Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease
Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks
Seierstad, Mark, Tichenor, Mark S, DesJarlais, Renee L, Na, Jim, Bacani, Genesis M, Chung, De Michael, Mercado-Marin, Eduardo V, Steffens, Helena C, Mirzadegan, Taraneh
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain
Chrovian, Christa C, Soyode-Johnson, Akinola, Ao, Hong, Bacani, Genesis M, Carruthers, Nicholas I, Lord, Brian, Nguyen, Leslie, Rech, Jason C, Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A
Published in ACS chemical neuroscience (20.04.2016)
Published in ACS chemical neuroscience (20.04.2016)
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Journal Article
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillán, Alejandro, Wiener, John J.M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
CHEN WEI, BRAHMANANDA GHOSH, CHARLOTTE POOLEY DECKHUT, XIAO KUN, JAMES P EDWARDS, SCOTT D BEMBENEK, ZHANG FEIHUANG, NIDHI ARORA, JOSEPH KENT BARBAY, WEI JIANMEI, JENNIFER D VENABLE, CAI MIN, KEVIN D KREUTTER, ZHU YAOPING, WU YAO, GENESIS M BACANI, JOHN J M WIENER, LI GANG, MARK S TICHENOR
Year of Publication 13.05.2021
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Year of Publication 13.05.2021
Patent
Azabenzthiazole inhibitors of leukotriene A(4) hydrolase
Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillan, Alejandro, Wiener, John J. M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Inhibitors of Bruton's tyrosine kinase and method of their use
Bembenek, Scott D, Kreutter, Kevin D, Wiener, John J. M, Bacani, Genesis M, Arora, Nidhi, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
Patent
SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
RAYMOND, Donald, WEI, Jianmei, CHAI, Wenying, CHUNG, De Michael, SUNDBERG, Thomas, BACANI, Genesis M, HIRST, Gavin, SEIERSTAD, Mark, VENABLE, Jennifer D, XAVIER, Ramnik, TICHENOR, Mark S, GOLDBERG, Steven D, SMITH, Russel C, KAUSHIK, Virendar, MERCADO-MARIN, Eduardo V
Year of Publication 30.05.2024
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Year of Publication 30.05.2024
Patent
SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
RAYMOND, Donald, WEI, Jianmei, CHAI, Wenying, CHUNG, De Michael, SUNDBERG, Thomas, BACANI, Genesis M, HIRST, Gavin, SEIERSTAD, Mark, VENABLE, Jennifer D, KAUSHIK, Virnedar, XAVIER, Ramnik, STEFFENS, Helena C, TICHENOR, Mark S, GOLDBERG, Steven D, SMITH, Russel C, MERCADO-MARIN, Eduardo V
Year of Publication 16.05.2024
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Year of Publication 16.05.2024
Patent
SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
RAYMOND, Donald, WEI, Jianmei, CHAI, Wenying, SUNDBERG, Thomas, CHUNG, De, Michael, VENABLE, Jennifer, D, HIRST, Gavin, SEIERSTAD, Mark, SMITH, Russel, C, MERCADO-MARIN, Eduardo, V, XAVIER, Ramnik, GOLDBERG, Steven, D, BACANI, Genesis, M, KAUSHIK, Virendar, TICHENOR, Mark, S
Year of Publication 06.12.2023
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Year of Publication 06.12.2023
Patent
SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
RAYMOND, Donald, WEI, Jianmei, CHAI, Wenying, CHUNG, De Michael, SUNDBERG, Thomas, VENABLE, Jennifer, D, HIRST, Gavin, SEIERSTAD, Mark, SMITH, Russel, C, MERCADO-MARIN, Eduardo, V, XAVIER, Ramnik, GOLDBERG, Steven, D, BACANI, Genesis, M, KAUSHIK, Virendar, STEFFENS, Helena, C, TICHENOR, Mark, S
Year of Publication 06.12.2023
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Year of Publication 06.12.2023
Patent
Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
Koudriakova, Tatiana, Krawczuk, Paul J, Seierstad, Mark, Kreutter, Kevin D, Rizzolio, Michele C, Bacani, Genesis M, Chai, Wenying, Tichenor, Mark S, Smith, Russell C, Wang, Aihua, Leonard, Kristi, Venable, Jennifer D
Year of Publication 28.11.2023
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Year of Publication 28.11.2023
Patent
SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES
KRAWCZUK, Paul J, CHAI, Wenying, VENABLE, Jennifer D, WANG, Aihua, TICHENOR, Mark S, BACANI, Genesis M, RIZZOLIO, Michele C, KOUDRIAKOVA, Tatiana, SEIERSTAD, Mark, SMITH, Russell C, KREUTTER, Kevin D, LEONARD, Kristi
Year of Publication 03.05.2023
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Year of Publication 03.05.2023
Patent
Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
Koudriakova, Tatiana, Krawczuk, Paul J, Seierstad, Mark, Kreutter, Kevin D, Rizzolio, Michele C, Bacani, Genesis M, Chai, Wenying, Tichenor, Mark S, Smith, Russel C, Wang, Aihua, Leonard, Kristi, Venable, Jennifer D
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
Patent
INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
Bembenek, Scott D, ARORA, Nidhi, Kreutter, Kevin D, Bacani, Genesis M, Wiener, John J.M, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
Patent
INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
VENABLE, JENNIFER D, WU, YAO, ZHANG, FEIHUANG, CAI, MIN, BEMBENEK, SCOTT D, XIAO, KUN, ZHU, YAOPING, EDWARDS, JAMES P, BACANI, GENESIS M, DECKHUT, CHARLOTTE POOLEY, WEI, JIANMEI, LI, GANG, TICHENOR, MARK S, WIENER, JOHN J. M, HAO, BAOYU, ZHANG, ZHENG, GHOSH, BRAHMANANDA, ARORA, NIDHI, KREUTTER, KEVIN D, CHEN, WEI, BARBAY, JOSEPH KENT
Year of Publication 16.01.2024
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Year of Publication 16.01.2024
Patent
POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
VENABLE, JENNIFER D, WU, YAO, ZHANG, FEIHUANG, CAI, MIN, BEMBENEK, SCOTT D, XIAO, KUN, ZHU, YAOPING, EDWARDS, JAMES P, BACANI, GENESIS M, DECKHUT, CHARLOTTE POOLEY, WEI, JIANMEI, LI, GANG, TICHENOR, MARK S, WIENER, JOHN J. M, GHOSH, BRAHMANANDA, ARORA, NIDHI, KREUTTER, KEVIN D, CHEN, WEI, BARBAY, JOSEPH KENT
Year of Publication 02.01.2024
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Year of Publication 02.01.2024
Patent