Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation
Marceau, François, Bachelard, Hélène, Bouthillier, Johanne, Fortin, Jean-Philippe, Morissette, Guillaume, Bawolak, Marie-Thérèse, Charest-Morin, Xavier, Gera, Lajos
Published in International immunopharmacology (01.05.2020)
Published in International immunopharmacology (01.05.2020)
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Overcoming prostate cancer drug resistance with a novel organosilicon small molecule
Zhao, Rui, Ma, Xiaowei, Bai, Lijuan, Li, Xin, Mamouni, Kenza, Yang, Yang, Liu, HongYan, Danaher, Alira, Cook, Nicholas, Kucuk, Omer, Hodges, Robert S., Gera, Lajos, Wu, Daqing
Published in Neoplasia (New York, N.Y.) (01.12.2021)
Published in Neoplasia (New York, N.Y.) (01.12.2021)
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Journal Article
Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
Ekins, Sean, Kholodovych, Vladyslav, Ai, Ni, Sinz, Michael, Gal, Joseph, Gera, Lajos, Welsh, William J, Bachmann, Kenneth, Mani, Sridhar
Published in Molecular pharmacology (01.09.2008)
Published in Molecular pharmacology (01.09.2008)
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B-9972 (D-Arg-[Hyp3,Igl5,Oic7,Igl8]-bradykinin) Is an Inactivation-Resistant Agonist of the Bradykinin B2 Receptor Derived from the Peptide Antagonist B-9430 (D-Arg-[Hyp3,Igl5,D-Igl7,Oic8]-bradykinin): Pharmacologic Profile and Effective Induction of Receptor Degradation
Bawolak, Marie-Thérèse, Gera, Lajos, Morissette, Guillaume, Stewart, John M, Marceau, François
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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BKM1740, an Acyl-Tyrosine Bisphosphonate Amide Derivative, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells by Inducing Apoptosis
Seo, Seong Il, Gera, Lajos, Zhau, Haiyen E, Qian, Wei Ping, Iqbal, Shareen, Johnson, Nicole A, Zhang, Shumin, Zayzafoon, Majd, Stewart, John, Wang, Ruoxiang, Chung, Leland W K, Wu, Daqing
Published in Clinical cancer research (01.10.2008)
Published in Clinical cancer research (01.10.2008)
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A Nonpeptide Antagonist Reveals a Highly Glycosylated State of the Rabbit Kinin B1 Receptor
Fortin, Jean-Philippe, Dziadulewicz, Edward K, Gera, Lajos, Marceau, François
Published in Molecular pharmacology (01.04.2006)
Published in Molecular pharmacology (01.04.2006)
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Endogenous Aminopeptidase N Decreases the Potency of Peptide Agonists and Antagonists of the Kinin B1 Receptors in the Rabbit Aorta
Fortin, Jean-Philippe, Gera, Lajos, Bouthillier, Johanne, Stewart, John M, Adam, Albert, Marceau, François
Published in The Journal of pharmacology and experimental therapeutics (01.09.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2005)
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Journal Article
Bradykinin Antagonist Dimer, CU201, Inhibits the Growth of Human Lung Cancer Cell Lines by a "Biased Agonist" Mechanism
Chan, Daniel, Gera, Lajos, Stewart, John, Helfrich, Barbara, Verella-Garcia, Marileila, Johnson, Gary, Baron, Anna, Yang, Jie, Puck, Theodore, Bunn, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2002)
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Fluorescent Ligands of the Bradykinin B1 Receptors: Pharmacologic Characterization and Application to the Study of Agonist-Induced Receptor Translocation and Cell Surface Receptor Expression
Bawolak, Marie-Thérèse, Gera, Lajos, Morissette, Guillaume, Bouthillier, Johanne, Stewart, John M, Gobeil, Lise-Andrée, Lodge, Robert, Adam, Albert, Marceau, François
Published in The Journal of pharmacology and experimental therapeutics (01.04.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2009)
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Discovery of a Dual-Function Peptide That Combines Aminopeptidase N Inhibition and Kinin B1 Receptor Antagonism
Gera, Lajos, Fortin, Jean-Philippe, Adam, Albert, Stewart, John M, Marceau, François
Published in The Journal of pharmacology and experimental therapeutics (01.04.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2006)
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Bradykinin Antagonist Dimer, CU201, Inhibits the Growth of Human Lung Cancer Cell Lines in Vitro and in Vivo and Produces Synergistic Growth Inhibition in Combination with Other Antitumor Agents
CHAN, Daniel C, GERA, Lajos, STEWART, John M, HELFRICH, Barbara, ZHAO, Tom Limin, WAN YONG FENG, CHAN, Kenneth K, COVEY, Joseph M, BUNN, Paul A
Published in Clinical cancer research (01.05.2002)
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Published in Clinical cancer research (01.05.2002)
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Preparation and application of the 5-(4-(9-fluorenylmethyloxycarbonyl)aminomethyl-3,5-dimethoxyphenoxy)-valeric acid (PAL) handle for the solid-phase synthesis of C-terminal peptide amides under mild conditions
Albericio, Fernando, Kneib-Cordonier, Nancy, Biancalana, Sara, Gera, Lajos, Masada, R. Irene, Hudson, Derek, Barany, George
Published in Journal of organic chemistry (01.06.1990)
Published in Journal of organic chemistry (01.06.1990)
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De Novo Designed Amphipathic α‑Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii
Mant, Colin T, Jiang, Ziqing, Gera, Lajos, Davis, Tim, Nelson, Kirsten L, Bevers, Shaun, Hodges, Robert S
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
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Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension
Tian, Wen, Jiang, Xinguo, Tamosiuniene, Rasa, Sung, Yon K, Qian, Jin, Dhillon, Gundeep, Gera, Lajos, Farkas, Laszlo, Rabinovitch, Marlene, Zamanian, Roham T, Inayathullah, Mohammed, Fridlib, Marina, Rajadas, Jayakumar, Peters-Golden, Marc, Voelkel, Norbert F, Nicolls, Mark R
Published in Science translational medicine (28.08.2013)
Published in Science translational medicine (28.08.2013)
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Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension
Tamosiuniene, Rasa, Tian, Wen, Dhillon, Gundeep, Wang, Lijuan, Sung, Yon K, Gera, Lajos, Patterson, Andrew J, Agrawal, Rani, Rabinovitch, Marlene, Ambler, Kelly, Long, Carlin S, Voelkel, Norbert F, Nicolls, Mark R
Published in Circulation research (30.09.2011)
Published in Circulation research (30.09.2011)
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Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS
Nunns, Geoffrey R, Vigneshwar, Navin, Kelher, Marguerite R, Stettler, Gregory R, Gera, Lajos, Reisz, Julie A, D'Alessandro, Angelo, Ryon, Joshua, Hansen, Kirk C, Gamboni, Fabia, Moore, Ernest E, Peltz, Erik D, Cohen, Mitchell J, Jones, Kenneth L, Sauaia, Angela, Liang, Xiayuan, Banerjee, Anirban, Ghasabyan, Arsen, Chandler, James G, Rodawig, Sophia, Jones, Carter, Eitel, Andrew, Hom, Patrick, Silliman, Christopher C
Published in Annals of surgery (01.12.2022)
Published in Annals of surgery (01.12.2022)
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Novel small‐molecule LG1836 inhibits the in vivo growth of castration‐resistant prostate cancer
Chen, Yanhua, Li, Xin, Mamouni, Kenza, Yang, Yang, Danaher, Alira, White, Joseph, Liu, HongYan, Kucuk, Omer, Gera, Lajos, Wu, Daqing
Published in The Prostate (01.09.2020)
Published in The Prostate (01.09.2020)
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Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds
Avdieiev, Stanislav, Gera, Lajos, Havrylyuk, Dmytro, Hodges, Robert S., Lesyk, Roman, Ribrag, Vincent, Vassetzky, Yegor, Kavsan, Vadym
Published in Bioorganic & medicinal chemistry (01.08.2014)
Published in Bioorganic & medicinal chemistry (01.08.2014)
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