SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog
PERKINS, W. E, BURTON, E. G, TSAI, B. S, COLLINS, P. W, CASLER, J. J, GASIECKI, A. F, BAUER, R. F, JONES, P. H, GAGINELLA, T. S
Published in The Journal of pharmacology and experimental therapeutics (01.12.1991)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1991)
Journal Article
Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation
Fretland, D J, Widomski, D L, Anglin, C P, Walsh, R E, Levin, S, Gasiecki, A F, Collins, P W
Published in Inflammation (01.12.1992)
Published in Inflammation (01.12.1992)
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Journal Article
Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin
Collins, P. W, Gasiecki, A. F, Perkins, W. E, Gullikson, G. W, Bianchi, R. G, Kramer, S. W, Ng, J. S, Yonan, E. E, Swenton, L
Published in Journal of medicinal chemistry (01.10.1990)
Published in Journal of medicinal chemistry (01.10.1990)
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Journal Article
Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach
Tremont, Samuel J, Collins, Paul W, Perkins, William E, Fenton, Rick L, Forster, Denis, McGrath, Martin P, Wagner, Grace M, Gasiecki, Alan F, Bianchi, Robert G
Published in Journal of medicinal chemistry (15.10.1993)
Published in Journal of medicinal chemistry (15.10.1993)
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Journal Article
CHARACTERIZATION OF PROSTAGLANDIN-E RECEPTORS IN CANINE SMALL-INTESTINE USING [3H] PROSTAGLANDIN-E1 BINDING
KEITH, RH, TSAI, BS, COLLINS, PW, PERKINS, WE, SHONE, RL, GASIECKI, AF, BIANCHI, RG, BAUER, RF
Published in Prostaglandins (01.12.1992)
Published in Prostaglandins (01.12.1992)
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Journal Article
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem
PERKINS, W. E, BIANCHI, R. G, GASIECKI, A. F, FORSTER, D, JONES, P. H, TREMONT, S. J, COLLINS, P. W, CASLER, J. J, FENTON, R. L, WAGNER, G. M, MCGRATH, M. P, STOLZENBACH, J. C, KOWALSKI, D. L
Published in The Journal of pharmacology and experimental therapeutics (01.04.1994)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1994)
Journal Article
Structure-activity relationship studies on 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase
Penning, TD, Chandrakumar, NS, Chen, BB, Chen, HY, Desai, BN, Djuric, SW, Docter, SH, Gasiecki, AF, Haack, RA, Miyashiro, JM, Russell, MA, Yu, SS, Corley, DG, Durley, RC, Kilpatrick, BF, Parnas, BL, Askonas, LJ, Gierse, JK, Harding, EI, Highkin, MK, Kachur, JF, Kim, SH, Krivi, GG, Villani-Price, D, Pyla, EY, Smith, WG, Ghoreishi-Haack, NS
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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Journal Article
18-Cycloalkyl analogs of enisoprost
Collins, Paul W, Gasiecki, Alan F, Perkins, William E, Gullikson, Gary W, Jones, Peter H, Bauer, Raymond F
Published in Journal of medicinal chemistry (01.05.1989)
Published in Journal of medicinal chemistry (01.05.1989)
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Journal Article
Conference Proceeding
Synthesis and gastrointestinal pharmacology of a 3E,5Z diene analog of misoprostol
Collins, Paul W, Kramer, Steven W, Gasiecki, Alan F, Weier, Richard M, Jones, Peter H, Gullikson, Gary W, Bianchi, Robert G, Bauer, Raymond F
Published in Journal of medicinal chemistry (01.01.1987)
Published in Journal of medicinal chemistry (01.01.1987)
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Journal Article
Synthesis and gastric antisecretory properties of .alpha.-chain diene derivatives of misoprostol
Collins, Paul W, Gasiecki, Alan F, Jones, Peter H, Bauer, Raymond F, Gullikson, Gary W, Woods, Emmett M, Bianchi, Robert G
Published in Journal of medicinal chemistry (01.07.1986)
Published in Journal of medicinal chemistry (01.07.1986)
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Journal Article
1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel
Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Journal Article
Redox glycosidation: a new strategy for disaccharide synthesis
Barrett, Anthony G. M, Bezuidenhoudt, Barend C. B, Gasiecki, Alan F, Howell, Amy R, Russell, Mark A
Published in Journal of the American Chemical Society (01.02.1989)
Published in Journal of the American Chemical Society (01.02.1989)
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Journal Article
Stabilization of a prostaglandin tertiary allylic alcohol system by fluorine: synthesis, acid stability studies and pharmacology of a 16-fluoromethyl analog of SC-46275
Collins, P.W., Shone, R.L., Gasiecki, A.F., Kramer, S.W., Perkins, W.E., Bianchi, R.G.
Published in Bioorganic & medicinal chemistry letters (01.12.1992)
Published in Bioorganic & medicinal chemistry letters (01.12.1992)
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Journal Article
Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase
Penning, Thomas D, Chandrakumar, Nizal S, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Djuric, Stevan W, Docter, Stephen H, Gasiecki, Alan F, Haack, Richard A, Miyashiro, Julie M, Russell, Mark A, Yu, Stella S, Corley, David G, Durley, Richard C, Kilpatrick, Brian F, Parnas, Barry L, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Krivi, Gwen G, Villani-Price, Doreen, Pyla, E. Yvonne, Smith, Walter G, Ghoreishi-Haack, Nayereh S
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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Journal Article