Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
KER YU, SHI, Celine, SUNG KYOO KIM, CONANT, Roger, CURRAN, Kevin, KAPLAN, Joshua, VERHEIJEN, Jeroen, AYRAL-KALOUSTIAN, Semiramis, MANSOUR, Tarek S, ABRAHAM, Robert T, ZASK, Arie, GIBBONS, James J, TORAL-BARZA, Lourdes, LUCAS, Judy, SHOR, Boris, JAE EUN KIM, ZHANG, Wei-Guo, MAHONEY, Robert, GAYDOS, Christine, TARDIO, Luanna
Published in Cancer research (Chicago, Ill.) (15.01.2010)
Published in Cancer research (Chicago, Ill.) (15.01.2010)
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Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin−Rapamycin Conjugates
Ayral-Kaloustian, Semiramis, Gu, Jianxin, Lucas, Judy, Cinque, Michael, Gaydos, Christine, Zask, Arie, Chaudhary, Inder, Wang, Jianyao, Di, Li, Young, Mairead, Ruppen, Mark, Mansour, Tarek S, Gibbons, James J, Yu, Ker
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Yu, Ker, Lucas, Judy, Zhu, Tianmin, Zask, Arie, Gaydos, Christine, Toral-Barza, Lourdes, Gu, Jianxin, Li, Fangbiao, Chaudhary, Inder, Cai, Ping, Lotvin, Jason, Petersen, Roseann, Ruppen, Mark, Fawzi, Mahdi, Ayral-Kaloustian, Semiramis, Skotnicki, Jerauld, Mansour, Tarek, Frost, Philip, Gibbons, James
Published in Cancer biology & therapy (01.05.2005)
Published in Cancer biology & therapy (01.05.2005)
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Synthesis and Structure–Activity Relationships of Ring-Opened 17-Hydroxywortmannins: Potent Phosphoinositide 3-Kinase Inhibitors with Improved Properties and Anticancer Efficacy
Zask, Arie, Kaplan, Joshua, Toral-Barza, Lourdes, Hollander, Irwin, Young, Mairead, Tischler, Mark, Gaydos, Christine, Cinque, Michael, Lucas, Judy, Yu, Ker
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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Updates on canine hypoadrenocorticism: the lack of a stress leukogram in dogs with gastrointestinal signs may signal this potentially life-threatening disease. This review will help ensure that you aren't overlooking other clinical signs and that you know the latest about diagnosing and treating canine hypoadrenocorticism
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