Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders
Gaudino, Stephen J., Singh, Ankita, Huang, Huakang, Padiadpu, Jyothi, Jean-Pierre, Makheni, Kempen, Cody, Bahadur, Tej, Shiomitsu, Kiyoshi, Blumberg, Richard, Shroyer, Kenneth R., Beyaz, Semir, Shulzhenko, Natalia, Morgun, Andrey, Kumar, Pawan
Published in Nature communications (21.02.2024)
Published in Nature communications (21.02.2024)
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IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation
Singh, Ankita, Beaupre, Michael, Villegas-Novoa, Cecilia, Shiomitsu, Kiyoshi, Gaudino, Stephen J., Tawch, Suzanne, Damle, Ruhee, Kempen, Cody, Choudhury, Biswa, McAleer, Jeremy P., Sheridan, Brian S., Denoya, Paula, Blumberg, Richard S., Hearing, Patrick, Allbritton, Nancy L., Kumar, Pawan
Published in Cell reports (Cambridge) (28.05.2024)
Published in Cell reports (Cambridge) (28.05.2024)
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IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation
Singh, Ankita, Beaupre, Michael, Villegas-Novoa, Cecilia, Shiomitsu, Kiyoshi, Gaudino, Stephen J., Tawch, Suzanne, Damle, Ruhee, Kempen, Cody, Choudhury, Biswa, McAleer, Jeremy P., Sheridan, Brian S., Denoya, Paula, Blumberg, Richard S., Hearing, Patrick, Allbritton, Nancy L., Kumar, Pawan
Published in Cell reports (Cambridge) (27.08.2024)
Published in Cell reports (Cambridge) (27.08.2024)
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The role of epidemiology in informing United States childhood immunization policy and practice
Carter-Pokras, O., Hutchins, S., Gaudino, J.A., Veeranki, S.P., Lurie, P., Weiser, T., DeMarco, M., Khan, N.F., Cordero, J.F.
Published in Annals of epidemiology (01.10.2021)
Published in Annals of epidemiology (01.10.2021)
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Characterizing a “Big Data” Cohort of Over 200,000 Low-Income U.S. Infants and Children for Obesity Research: The ADVANCE Early Life Cohort
Boone-Heinonen, J., Tillotson, C. J., O’Malley, J. P., Cottrell, E. K., Gaudino, J. A., Amofah, A., Rivo, M. L., Brickman, A., Mayer, K., McBurnie, M. A., Gold, R., DeVoe, J. E.
Published in Maternal and child health journal (01.03.2017)
Published in Maternal and child health journal (01.03.2017)
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The role of epidemiologists in SARS-CoV-2 and COVID-19 research
Oremus, M., Taylor-Wilson, R., Aldrich, M., Bell, K., Gaudino, J., Palevsky, S., Payne, J., Raynes-Greenow, C., Sim, F., Smith, M., Weiss, S., Zhang, Y.
Published in Public health (London) (01.01.2021)
Published in Public health (London) (01.01.2021)
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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Cutting Edge: Intestinal IL-17A Receptor Signaling Specifically Regulates High-Fat Diet–Mediated, Microbiota-Driven Metabolic Disorders
Gaudino, Stephen J., Huang, Huakang, Jean-Pierre, Makheni, Joshi, Preet, Beaupre, Michael, Kempen, Cody, Wong, Hoi Tong, Kumar, Pawan
Published in The Journal of immunology (1950) (15.10.2021)
Published in The Journal of immunology (1950) (15.10.2021)
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IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
Lin, Xun, Gaudino, Stephen J., Jang, Kyung Ku, Bahadur, Tej, Singh, Ankita, Banerjee, Anirban, Beaupre, Michael, Chu, Timothy, Wong, Hoi Tong, Kim, Chang-Kyung, Kempen, Cody, Axelrad, Jordan, Huang, Huakang, Khalid, Saba, Shah, Vyom, Eskiocak, Onur, Parks, Olivia B., Berisha, Artan, McAleer, Jeremy P., Good, Misty, Hoshino, Miko, Blumberg, Richard, Bialkowska, Agnieszka B., Gaffen, Sarah L., Kolls, Jay K., Yang, Vincent W., Beyaz, Semir, Cadwell, Ken, Kumar, Pawan
Published in Immunity (Cambridge, Mass.) (08.02.2022)
Published in Immunity (Cambridge, Mass.) (08.02.2022)
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IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
Gaudino, Stephen J., Beaupre, Michael, Lin, Xun, Joshi, Preet, Rathi, Sonika, McLaughlin, Patrick A., Kempen, Cody, Mehta, Neil, Eskiocak, Onur, Yueh, Brian, Blumberg, Richard S., van der Velden, Adrianus W. M., Shroyer, Kenneth R., Bialkowska, Agnieszka B., Beyaz, Semir, Kumar, Pawan
Published in Mucosal immunology (01.03.2021)
Published in Mucosal immunology (01.03.2021)
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Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists
Newhouse, Bradley, Allen, Shelley, Fauber, Benjamin, Anderson, Aaron S., Eary, C. Todd, Hansen, Joshua D., Schiro, Justin, Gaudino, John J., Laird, Ellen, Chantry, David, Eberhardt, Christine, Burgess, Laurence E.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
Drilon, Alexander, Sharma, Manish R, Johnson, Melissa L, Yap, Timothy A, Gadgeel, Shirish, Nepert, Dale, Feng, Gang, Reddy, Micaela B, Harney, Allison S, Elsayed, Mohamed, Cook, Adam W, Wong, Christina E, Hinklin, Ronald J, Jiang, Yutong, Brown, Eric N, Neitzel, Nickolas A, Laird, Ellen R, Wu, Wen-I, Singh, Anurag, Wei, Ping, Ching, Keith A, Gaudino, John J, Lee, Patrice A, Hartley, Dylan P, Rothenberg, S Michael
Published in Cancer discovery (04.08.2023)
Published in Cancer discovery (04.08.2023)
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Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA
Hicken, Erik J., Brown, Karin, Dwulet, Natalie C., Gaudino, John J., Hansen, Erik P., Hartley, Dylan P., Kowalski, John P., Laird, Ellen R., Lazzara, Nicholas C., Li, Bin, Mou, Tung-Chung, Mutryn, Marie F., Oko, Lauren, Pajk, Spencer, Pipal, Robert W., Rosen, Rachel Z., Shelp, Russell, Singh, Anurag, Wang, Jing, Wise, Courtney E., Wong, Christina, Wong, Jim Y.
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Journal Article
Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA
Hicken, Erik J, Brown, Karin, Dwulet, Natalie C, Gaudino, John J, Hansen, Erik P, Hartley, Dylan P, Kowalski, John P, Laird, Ellen R, Lazzara, Nicholas C, Li, Bin, Mou, Tung-Chung, Mutryn, Marie F, Oko, Lauren, Pajk, Spencer, Pipal, Robert W, Rosen, Rachel Z, Shelp, Russell, Singh, Anurag, Wang, Jing, Wise, Courtney E, Wong, Christina, Wong, Jim Y
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity
Fell, Jay B, Fischer, John P, Baer, Brian R, Ballard, Joshua, Blake, James F, Bouhana, Karyn, Brandhuber, Barbara J, Briere, David M, Burgess, Laurence E, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Davidson, Kevin, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hee, Kenneth, Hicken, Erik J, Hinklin, Ronald J, Marx, Matthew A, Mejia, Macedonio J, Olson, Peter, Savechenkov, Pavel, Sudhakar, Niranjan, Tang, Tony P, Vigers, Guy P, Zecca, Henry, Christensen, James G
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy
Bumpers, Quinn A., Pipal, Robert W., Benz-Weeden, Anna M., Brewster, James T., Cook, Adam, Crooks, Amy L., Cruz, Cole, Dwulet, Natalie C., Gaudino, John J., Golec, Daniel, Harrison, Jacqueline A., Hartley, Dylan P., Hassanien, Sherif H., Hicken, Erik J., Kahn, Dean, Laird, Ellen R., Lemieux, Christine, Lewandowski, Nicholas, McCown, Joseph, McDonald, Matthew G., McNulty, Oren, Mou, Tung-Chung, Nguyen, Phong, Oko, Lauren, Opie, Lisa Pieti, Otten, Jennifer, Peck, Spencer C., Polites, Viktor C., Randall, Samuel D., Rosen, Rachel Z., Savechenkov, Pavel, Simpson, Helen, Singh, Anurag, Sparks, Drew, Wickersham, Kyle, Wollenberg, Lance, Wong, Christina E., Wong, Jim, Wu, Wen-I, Elsayed, Mohamed S. A., Hinklin, Ronald J., Tang, Tony P.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation
Yaeger, Rona, McKean, Meredith A, Haq, Rizwan, Beck, J Thaddeus, Taylor, Matthew H, Cohen, Jonathan E, Bowles, Daniel W, Gadgeel, Shirish M, Mihalcioiu, Catalin, Papadopoulos, Kyriakos P, Diamond, Eli L, Sturtz, Keren B, Feng, Gang, Drescher, Stefanie K, Reddy, Micaela B, Sengupta, Bhaswati, Maity, Arnab K, Brown, Suzy A, Singh, Anurag, Brown, Eric N, Baer, Brian R, Wong, Jim, Mou, Tung-Chung, Wu, Wen-I, Kahn, Dean R, Gadal, Sunyana, Rosen, Neal, Gaudino, John J, Lee, Patrice A, Hartley, Dylan P, Rothenberg, S Michael
Published in Cancer discovery (04.09.2024)
Published in Cancer discovery (04.09.2024)
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