher M., DeClerck, Yves A., Tschesche, Harald, Cher, Michael L., Brown, Stephen, Mobashery, Shahriar, Fridman, Rafael
Published in The Journal of biological chemistry (29.12.2000)
Published in The Journal of biological chemistry (29.12.2000)
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FC 071ENHANCED DEGRADATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE (HMGCR) MAY CONTRIBUTE TO THE LOWERING OF LDL CHOLESTEROL SEEN WITH ROXADUSTAT IN CHRONIC KIDNEY DISEASE PATIENTS WITH ANEMIA
Chow, Aisha, Roger, Simon, Pollock, Carol, Gervasi, David, Szczech, Lynda, Walkenshaw, Gail
Published in Nephrology, dialysis, transplantation (29.05.2021)
Published in Nephrology, dialysis, transplantation (29.05.2021)
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Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding
Toth, Marta, Hernandez-Barrantes, Sonia, Osenkowski, Pamela, Bernardo, M. Margarida, Gervasi, David C., Shimura, Yoichiro, Meroueh, Oussama, Kotra, Lakshmi P., Gálvez, Beatriz G., Arroyo, Alicia G., Mobashery, Shahriar, Fridman, Rafael
Published in The Journal of biological chemistry (19.07.2002)
Published in The Journal of biological chemistry (19.07.2002)
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X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor
Kleifeld, Oded, Kotra, Lakshmi P., Gervasi, David C., Brown, Stephen, Bernardo, M. Margarida, Fridman, Rafael, Mobashery, Shahriar, Sagi, Irit
Published in The Journal of biological chemistry (18.05.2001)
Published in The Journal of biological chemistry (18.05.2001)
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Journal Article
Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9
Olson, Matthew W., Bernardo, M.Margarida, Pietila, Martin, Gervasi, David C., Toth, Marta, Kotra, Lakshmi P., Massova, Irina, Mobashery, Shahriar, Fridman, Rafael
Published in The Journal of biological chemistry (28.01.2000)
Published in The Journal of biological chemistry (28.01.2000)
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Journal Article
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1
Olson, M W, Bernardo, M M, Pietila, M, Gervasi, D C, Toth, M, Kotra, L P, Massova, I, Mobashery, S, Fridman, R
Published in The Journal of biological chemistry (28.01.2000)
Published in The Journal of biological chemistry (28.01.2000)
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Journal Article
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme
Kleifeld, O, Kotra, L P, Gervasi, D C, Brown, S, Bernardo, M M, Fridman, R, Mobashery, S, Sagi, I
Published in The Journal of biological chemistry (18.05.2001)
Published in The Journal of biological chemistry (18.05.2001)
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Journal Article
NANOMATERIAL HEATING ELEMENT FOR FUSING APPLICATIONS
ZHAO HONG, LAW KOCK YEE, GERVASI DAVID J, ROOF BRYAN J, ZONA MICHAEL F
Year of Publication 03.05.2010
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Year of Publication 03.05.2010
Patent
Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade
F J Bianco, Jr, D C Gervasi, R Tiguert, D J Grignon, J E Pontes, J D Crissman, R Fridman, D P Wood, Jr
Published in Clinical cancer research (01.12.1998)
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Published in Clinical cancer research (01.12.1998)
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