A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation
Wu, Fangzhou, Mayer, John P, Gelfanov, Vasily M, Liu, Fa, DiMarchi, Richard D
Published in Journal of organic chemistry (07.04.2017)
Published in Journal of organic chemistry (07.04.2017)
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Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
Altindis, Emrah, Cai, Weikang, Sakaguchi, Masaji, Zhang, Fa, GuoXiao, Wang, Liu, Fa, De Meyts, Pierre, Gelfanov, Vasily, Pan, Hui, DiMarchi, Richard, Kahn, C. Ronald
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2018)
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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists
Yang, Bin, Gelfanov, Vasily M, Perez-Tilve, Diego, DuBois, Barent, Rohlfs, Rebecca, Levy, Jay, Douros, Jonathan D, Finan, Brian, Mayer, John P, DiMarchi, Richard D
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
Finan, Brian, Ma, Tao, Ottaway, Nickki, Müller, Timo D, Habegger, Kirk M, Heppner, Kristy M, Kirchner, Henriette, Holland, Jenna, Hembree, Jazzminn, Raver, Christine, Lockie, Sarah H, Smiley, David L, Gelfanov, Vasily, Yang, Bin, Hofmann, Susanna, Bruemmer, Dennis, Drucker, Daniel J, Pfluger, Paul T, Perez-Tilve, Diego, Gidda, Jaswant, Vignati, Louis, Zhang, Lianshan, Hauptman, Jonathan B, Lau, Michele, Brecheisen, Mathieu, Uhles, Sabine, Riboulet, William, Hainaut, Emmanuelle, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, DiMarchi, Richard D, Tschöp, Matthias H
Published in Science translational medicine (30.10.2013)
Published in Science translational medicine (30.10.2013)
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Journal Article
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity
Liu, Fa, Li, Pengyun, Gelfanov, Vasily, Mayer, John, DiMarchi, Richard
Published in Accounts of chemical research (15.08.2017)
Published in Accounts of chemical research (15.08.2017)
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Journal Article
High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy
Zaykov, Alexander N, Gelfanov, Vasily M, Liu, Fa, DiMarchi, Richard D
Published in Organic letters (15.06.2018)
Published in Organic letters (15.06.2018)
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Journal Article
Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
HABEGGER, Kirk M, STEMMER, Kerstin, KRISHNA, Radha, ARAFAT, Ayman M, KONKAR, Anish, BELLI, Sara, KAPPS, Martin, WOODS, Stephen C, HOFMANN, Susanna M, D'ALESSIO, David, PFLUGER, Paul T, PEREZ-TILVE, Diego, CHENG, Christine, SEELEY, Randy J, KONISHI, Morichika, ITOH, Nobuyujki, KHARITONENKOV, Alexei, SPRANGER, Joachim, DIMARCHI, Richard D, TSCHÖP, Matthias H, MÜLLER, Timo D, HEPPNER, Kristy M, OTTAWAY, Nickki, HOLLAND, Jenna, HEMBREE, Jazzminn L, SMILEY, David, GELFANOV, Vasily
Published in Diabetes (New York, N.Y.) (01.05.2013)
Published in Diabetes (New York, N.Y.) (01.05.2013)
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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
DiMarchi, Richard, Day, Jonathan W, Ottaway, Nickki, Patterson, James T, Gelfanov, Vasily, Smiley, David, Gidda, Jas, Findeisen, Hannes, Bruemmer, Dennis, Drucker, Daniel J, Chaudhary, Nilika, Holland, Jenna, Hembree, Jazzminn, Abplanalp, William, Grant, Erin, Ruehl, Jennifer, Wilson, Hilary, Kirchner, Henriette, Lockie, Sarah Haas, Hofmann, Susanna, Woods, Stephen C, Nogueiras, Ruben, Pfluger, Paul T, Perez-Tilve, Diego, Tschöp, Matthias H
Published in Nature chemical biology (01.10.2009)
Published in Nature chemical biology (01.10.2009)
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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
Moreau, Francois, Kirk, Nicholas S., Zhang, Fa, Gelfanov, Vasily, List, Edward O., Chrudinová, Martina, Venugopal, Hari, Lawrence, Michael C., Jimenez, Veronica, Bosch, Fatima, Kopchick, John J., DiMarchi, Richard D., Altindis, Emrah, Kahn, C. Ronald
Published in Nature communications (05.11.2022)
Published in Nature communications (05.11.2022)
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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
Yang, Bin, Gelfanov, Vasily M, El, Kimberley, Chen, Alex, Rohlfs, Rebecca, DuBois, Barent, Kruse Hansen, Ann Maria, Perez-Tilve, Diego, Knerr, Patrick J, D'Alessio, David, Campbell, Jonathan E, Douros, Jonathan D, Finan, Brian
Published in Molecular metabolism (Germany) (01.12.2022)
Published in Molecular metabolism (Germany) (01.12.2022)
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Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence
Kabotso, Daniel E. K., Smiley, David, Mayer, John P., Gelfanov, Vasily M., Perez-Tilve, Diego, DiMarchi, Richard D., Pohl, Nicola L. B., Liu, Fa
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision
Thalluri, Kishore, Kou, Binbin, Gelfanov, Vasily, Mayer, John P, Liu, Fa, DiMarchi, Richard D
Published in Organic letters (03.02.2017)
Published in Organic letters (03.02.2017)
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Journal Article
Chemical Synthesis of Insulin Analogs through a Novel Precursor
Zaykov, Alexander N, Mayer, John P, Gelfanov, Vasily M, DiMarchi, Richard D
Published in ACS chemical biology (21.03.2014)
Published in ACS chemical biology (21.03.2014)
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Journal Article
A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity
Brunel, Florence M, Mayer, John P, Gelfanov, Vasily M, Zaykov, Alexander N, Finan, Brian, Perez-Tilve, Diego, DiMarchi, Richard D
Published in ACS chemical biology (16.08.2019)
Published in ACS chemical biology (16.08.2019)
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Journal Article
Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5
Zaykov, Alexander N., Gelfanov, Vasily M., Liu, Fa, DiMarchi, Richard D.
Published in ChemMedChem (23.04.2018)
Published in ChemMedChem (23.04.2018)
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