Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
LEMM, Julie A, MENGPING LIU, KNIPE, Jay O, COLONNO, Richard, MEANWELL, Nicholas A, KADOW, John F, SANTONE, Kenneth S, ROBERTS, Susan B, MIN GAO, GENTLES, Robert G, MIN DING, VOSS, Stacey, PELOSI, Lenore A, WANG, Ying-Kai, RIGAT, Karen L, MOSURE, Kathleen W, BENDER, John A
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Get full text
Journal Article
Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
Rigat, Karen L., Lu, Hao, Wang, Ying-Kai, Argyrou, Argyrides, Fanslau, Caroline, Beno, Brett, Wang, Yi, Marcinkeviciene, Jovita, Ding, Min, Gentles, Robert G., Gao, Min, Abell, Lynn M., Roberts, Susan B.
Published in The Journal of biological chemistry (28.11.2014)
Published in The Journal of biological chemistry (28.11.2014)
Get full text
Journal Article
Ligand-induced changes in hepatitis C virus NS5B polymerase structure
Rigat, Karen, Wang, Yi, Hudyma, Thomas W., Ding, Min, Zheng, Xiaofan, Gentles, Robert G., Beno, Brett R., Gao, Min, Roberts, Susan B.
Published in Antiviral research (01.11.2010)
Published in Antiviral research (01.11.2010)
Get full text
Journal Article
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Get full text
Journal Article
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Get full text
Journal Article
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity
Lewis, Martin A, Hunihan, Lisa, Watson, John, Gentles, Robert G, Hu, Shuanghua, Huang, Yazhong, Bronson, Joanne, Macor, John E, Beno, Brett R, Ferrante, Meredith, Hendricson, Adam, Knox, Ronald J, Molski, Thaddeus F, Kong, Yan, Cvijic, Mary Ellen, Rockwell, Kristin L, Weed, Michael R, Cacace, Angela M, Westphal, Ryan S, Alt, Andrew, Brown, Jeffrey M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
Get full text
Journal Article
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter ‐1 (SLC7A10)
Brown, Jeffrey M., Hunihan, Lisa, Prack, Margaret M., Harden, David G., Bronson, Joanne, Dzierba, Carolyn D., Gentles, Robert G., Hendricson, Adam, Krause, Rudy, Macor, John E., Westphal, Ryan S.
Published in Journal of neurochemistry (01.04.2014)
Published in Journal of neurochemistry (01.04.2014)
Get full text
Journal Article
Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase
Chupak, Louis S., Zheng, Xiaofan, Hu, Shuanghua, Huang, Yazhong, Ding, Min, Lewis, Martin A., Westphal, Ryan S., Blat, Yuval, McClure, Andrea, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry (01.04.2016)
Published in Bioorganic & medicinal chemistry (01.04.2016)
Get full text
Journal Article
The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase
Ding, Min, He, Feng, Poss, Michael A., Rigat, Karen L., Wang, Ying-Kai, Roberts, Susan B., Qiu, Dike, Fridell, Robert A., Gao, Min, Gentles, Robert G.
Published in Organic & biomolecular chemistry (07.10.2011)
Published in Organic & biomolecular chemistry (07.10.2011)
Get full text
Journal Article
Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity
Appiah, Kingsley K, Blat, Yuval, Robertson, Barbara J, Pearce, Bradley C, Pedicord, Donna L, Gentles, Robert G, Yu, Xuan-Chuan, Mseeh, Faika, Nguyen, Nghi, Swaffield, Jonathan C, Harden, David G, Westphal, Ryan S, Banks, Martyn N, O'Connell, Jonathan C
Published in Journal of biomolecular screening (01.04.2014)
Published in Journal of biomolecular screening (01.04.2014)
Get full text
Journal Article
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels
Gentles, Robert G., Grant-Young, Katherine, Hu, Shuanghua, Huang, Yazhong, Poss, Michael A., Andres, Charles, Fiedler, Tracey, Knox, Ronald, Lodge, Nicholas, Weaver, C. David, Harden, David G.
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
Get full text
Journal Article
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase
Gentles, Robert G., Sheriff, Steven, Beno, Brett R., Wan, Changhong, Kish, Kevin, Ding, Min, Zheng, Xiaofan, Chupak, Louis, Poss, Michael A., Witmer, Mark R., Morin, Paul, Wang, Ying-Kai, Rigat, Karen, Lemm, Julie, Voss, Stacey, Liu, Mengping, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Get full text
Journal Article
SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Gentles, Robert G., Ding, Min, Zheng, Xiaofan, Chupak, Louis, Poss, Michael A., Beno, Brett R., Pelosi, Lenore, Liu, Mengping, Lemm, Julie, Wang, Ying-Kai, Roberts, Susan, Gao, Min, Kadow, John
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Get full text
Journal Article
T 세포 활성화제로서 유용한 치환된 퀴놀리노닐 피페라진 화합물
DING MIN, WARRIER JAYAKUMAR SANKARA, CHUPAK LOUIS S, ZHENG XIAOFAN, OLSON RICHARD E, GENTLES ROBERT G, VELAPARTHI UPENDER
Year of Publication 29.08.2022
Get full text
Year of Publication 29.08.2022
Patent
T 세포 활성화제로서 유용한 치환된 비시클릭 피페리딘 유도체
DING MIN, WARRIER JAYAKUMAR SANKARA, MARTIN SCOTT W, GRUNENFELDER DENISE, CHUPAK LOUIS, ROY SAUMYA, JALAGAM PRASADA RAO, GENTLES ROBERT G, OLSON RICHARD E, VELAPARTHI UPENDER
Year of Publication 29.08.2022
Get full text
Year of Publication 29.08.2022
Patent
Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine KCa channel blockers
GENTLES, Robert G, SHUANGHUA HU, HARDEN, David G, YAZHONG HUANG, GRANT-YOUNG, Katherine, POSS, Michael A, ANDRES, Charles, FIEDLER, Tracey, KNOX, Ronald, LODGE, Nicholas, WEAVER, C. David
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Get full text
Journal Article
T 세포 활성화제로서 유용한 나프티리디논 화합물
DING MIN, CHUPAK LOUIS S, MARTIN SCOTT W, MERCER STEPHEN E, MCDONALD IVAR M, ZHENG XIAOFAN, GENTLES ROBERT G, OLSON RICHARD E, HUANG YAZHONG, VELAPARTHI UPENDER, WICHROSKI MICHAEL
Year of Publication 05.03.2021
Get full text
Year of Publication 05.03.2021
Patent
DGK 억제제 및 체크포인트 길항제의 조합물
DING MIN, TOKARSKI JOHN S, ROY SAUMYA, KAMBLE MANJUNATHA NARAYANA RAO, VELAPARTHI UPENDER, GRUNENFELDER DENISE, ZHENG XIAOFAN, RAJA THIRUVENKADAM, JALAGAM PRASADA RAO, BENCI JOSEPH L, OLSON RICHARD E, CHUPAK LOUIS S, REDDY KOTHA RATHNAKAR, WEE SUSAN, DARNE CHETAN P, WANG XINYU, TONUKUNURU GOPIKISHAN, WARRIER JAYAKUMAR SANKARA, MARTIN SCOTT W, WICHROSKI MICHAEL J, MCDONALD IVAR M, DASGUPTA BIRESHWAR, MANNOORI RAJU, RAHAMAN HASIBUR, VELAIAH SIVASUDAR, GENTLES ROBERT G, HUANG YAZHONG
Year of Publication 25.08.2022
Get full text
Year of Publication 25.08.2022
Patent
T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물
DING MIN, CHUPAK LOUIS S, TOKARSKI JOHN S, REDDY KOTHA RATHNAKAR, ROY SAUMYA, TONUKUNURU GOPIKISHAN, KAMBLE MANJUNATHA NARAYANA RAO, VELAPARTHI UPENDER, WARRIER JAYAKUMAR SANKARA, DARNE CHETAN PADMAKAR, MARTIN SCOTT W, MCDONALD IVAR M, ZHENG XIAOFAN, DASGUPTA BIRESHWAR, MANNOORI RAJU, RAJA THIRUVENKADAM, JALAGAM PRASADA RAO, RAHAMAN HASIBUR, VELAIAH SIVASUDAR, GENTLES ROBERT G, OLSON RICHARD E, HUANG YAZHONG
Year of Publication 05.03.2021
Get full text
Year of Publication 05.03.2021
Patent