Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids
Deleault, Nathan R, Piro, Justin R, Walsh, Daniel J, Wang, Fei, Ma, Jiyan, Geoghegan, James C, Supattapone, Surachai
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2012)
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Prolonged evolution of the human B cell response to SARS-CoV-2 infection
Sakharkar, Mrunal, Rappazzo, C Garrett, Wieland-Alter, Wendy F, Hsieh, Ching-Lin, Wrapp, Daniel, Esterman, Emma S, Kaku, Chengzi I, Wec, Anna Z, Geoghegan, James C, McLellan, Jason S, Connor, Ruth I, Wright, Peter F, Walker, Laura M
Published in Science Immunology (23.02.2021)
Published in Science Immunology (23.02.2021)
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Evolution of antibody immunity following Omicron BA.1 breakthrough infection
Kaku, Chengzi I., Starr, Tyler N., Zhou, Panpan, Dugan, Haley L., Khalifé, Paul, Song, Ge, Champney, Elizabeth R., Mielcarz, Daniel W., Geoghegan, James C., Burton, Dennis R., Andrabi, Raiees, Bloom, Jesse D., Walker, Laura M.
Published in Nature communications (12.05.2023)
Published in Nature communications (12.05.2023)
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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties
Nyborg, Andrew C, Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C, Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O'Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N, Wilson, David M, Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y, Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A, Osbourn, Jane, Coats, Steven, Baca, Manuel
Published in PloS one (21.12.2016)
Published in PloS one (21.12.2016)
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Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering
Geoghegan, James C, Fleming, Ryan, Damschroder, Melissa, Bishop, Steven M, Sathish, Hasige A, Esfandiary, Reza
Published in mAbs (03.07.2016)
Published in mAbs (03.07.2016)
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Antibody-mediated protection against symptomatic COVID-19 can be achieved at low serum neutralizing titers
Schmidt, Pete, Narayan, Kristin, Li, Yong, Kaku, Chengzi I, Brown, Michael E, Champney, Elizabeth, Geoghegan, James C, Vásquez, Maximiliano, Krauland, Eric M, Yockachonis, Thomas, Bai, Shuangyi, Gunn, Bronwyn M, Cammarata, Anthony, Rubino, Christopher M, Ambrose, Paul, Walker, Laura M
Published in Science translational medicine (22.03.2023)
Published in Science translational medicine (22.03.2023)
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Dissociation of infectivity from seeding ability in prions with alternate docking mechanism
Miller, Michael B, Geoghegan, James C, Supattapone, Surachai
Published in PLoS pathogens (01.07.2011)
Published in PLoS pathogens (01.07.2011)
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Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein
Rappazzo, C. Garrett, Hsieh, Ching-Lin, Rush, Scott A., Esterman, Emma S., Delgado, Teresa, Geoghegan, James C., Wec, Anna Z., Sakharkar, Mrunal, Más, Vicente, McLellan, Jason S., Walker, Laura M.
Published in Immunity (Cambridge, Mass.) (13.09.2022)
Published in Immunity (Cambridge, Mass.) (13.09.2022)
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Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
Geoghegan, James C, Diedrich, Gundo, Lu, Xiaojun, Rosenthal, Kim, Sachsenmeier, Kris F, Wu, Herren, Dall'Acqua, William F, Damschroder, Melissa M
Published in mAbs (02.04.2016)
Published in mAbs (02.04.2016)
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RNAi or overexpression: Alternative therapies for Spinocerebellar Ataxia Type 1
Keiser, Megan S, Geoghegan, James C, Boudreau, Ryan L, Lennox, Kim A, Davidson, Beverly L
Published in Neurobiology of disease (01.08.2013)
Published in Neurobiology of disease (01.08.2013)
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Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO)
Khan, Khalid S, Moore, Philip A S, Wilson, Matthew J, Hooper, Richard, Allard, Shubha, Wrench, Ian, Beresford, Lee, Roberts, Tracy E, McLoughlin, Carol, Geoghegan, James, Daniels, Jane P, Catling, Sue, Clark, Vicki A, Ayuk, Paul, Robson, Stephen, Gao-Smith, Fang, Hogg, Matthew, Lanz, Doris, Dodds, Julie
Published in PLoS medicine (19.12.2017)
Published in PLoS medicine (19.12.2017)
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Chaperone proteins as single component reagents to assess antibody nonspecificity
Kelly, Ryan L., Geoghegan, James C., Feldman, Jared, Jain, Tushar, Kauke, Monique, Le, Doris, Zhao, Jessie, Wittrup, K. Dane
Published in mAbs (03.10.2017)
Published in mAbs (03.10.2017)
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A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial
Khan, Khalid S, Moore, Philip, Wilson, Matthew, Hooper, Richard, Allard, Shubha, Wrench, Ian, Roberts, Tracy, McLoughlin, Carol, Beresford, Lee, Geoghegan, James, Daniels, Jane, Catling, Sue, Clark, Vicki A, Ayuk, Paul, Robson, Stephen, Gao-Smith, Fang, Hogg, Matthew, Jackson, Louise, Lanz, Doris, Dodds, Julie
Published in Health technology assessment (Winchester, England) (01.01.2018)
Published in Health technology assessment (Winchester, England) (01.01.2018)
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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
Mittler, Eva, Wec, Anna Z, Tynell, Janne, Guardado-Calvo, Pablo, Wigren-Byström, Julia, Polanco, Laura C, O'Brien, Cecilia M, Slough, Megan M, Abelson, Dafna M, Serris, Alexandra, Sakharkar, Mrunal, Pehau-Arnaudet, Gerard, Bakken, Russell R, Geoghegan, James C, Jangra, Rohit K, Keller, Markus, Zeitlin, Larry, Vapalahti, Olli, Ulrich, Rainer G, Bornholdt, Zachary A, Ahlm, Clas, Rey, Felix A, Dye, John M, Bradfute, Steven B, Strandin, Tomas, Herbert, Andrew S, Forsell, Mattias N E, Walker, Laura M, Chandran, Kartik
Published in Science translational medicine (16.03.2022)
Published in Science translational medicine (16.03.2022)
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Trans-dominant inhibition of prion propagation in vitro is not mediated by an accessory cofactor
Geoghegan, James C, Miller, Michael B, Kwak, Aimee H, Harris, Brent T, Supattapone, Surachai
Published in PLoS pathogens (01.07.2009)
Published in PLoS pathogens (01.07.2009)
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Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody
Mittler, Eva, Serris, Alexandra, Esterman, Emma S, Florez, Catalina, Polanco, Laura C, O'Brien, Cecilia M, Slough, Megan M, Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M, Wec, Anna Z, Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R, Jangra, Rohit K, Dye, John M, Ahlm, Clas, Rappazzo, C Garrett, Ulrich, Rainer G, Zeitlin, Larry, Geoghegan, James C, Bradfute, Steven B, Sidoli, Simone, Forsell, Mattias N E, Strandin, Tomas, Rey, Felix A, Herbert, Andrew S, Walker, Laura M, Chandran, Kartik, Guardado-Calvo, Pablo
Published in Science translational medicine (14.06.2023)
Published in Science translational medicine (14.06.2023)
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Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions
Deleault, Nathan R., Geoghegan, James C., Nishina, Koren, Kascsak, Richard, Williamson, R. Anthony, Supattapone, Surachai
Published in The Journal of biological chemistry (22.07.2005)
Published in The Journal of biological chemistry (22.07.2005)
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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
Rappazzo, C Garrett, Tse, Longping V, Kaku, Chengzi I, Wrapp, Daniel, Sakharkar, Mrunal, Huang, Deli, Deveau, Laura M, Yockachonis, Thomas J, Herbert, Andrew S, Battles, Michael B, O'Brien, Cecilia M, Brown, Michael E, Geoghegan, James C, Belk, Jonathan, Peng, Linghang, Yang, Linlin, Hou, Yixuan, Scobey, Trevor D, Burton, Dennis R, Nemazee, David, Dye, John M, Voss, James E, Gunn, Bronwyn M, McLellan, Jason S, Baric, Ralph S, Gralinski, Lisa E, Walker, Laura M
Published in Science (19.02.2021)
Published in Science (19.02.2021)
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