Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Journal Article
Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
Jenkins, Tracy J, Guan, Bing, Dai, Mingshi, Li, Gang, Lightburn, Thomas E, Huang, Shan, Freeze, B. Scott, Burdi, Douglas F, Jacutin-Porte, Swanee, Bennett, Robert, Chen, Weirong, Minor, Charles, Ghosh, Shomir, Blackburn, Christopher, Gigstad, Kenneth M, Jones, Matthew, Kolbeck, Roland, Yin, Wei, Smith, Sean, Cardillo, Daniel, Ocain, Timothy D, Harriman, Geraldine C
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Journal Article
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Journal Article
Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors
Harriman, Geraldine C., Brewer, Matthias, Bennett, Robert, Kuhn, Cyrille, Bazin, Marc, Larosa, Greg, Skerker, Paul, Cochran, Nancy, Gallant, Debra, Baxter, Deborah, Picarella, Dominic, Jaffee, Bruce, Luly, Jay R., Briskin, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.04.2008)
Published in Bioorganic & medicinal chemistry letters (01.04.2008)
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Journal Article
Selective cell adhesion inhibitors: Barbituric acid based alpha 4 beta 7 - MAdCAM inhibitors
Harriman, Geraldine C, Brewer, Matthias, Bennett, Robert, Kuhn, Cyrille, Bazin, Marc, Larosa, Greg, Skerker, Paul, Cochran, Nancy, Gallant, Debra, Baxter, Deborah, Picarella, Dominic, Jaffee, Bruce, Luly, Jay R, Briskin, Michael J
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Journal Article
TYK2 INHIBITOR AND USE OF THE SAME
SILVANA MARCEL LEIT DE MORADEI, THOMAS H MCLEAN, JEREMY ROBERT GREENWOOD, CRAIG E MASSE, SAYAN MONDAL, GERALDINE C HARRIMAN
Year of Publication 01.08.2023
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Year of Publication 01.08.2023
Patent
ACC INHIBITOR COMBINATION THERAPY FOR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
H JAMES HARWOOD, KAPELLER-LIBERMANN ROSANA, GERALDINE C HARRIMAN, WILLIAM F WESTLIN
Year of Publication 16.07.2020
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Year of Publication 16.07.2020
Patent
TYK2 INHIBITOR AND USE THEREOF
JOSHUA JAHMIL KENNEDY-SMITH, MARKUS DAHLGREN, JEREMY ROBERT GREENWOOD, MEE SHELLEY, DONNA L ROMERO, RONALD T WESTER, CRAIG E MASSE, SAYAN MONDAL, GERALDINE C HARRIMAN
Year of Publication 09.09.2021
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Year of Publication 09.09.2021
Patent
ACC INHIBITORS AND USES THEREOF
JEREMY ROBERT GREENWOOD, CRAIG E MASSE, GERALDINE C HARRIMAN, JAMES HARWOOD, SATHESH BHAT
Year of Publication 05.09.2019
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Year of Publication 05.09.2019
Patent
The Chemistry of the Taxane Diterpene: Stereoselective Reductions of Taxanes
Georg, Gunda I, Harriman, Geraldine C. B, Datta, Apurba, Ali, Syed, Cheruvallath, Zacharia, Dutta, Dinah, Vander Velde, David G, Himes, Richard H
Published in Journal of organic chemistry (27.11.1998)
Published in Journal of organic chemistry (27.11.1998)
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Journal Article
SOLID FORMS OF THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
JON P LAWSON, KUNAL ARVIND VARIA, KATY ALEXANDER, HU SIJUN, KYLE SABOURIN, JOHN C AMEDIO JR, WANG XIAOTIN, GERALDINE C HARRIMAN, VIMAL VARGHESE, YANG XIAOWEI, MICHAEL GEIER, HENRY MORRISON, MARK E SCOTT, SELCUK CALIMSIZ
Year of Publication 09.12.2021
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Year of Publication 09.12.2021
Patent
ACC INHIBITORS AND USES THEREOF
JEREMY ROBERT GREENWOOD, CRAIG E MASSE, GERALDINE C HARRIMAN, JAMES HARWOOD, SATHESH BHAT
Year of Publication 05.04.2018
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Year of Publication 05.04.2018
Patent
TYK2 INHIBITOR AND USE THEREOF
JOSHUA JAHMIL KENNEDY-SMITH, MARKUS DAHLGREN, JEREMY ROBERT GREENWOOD, MEE SHELLEY, DONNA L ROMERO, RONALD T WESTER, CRAIG E MASSE, SAYAN MONDAL, GERALDINE C HARRIMAN
Year of Publication 10.10.2019
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Year of Publication 10.10.2019
Patent
ACC INHIBITORS AND USES THEREOF
JEREMY ROBERT GREENWOOD, CRAIG E MASSE, GERALDINE C HARRIMAN, JAMES HARWOOD, SATHESH BHAT
Year of Publication 29.06.2017
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Year of Publication 29.06.2017
Patent
TYK2 INHIBITOR AND APPLICATION THEREOF
JOSHUA JAHMIL KENNEDY-SMITH, MARKUS DAHLGREN, JEREMY ROBERT GREENWOOD, MEE SHELLEY, DONNA L ROMERO, RONALD T WESTER, CRAIG E MASSE, GERALDINE C HARRIMAN
Year of Publication 28.03.2019
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Year of Publication 28.03.2019
Patent
A Facile One-Flask Conversion of Aldehydes and Ketones to N-Sulfonyl Imines
Georg, Gunda I, Harriman, Geraldine C. B, Peterson, Scott A
Published in Journal of organic chemistry (01.11.1995)
Published in Journal of organic chemistry (01.11.1995)
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Journal Article
IRAK INHIBITOR AND USE THEREOF
MATTHEW DAVID WESSEL, SHAUGHNESSY ROBINSON, MEE SHELLEY, JEREMY ROBERT GREENWOOD, ROSANA KAPELLER-LIBERMANN, RONALD T WESTER, DONNA L ROMERO, CRAIG E MASSE, GERALDINE C HARRIMAN
Year of Publication 12.01.2017
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Year of Publication 12.01.2017
Patent
Synthesis of a Photoaffinity Taxol Analog and Its Use in Labeling Tubulin
Dasgupta, Debjani, Park, Haeil, Harriman, Geraldine C. B, Georg, Gunda I, Himes, Richard H
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Journal Article
Adenosine deaminase inhibitors. Synthesis and biological evaluation of 4-amino-1-[2(S)-hydroxy-3(R)-nonyl]-1H-imidazo[4,5-c]pyridine [3-deaza-(+)-EHNA] and certain C1' derivatives
Harriman, Geraldine C. B, Abushanab, Elie, Stoeckler, Johanna D
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Journal Article