Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
Leader, Andrew M., Grout, John A., Maier, Barbara B., Nabet, Barzin Y., Park, Matthew D., Tabachnikova, Alexandra, Chang, Christie, Walker, Laura, Lansky, Alona, Le Berichel, Jessica, Troncoso, Leanna, Malissen, Nausicaa, Davila, Melanie, Martin, Jerome C., Magri, Giuliana, Tuballes, Kevin, Zhao, Zhen, Petralia, Francesca, Samstein, Robert, D’Amore, Natalie Roy, Thurston, Gavin, Kamphorst, Alice O., Wolf, Andrea, Flores, Raja, Wang, Pei, Müller, Sören, Mellman, Ira, Beasley, Mary Beth, Salmon, Hélène, Rahman, Adeeb H., Marron, Thomas U., Kenigsberg, Ephraim, Merad, Miriam
Published in Cancer cell (13.12.2021)
Published in Cancer cell (13.12.2021)
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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
Kim, Minah, Allen, Breanna, Korhonen, Emilia A, Nitschké, Maximilian, Yang, Hee Won, Baluk, Peter, Saharinen, Pipsa, Alitalo, Kari, Daly, Christopher, Thurston, Gavin, McDonald, Donald M
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Gerhardt, Holger, Jakobsson, Lars, Franco, Claudio A, Bentley, Katie, Collins, Russell T, Ponsioen, Bas, Aspalter, Irene M, Rosewell, Ian, Busse, Marta, Thurston, Gavin, Medvinsky, Alexander, Schulte-Merker, Stefan
Published in Nature cell biology (01.10.2010)
Published in Nature cell biology (01.10.2010)
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Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch
Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizán, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne, Gerhardt, Holger
Published in Nature communications (17.06.2015)
Published in Nature communications (17.06.2015)
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C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice
Atanasio, Amanda, Decman, Vilma, White, Derek, Ramos, Meg, Ikiz, Burcin, Lee, Hoi-Ching, Siao, Chia-Jen, Brydges, Susannah, LaRosa, Elizabeth, Bai, Yu, Fury, Wen, Burfeind, Patricia, Zamfirova, Ralica, Warshaw, Gregg, Orengo, Jamie, Oyejide, Adelekan, Fralish, Michael, Auerbach, Wojtek, Poueymirou, William, Freudenberg, Jan, Gong, Guochun, Zambrowicz, Brian, Valenzuela, David, Yancopoulos, George, Murphy, Andrew, Thurston, Gavin, Lai, Ka-Man Venus
Published in Scientific reports (16.03.2016)
Published in Scientific reports (16.03.2016)
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Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
Phng, Li-Kun, Potente, Michael, Leslie, Jonathan D., Babbage, Jane, Nyqvist, Daniel, Lobov, Ivan, Ondr, Jennifer K., Rao, Sujata, Lang, Richard A., Thurston, Gavin, Gerhardt, Holger
Published in Developmental cell (01.01.2009)
Published in Developmental cell (01.01.2009)
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Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment
Lee, Eunhyeong, O'Keefe, Sophie, Leong, Alessandra, Park, Ha-Ram, Varadarajan, Janani, Chowdhury, Subrata, Hiner, Shannon, Kim, Sungsoo, Shiva, Anahita, Friedman, Richard A, Remotti, Helen, Fojo, Tito, Yang, Hee Won, Thurston, Gavin, Kim, Minah
Published in The Journal of clinical investigation (16.10.2023)
Published in The Journal of clinical investigation (16.10.2023)
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Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade
Eichten, Alexandra, Su, Jia, Adler, Alexander P, Zhang, Li, Ioffe, Ella, Parveen, Asma A, Yancopoulos, George D, Rudge, John, Lowy, Israel, Lin, Hsin Chieh, MacDonald, Douglas, Daly, Christopher, Duan, Xunbao, Thurston, Gavin
Published in Cancer research (Chicago, Ill.) (15.04.2016)
Published in Cancer research (Chicago, Ill.) (15.04.2016)
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The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
Fiedler, Ulrike, Scharpfenecker, Marion, Koidl, Stefanie, Hegen, Anja, Grunow, Verena, Schmidt, Jarno M., Kriz, Wilhelm, Thurston, Gavin, Augustin, Hellmut G.
Published in Blood (01.06.2004)
Published in Blood (01.06.2004)
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Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
Baffert, Fabienne, Le, Tom, Sennino, Barbara, Thurston, Gavin, Kuo, Calvin J, Hu-Lowe, Dana, McDonald, Donald M
Published in American journal of physiology. Heart and circulatory physiology (01.02.2006)
Published in American journal of physiology. Heart and circulatory physiology (01.02.2006)
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Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts
Miles, Kiersten Marie, Seshadri, Mukund, Ciamporcero, Eric, Adelaiye, Remi, Gillard, Bryan, Sotomayor, Paula, Attwood, Kristopher, Shen, Li, Conroy, Dylan, Kuhnert, Frank, Lalani, Alshad S, Thurston, Gavin, Pili, Roberto
Published in PloS one (13.11.2014)
Published in PloS one (13.11.2014)
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Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model
Carbonaro, Marisa, Lee, Jeffrey, Pefanis, Evangelos, Desclaux, Mathieu, Wang, Kehui, Pennington, Alexander, Huang, Hui, Mujica, Alejo, Rojas, Jose, Ally, Roxanne, Kennedy, Daniel, Brown, Michael, Rogulin, Vitaliy, Moller-Tank, Sven, Sabin, Leah, Zambrowicz, Brian, Thurston, Gavin, Li, Zhe
Published in Scientific reports (18.08.2022)
Published in Scientific reports (18.08.2022)
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Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth
NASARRE, Patrick, THOMAS, Markus, KRUSE, Karoline, HELFRICH, Iris, WOLTER, Vivien, DEPPERMANN, Carleen, SCHADENDORF, Dirk, THURSTON, Gavin, FIEDLER, Ulrike, AUGUSTIN, Hellmut G
Published in Cancer research (Chicago, Ill.) (15.02.2009)
Published in Cancer research (Chicago, Ill.) (15.02.2009)
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VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
Hayashi, Makoto, Majumdar, Arindam, Li, Xiujuan, Adler, Jeremy, Sun, Zuyue, Vertuani, Simona, Hellberg, Carina, Mellberg, Sofie, Koch, Sina, Dimberg, Anna, Koh, Gou Young, Dejana, Elisabetta, Belting, Heinz-Georg, Affolter, Markus, Thurston, Gavin, Holmgren, Lars, Vestweber, Dietmar, Claesson-Welsh, Lena
Published in Nature communications (2013)
Published in Nature communications (2013)
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Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution
Deering, Raquel P, Blumenberg, Lili, Li, Lianjie, Dhanik, Ankur, Jeong, Se, Pourpe, Stephane, Song, Hang, Boucher, Lauren, Ragunathan, Shoba, Li, Yanxia, Zhong, Maggie, Kuhnert, Jessica, Adler, Christina, Hawkins, Peter, Gupta, Namita T, Moore, Michael, Ni, Min, Hansen, Johanna, Wei, Yi, Thurston, Gavin
Published in Scientific reports (25.05.2023)
Published in Scientific reports (25.05.2023)
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Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts
Inai, Tetsuichiro, Mancuso, Michael, Hashizume, Hiroya, Baffert, Fabienne, Haskell, Amy, Baluk, Peter, Hu-Lowe, Dana D., Shalinsky, David R., Thurston, Gavin, Yancopoulos, George D., McDonald, Donald M.
Published in The American journal of pathology (01.07.2004)
Published in The American journal of pathology (01.07.2004)
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VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
Rudge, John S, Holash, Jocelyn, Hylton, Donna, Russell, Michelle, Jiang, Shelly, Leidich, Raymond, Papadopoulos, Nicholas, Pyles, Erica A, Torri, Al, Wiegand, Stanley J, Thurston, Gavin, Stahl, Neil, Yancopoulos, George D
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
Kamba, Tomomi, Tam, Betty Y. Y, Hashizume, Hiroya, Haskell, Amy, Sennino, Barbara, Mancuso, Michael R, Norberg, Scott M, O'Brien, Shaun M, Davis, Rachel B, Gowen, Lori C, Anderson, Keith D, Thurston, Gavin, Joho, Shuji, Springer, Matthew L, Kuo, Calvin J, McDonald, Donald M
Published in American journal of physiology. Heart and circulatory physiology (01.02.2006)
Published in American journal of physiology. Heart and circulatory physiology (01.02.2006)
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