Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype
Tarantini, Stefano, Valcarcel-Ares, M Noa, Yabluchanskiy, Andriy, Tucsek, Zsuzsanna, Hertelendy, Peter, Kiss, Tamas, Gautam, Tripti, Zhang, Xin A, Sonntag, William E, de Cabo, Rafael, Farkas, Eszter, Elliott, Michael H, Kinter, Michael T, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (14.06.2018)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (14.06.2018)
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase
Toth, Peter, Tarantini, Stefano, Tucsek, Zsuzsanna, Ashpole, Nicole M, Sosnowska, Danuta, Gautam, Tripti, Ballabh, Praveen, Koller, Akos, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in American journal of physiology. Heart and circulatory physiology (01.02.2014)
Published in American journal of physiology. Heart and circulatory physiology (01.02.2014)
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Journal Article
Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
Ungvari, Zoltan, Bailey-Downs, Lora, Gautam, Tripti, Jimenez, Rosario, Losonczy, Gyorgy, Zhang, Cuihua, Ballabh, Praveen, Recchia, Fabio A, Wilkerson, Donald C, Sonntag, William E, Pearson, Kevin, de Cabo, Rafael, Csiszar, Anna
Published in American journal of physiology. Heart and circulatory physiology (01.04.2011)
Published in American journal of physiology. Heart and circulatory physiology (01.04.2011)
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Journal Article
Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells
Banki, Eszter, Sosnowska, Danuta, Tucsek, Zsuzsanna, Gautam, Tripti, Toth, Peter, Tarantini, Stefano, Tamas, Andrea, Helyes, Zsuzsanna, Reglodi, Dora, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.06.2015)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.06.2015)
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer
Podlutsky, Andrej, Valcarcel-Ares, Marta Noa, Yancey, Krysta, Podlutskaya, Viktorija, Nagykaldi, Eszter, Gautam, Tripti, Miller, Richard A., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Published in GeroScience (01.04.2017)
Published in GeroScience (01.04.2017)
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Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects
Miller, Lauren R., Bickel, Marisa A., Vance, Michaela L., Vaden, Hannah, Nagykaldi, Domonkos, Nyul-Toth, Adam, Bullen, Elizabeth C., Gautam, Tripti, Tarantini, Stefano, Yabluchanskiy, Andriy, Kiss, Tamas, Ungvari, Zoltan, Conley, Shannon M.
Published in GeroScience (01.06.2024)
Published in GeroScience (01.06.2024)
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Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension
Toth, Peter, Tucsek, Zsuzsanna, Sosnowska, Danuta, Gautam, Tripti, Mitschelen, Matthew, Tarantini, Stefano, Deak, Ferenc, Koller, Akos, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in Journal of cerebral blood flow and metabolism (01.11.2013)
Published in Journal of cerebral blood flow and metabolism (01.11.2013)
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Journal Article
Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response
Ungvari, Zoltan, Bailey-Downs, Lora, Sosnowska, Danuta, Gautam, Tripti, Koncz, Peter, Losonczy, Gyorgy, Ballabh, Praveen, de Cabo, Rafael, Sonntag, William E, Csiszar, Anna
Published in American journal of physiology. Heart and circulatory physiology (01.08.2011)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2011)
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Journal Article
Treatment with the mitochondrial‐targeted antioxidant peptide SS‐31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice
Tarantini, Stefano, Valcarcel‐Ares, Noa M., Yabluchanskiy, Andriy, Fulop, Gabor A., Hertelendy, Peter, Gautam, Tripti, Farkas, Eszter, Perz, Aleksandra, Rabinovitch, Peter S., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Published in Aging cell (01.04.2018)
Published in Aging cell (01.04.2018)
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Journal Article
Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
Tucsek, Zsuzsanna, Toth, Peter, Sosnowska, Danuta, Gautam, Tripti, Mitschelen, Matthew, Koller, Akos, Szalai, Gabor, Sonntag, William E, Ungvari, Zoltan, Csiszar, Anna
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.10.2014)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.10.2014)
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Journal Article
IGF-1 Deficiency Impairs Cerebral Myogenic Autoregulation in Hypertensive Mice
Toth, Peter, Tucsek, Zsuzsanna, Tarantini, Stefano, Sosnowska, Danuta, Gautam, Tripti, Mitschelen, Matthew, Koller, Akos, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in Journal of cerebral blood flow and metabolism (01.12.2014)
Published in Journal of cerebral blood flow and metabolism (01.12.2014)
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Journal Article
Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats
Csiszar, Anna, Gautam, Tripti, Sosnowska, Danuta, Tarantini, Stefano, Banki, Eszter, Tucsek, Zsuzsanna, Toth, Peter, Losonczy, Gyorgy, Koller, Akos, Reglodi, Dora, Giles, Cory B, Wren, Jonathan D, Sonntag, William E, Ungvari, Zoltan
Published in American journal of physiology. Heart and circulatory physiology (01.08.2014)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2014)
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Journal Article
Aging exacerbates hypertension‐induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection
Toth, Peter, Tarantini, Stefano, Springo, Zsolt, Tucsek, Zsuzsanna, Gautam, Tripti, Giles, Cory B., Wren, Jonathan D., Koller, Akos, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Published in Aging cell (01.06.2015)
Published in Aging cell (01.06.2015)
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Journal Article
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline
Valcarcel-Ares, Marta Noa, Tucsek, Zsuzsanna, Kiss, Tamas, Giles, Cory B, Tarantini, Stefano, Yabluchanskiy, Andriy, Balasubramanian, Priya, Gautam, Tripti, Galvan, Veronica, Ballabh, Praveen, Richardson, Arlan, Freeman, Willard M, Wren, Jonathan D, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (15.02.2019)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (15.02.2019)
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Journal Article
Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice
Toth, Peter, Csiszar, Anna, Tucsek, Zsuzsanna, Sosnowska, Danuta, Gautam, Tripti, Koller, Akos, Schwartzman, Michal Laniado, Sonntag, William E, Ungvari, Zoltan
Published in American journal of physiology. Heart and circulatory physiology (01.12.2013)
Published in American journal of physiology. Heart and circulatory physiology (01.12.2013)
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Journal Article
Insulin‐like growth factor 1 deficiency exacerbates hypertension‐induced cerebral microhemorrhages in mice, mimicking the aging phenotype
Tarantini, Stefano, Valcarcel‐Ares, Noa M., Yabluchanskiy, Andriy, Springo, Zsolt, Fulop, Gabor A., Ashpole, Nicole, Gautam, Tripti, Giles, Cory B., Wren, Jonathan D., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Published in Aging cell (01.06.2017)
Published in Aging cell (01.06.2017)
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Journal Article
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects
Kiss, Tamas, Giles, Cory B., Tarantini, Stefano, Yabluchanskiy, Andriy, Balasubramanian, Priya, Gautam, Tripti, Csipo, Tamas, Nyúl-Tóth, Ádám, Lipecz, Agnes, Szabo, Csaba, Farkas, Eszter, Wren, Jonathan D., Csiszar, Anna, Ungvari, Zoltan
Published in GeroScience (01.08.2019)
Published in GeroScience (01.08.2019)
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Journal Article
Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells
Ungvari, Zoltan, Tucsek, Zsuzsanna, Sosnowska, Danuta, Toth, Peter, Gautam, Tripti, Podlutsky, Andrej, Csiszar, Agnes, Losonczy, Gyorgy, Valcarcel-Ares, M Noa, Sonntag, William E, Csiszar, Anna
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.08.2013)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.08.2013)
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Journal Article
Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity
Ungvari, Zoltan, Podlutsky, Andrej, Sosnowska, Danuta, Tucsek, Zsuzsanna, Toth, Peter, Deak, Ferenc, Gautam, Tripti, Csiszar, Anna, Sonntag, William E
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.12.2013)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.12.2013)
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Journal Article
Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease
Csiszar, Anna, Tucsek, Zsuzsanna, Toth, Peter, Sosnowska, Danuta, Gautam, Tripti, Koller, Akos, Deak, Ferenc, Sonntag, William E, Ungvari, Zoltan
Published in American journal of physiology. Heart and circulatory physiology (15.10.2013)
Published in American journal of physiology. Heart and circulatory physiology (15.10.2013)
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Journal Article