RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
Xin, Yurong, Kim, Jinrang, Okamoto, Haruka, Ni, Min, Wei, Yi, Adler, Christina, Murphy, Andrew J., Yancopoulos, George D., Lin, Calvin, Gromada, Jesper
Published in Cell metabolism (11.10.2016)
Published in Cell metabolism (11.10.2016)
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Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
Baum, Alina, Fulton, Benjamin O, Wloga, Elzbieta, Copin, Richard, Pascal, Kristen E, Russo, Vincenzo, Giordano, Stephanie, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Atwal, Gurinder S, Murphy, Andrew J, Stahl, Neil, Yancopoulos, George D, Kyratsous, Christos A
Published in Science (21.08.2020)
Published in Science (21.08.2020)
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REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
Baum, Alina, Ajithdoss, Dharani, Copin, Richard, Zhou, Anbo, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Mohammadi, Kusha, Musser, Bret, Atwal, Gurinder S, Oyejide, Adelekan, Goez-Gazi, Yenny, Dutton, John, Clemmons, Elizabeth, Staples, Hilary M, Bartley, Carmen, Klaffke, Benjamin, Alfson, Kendra, Gazi, Michal, Gonzalez, Olga, Dick, Jr, Edward, Carrion, Jr, Ricardo, Pessaint, Laurent, Porto, Maciel, Cook, Anthony, Brown, Renita, Ali, Vaneesha, Greenhouse, Jack, Taylor, Tammy, Andersen, Hanne, Lewis, Mark G, Stahl, Neil, Murphy, Andrew J, Yancopoulos, George D, Kyratsous, Christos A
Published in Science (27.11.2020)
Published in Science (27.11.2020)
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Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
Wenzel, Sally, Prof, Castro, Mario, MD, Corren, Jonathan, MD, Maspero, Jorge, MD, Wang, Lin, PhD, Zhang, Bingzhi, PhD, Pirozzi, Gianluca, MD, Sutherland, E Rand, MD, Evans, Robert R, PharmD, Joish, Vijay N, PhD, Eckert, Laurent, PhD, Graham, Neil M H, MD, Stahl, Neil, PhD, Yancopoulos, George D, MD, Louis-Tisserand, Mariana, MD, Teper, Ariel, MD
Published in The Lancet (British edition) (02.07.2016)
Published in The Lancet (British edition) (02.07.2016)
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Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial
Stratigos, Alexander J, Sekulic, Aleksandar, Peris, Ketty, Bechter, Oliver, Prey, Sorilla, Kaatz, Martin, Lewis, Karl D, Basset-Seguin, Nicole, Chang, Anne Lynn S, Dalle, Stèphane, Orland, Almudena Fernandez, Licitra, Lisa, Robert, Caroline, Ulrich, Claas, Hauschild, Axel, Migden, Michael R, Dummer, Reinhard, Li, Siyu, Yoo, Suk-Young, Mohan, Kosalai, Coates, Ebony, Jankovic, Vladimir, Fiaschi, Nathalie, Okoye, Emmanuel, Bassukas, Ioannis D, Loquai, Carmen, De Giorgi, Vincenzo, Eroglu, Zeynep, Gutzmer, Ralf, Ulrich, Jens, Puig, Susana, Seebach, Frank, Thurston, Gavin, Weinreich, David M, Yancopoulos, George D, Lowy, Israel, Bowler, Timothy, Fury, Matthew G
Published in The lancet oncology (01.06.2021)
Published in The lancet oncology (01.06.2021)
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Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
Rabe, Klaus F, Nair, Parameswaran, Brusselle, Guy, Maspero, Jorge F, Castro, Mario, Sher, Lawrence, Zhu, Hongjie, Hamilton, Jennifer D, Swanson, Brian N, Khan, Asif, Chao, Jingdong, Staudinger, Heribert, Pirozzi, Gianluca, Antoni, Christian, Amin, Nikhil, Ruddy, Marcella, Akinlade, Bolanle, Graham, Neil M.H, Stahl, Neil, Yancopoulos, George D, Teper, Ariel
Published in The New England journal of medicine (28.06.2018)
Published in The New England journal of medicine (28.06.2018)
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Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial
Bachert, Claus, Mannent, Leda, Naclerio, Robert M, Mullol, Joaquim, Ferguson, Berrylin J, Gevaert, Philippe, Hellings, Peter, Jiao, Lixia, Wang, Lin, Evans, Robert R, Pirozzi, Gianluca, Graham, Neil M, Swanson, Brian, Hamilton, Jennifer D, Radin, Allen, Gandhi, Namita A, Stahl, Neil, Yancopoulos, George D, Sutherland, E. Rand
Published in JAMA : the journal of the American Medical Association (02.02.2016)
Published in JAMA : the journal of the American Medical Association (02.02.2016)
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Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial
Sezer, Ahmet, Kilickap, Saadettin, Gümüş, Mahmut, Bondarenko, Igor, Özgüroğlu, Mustafa, Gogishvili, Miranda, Turk, Haci M, Cicin, Irfan, Bentsion, Dmitry, Gladkov, Oleg, Clingan, Philip, Sriuranpong, Virote, Rizvi, Naiyer, Gao, Bo, Li, Siyu, Lee, Sue, McGuire, Kristina, Chen, Chieh-I, Makharadze, Tamta, Paydas, Semra, Nechaeva, Marina, Seebach, Frank, Weinreich, David M, Yancopoulos, George D, Gullo, Giuseppe, Lowy, Israel, Rietschel, Petra
Published in The Lancet (British edition) (13.02.2021)
Published in The Lancet (British edition) (13.02.2021)
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Targeting key proximal drivers of type 2 inflammation in disease
Gandhi, Namita A., Bennett, Brandy L., Graham, Neil M. H., Pirozzi, Gianluca, Stahl, Neil, Yancopoulos, George D.
Published in Nature reviews. Drug discovery (01.01.2016)
Published in Nature reviews. Drug discovery (01.01.2016)
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Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial
Gogishvili, Miranda, Melkadze, Tamar, Makharadze, Tamta, Giorgadze, Davit, Dvorkin, Mikhail, Penkov, Konstantin, Laktionov, Konstantin, Nemsadze, Gia, Nechaeva, Marina, Rozhkova, Irina, Kalinka, Ewa, Gessner, Christian, Moreno-Jaime, Brizio, Passalacqua, Rodolfo, Li, Siyu, McGuire, Kristina, Kaul, Manika, Paccaly, Anne, Quek, Ruben G. W., Gao, Bo, Seebach, Frank, Weinreich, David M., Yancopoulos, George D., Lowy, Israel, Gullo, Giuseppe, Rietschel, Petra
Published in Nature medicine (01.11.2022)
Published in Nature medicine (01.11.2022)
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ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion
Gusarova, Viktoria, Alexa, Corey A., Na, Erqian, Stevis, Panayiotis E., Xin, Yurong, Bonner-Weir, Susan, Cohen, Jonathan C., Hobbs, Helen H., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Published in Cell (23.10.2014)
Published in Cell (23.10.2014)
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Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma
Wechsler, Michael E, Ruddy, Marcella K, Pavord, Ian D, Israel, Elliot, Rabe, Klaus F, Ford, Linda B, Maspero, Jorge F, Abdulai, Raolat M, Hu, Chih-Chi, Martincova, Renata, Jessel, Andreas, Nivens, Michael C, Amin, Nikhil, Weinreich, David M, Yancopoulos, George D, Goulaouic, Helene
Published in The New England journal of medicine (28.10.2021)
Published in The New England journal of medicine (28.10.2021)
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Evinacumab for Homozygous Familial Hypercholesterolemia
Raal, Frederick J, Rosenson, Robert S, Reeskamp, Laurens F, Hovingh, G. Kees, Kastelein, John J.P, Rubba, Paolo, Ali, Shazia, Banerjee, Poulabi, Chan, Kuo-Chen, Gipe, Daniel A, Khilla, Nagwa, Pordy, Robert, Weinreich, David M, Yancopoulos, George D, Zhang, Yi, Gaudet, Daniel
Published in The New England journal of medicine (20.08.2020)
Published in The New England journal of medicine (20.08.2020)
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ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia
Gaudet, Daniel, Gipe, Daniel A, Pordy, Robert, Ahmad, Zahid, Cuchel, Marina, Shah, Prediman K, Chyu, Kuang-Yuh, Sasiela, William J, Chan, Kuo-Chen, Brisson, Diane, Khoury, Etienne, Banerjee, Poulabi, Gusarova, Viktoria, Gromada, Jesper, Stahl, Neil, Yancopoulos, George D, Hovingh, G. Kees
Published in The New England journal of medicine (20.07.2017)
Published in The New England journal of medicine (20.07.2017)
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Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial
Thaçi, Diamant, Prof, Simpson, Eric L, MD, Beck, Lisa A, Prof, Bieber, Thomas, Prof, Blauvelt, Andrew, MD, Papp, Kim, MD, Soong, Weily, MD, Worm, Margitta, Univ-Prof, Szepietowski, Jacek C, Prof, Sofen, Howard, MD, Kawashima, Makoto, Prof, Wu, Richard, PhD, Weinstein, Steven P, MD, Graham, Neil M H, MD, Pirozzi, Gianluca, MD, Teper, Ariel, MD, Sutherland, E Rand, MD, Mastey, Vera, MS, Stahl, Neil, PhD, Yancopoulos, George D, MD, Ardeleanu, Marius, MD
Published in The Lancet (British edition) (02.01.2016)
Published in The Lancet (British edition) (02.01.2016)
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Intravitreal Aflibercept for Diabetic Macular Edema
Korobelnik, Jean-François, MD, Do, Diana V., MD, Schmidt-Erfurth, Ursula, MD, Boyer, David S., MD, Holz, Frank G., MD, Heier, Jeffrey S., MD, Midena, Edoardo, MD, Kaiser, Peter K., MD, Terasaki, Hiroko, MD, Marcus, Dennis M., MD, Nguyen, Quan D., MD, Jaffe, Glenn J., MD, Slakter, Jason S., MD, Simader, Christian, MD, Soo, Yuhwen, PhD, Schmelter, Thomas, PhD, Yancopoulos, George D., MD, PhD, Stahl, Neil, PhD, Vitti, Robert, MD, Berliner, Alyson J., MD, PhD, Zeitz, Oliver, MD, Metzig, Carola, MD, Brown, David M., MD
Published in Ophthalmology (Rochester, Minn.) (01.11.2014)
Published in Ophthalmology (Rochester, Minn.) (01.11.2014)
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Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis
Hamilton, Jennifer D., PhD, Suárez-Fariñas, Mayte, PhD, Dhingra, Nikhil, BS, Cardinale, Irma, MSc, Li, Xuan, PhD, Kostic, Ana, PhD, Ming, Jeffrey E., MD, PhD, Radin, Allen R., MD, Krueger, James G., MD, Graham, Neil, MD, Yancopoulos, George D., MD, PhD, Pirozzi, Gianluca, MD, PhD, Guttman-Yassky, Emma, MD, PhD
Published in Journal of allergy and clinical immunology (01.12.2014)
Published in Journal of allergy and clinical immunology (01.12.2014)
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Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
Papadopoulos, Nicholas, Martin, Joel, Ruan, Qin, Rafique, Ashique, Rosconi, Michael P., Shi, Ergang, Pyles, Erica A., Yancopoulos, George D., Stahl, Neil, Wiegand, Stanley J.
Published in Angiogenesis (London) (01.06.2012)
Published in Angiogenesis (London) (01.06.2012)
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Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation
Le Floc’h, Audrey, Allinne, Jeanne, Nagashima, Kirsten, Scott, George, Birchard, Dylan, Asrat, Seblewongel, Bai, Yu, Lim, Wei Keat, Martin, Joel, Huang, Tammy, Potocky, Terra B., Kim, Jee H., Rafique, Ashique, Papadopoulos, Nicholas J., Stahl, Neil, Yancopoulos, George D., Murphy, Andrew J., Sleeman, Matthew A., Orengo, Jamie M.
Published in Allergy (Copenhagen) (01.05.2020)
Published in Allergy (Copenhagen) (01.05.2020)
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Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration
Heier, Jeffrey S., MD, Brown, David M., MD, Chong, Victor, MD, Korobelnik, Jean-Francois, MD, Kaiser, Peter K., MD, Nguyen, Quan Dong, MD, Kirchhof, Bernd, MD, Ho, Allen, MD, Ogura, Yuichiro, MD, Yancopoulos, George D., MD, PhD, Stahl, Neil, MD, Vitti, Robert, MD, Berliner, Alyson J., MD, PhD, Soo, Yuhwen, PhD, Anderesi, Majid, MD, Groetzbach, Georg, MD, Sommerauer, Bernd, PhD, Sandbrink, Rupert, MD, PhD, Simader, Christian, MD, Schmidt-Erfurth, Ursula, MD
Published in Ophthalmology (Rochester, Minn.) (01.12.2012)
Published in Ophthalmology (Rochester, Minn.) (01.12.2012)
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