Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain
Bare, Thomas M, Brown, Dean G, Horchler, Carey L, Murphy, Megan, Urbanek, Rebecca A, Alford, Vernon, Barlaam, Christine, Dyroff, Martin C, Empfield, James B, Forst, Janet M, Herzog, Keith J, Keith, Richard A, Kirschner, Alan S, Lee, Chi-Ming C, Lewis, Joseph, McLaren, Frances M, Neilson, Kathy L, Steelman, Gary B, Trivedi, Shephali, Vacek, Edward P, Xiao, Wenhua
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase
Veale, Chris A, Bernstein, Peter R, Bohnert, Claudia M, Brown, Frederick J, Bryant, Craig, Damewood, James R, Earley, Roger, Feeney, Scott W, Edwards, Philip D, Gomes, Bruce, Hulsizer, James M, Kosmider, Ben J, Krell, Robert D, Moore, Gary, Salcedo, Theodora W, Shaw, Andrew, Silberstein, David S, Steelman, Gary B, Stein, Mark, Strimpler, Anne, Thomas, Roy M, Vacek, Edward P, Williams, Joseph C, Wolanin, Donald J, Woolson, Sheila
Published in Journal of medicinal chemistry (26.09.1997)
Published in Journal of medicinal chemistry (26.09.1997)
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Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists
BROWN, Dean G, URBANEK, Rebecca A, XIAO, Wenhua, DYROFF, Martin C, LEE, Chi-Ming C, TRIVEDI, Shephali, NEILSON, Kathy L, KEITH, Richard A, BARE, Thomas M, MCLAREN, Frances M, HORCHLER, Carey L, MURPHY, Megan, STEELMAN, Gary B, EMPFIELD, James R, FORST, Janet M, HERZOG, Keith J
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. part 1
Veale, Chris A, Alford, Vernon C, Aharony, David, Banville, Debra L, Bialecki, Russell A, Brown, Frederick J, Damewood, James R, Dantzman, Cathy L, Edwards, Philip D, Jacobs, Robert T, Mauger, Russell C, Murphy, Megan M, Palmer, Willam E, Pine, Kara K, Rumsey, William L, Garcia-Davenport, Laura E, Shaw, Andrew, Steelman, Gary B, Surian, Jean M, Vacek, Edward P
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of .beta.-carbolinone-containing trifluoromethyl ketones
Veale, Chris A, Damewood, James R. Jr, Steelman, Gary B, Bryant, Craig, Gomes, Bruce, Williams, Joseph
Published in Journal of medicinal chemistry (01.01.1995)
Published in Journal of medicinal chemistry (01.01.1995)
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Efficient method for the synthesis of 1,4-disubstituted 5-carbomethoxypyrimidin-6-ones
Veale, Chris A, Steelman, Gary B, Chow, Margaret M
Published in Journal of organic chemistry (01.07.1993)
Published in Journal of organic chemistry (01.07.1993)
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Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D-2 partial agonists
Urbanek, Rebecca A., Xiong, Hui, Wu, Ye, Blackwell, William, Steelman, Gary, Rosamond, Jim, Wesolowski, Steven S., Campbell, James B., Zhang, Minli, Brockel, Becky, Widzowski, Daniel V.
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist
Xiong, Hui, Wu, Ye, Lehr, Scott G., Blackwell, William, Steelman, Gary, Hulsizer, Jim, Urbanek, Rebecca A.
Published in Tetrahedron letters (31.10.2012)
Published in Tetrahedron letters (31.10.2012)
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Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D₂ partial agonists
Urbanek, Rebecca A, Xiong, Hui, Wu, Ye, Blackwell, William, Steelman, Gary, Rosamond, Jim, Wesolowski, Steven S, Campbell, James B, Zhang, Minli, Brockel, Becky, Widzowski, Daniel V
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Nonpeptidic Inhibitors of Human Leukocyte Elastase. 2. Design, Synthesis, and in vitro Activity of a Series of 3-Amino-6-aryl-2-oxopyridyl Trifluoromethyl Ketones
Damewood, James R, Edwards, Philip D, Feeney, Scott, Gomes, Bruce C, Steelman, Gary B, Tuthill, Paul A, Williams, Joseph C, Warner, Peter, Woolson, Sheila A
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase
Edwards, Philip D, Andisik, Donald W, Bryant, Craig A, Ewing, Barbara, Gomes, Bruce, Lewis, Joseph J, Rakiewicz, Donna, Steelman, Gary, Strimpler, Ann, Trainor, Diane A, Tuthill, Paul A, Mauger, Russell C, Veale, Chris A, Wildonger, Richard A, Williams, Joseph C, Wolanin, Donald J, Zottola, Mark
Published in Journal of medicinal chemistry (06.06.1997)
Published in Journal of medicinal chemistry (06.06.1997)
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Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and x-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones
Veale, Chris A, Bernstein, Peter R, Bryant, Craig, Ceccarelli, Christopher, Damewood, James R. Jr, Earley, Roger, Feeney, Scott W, Gomes, Bruce, Kosmider, Ben J
Published in Journal of medicinal chemistry (01.01.1995)
Published in Journal of medicinal chemistry (01.01.1995)
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Journal Article
Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase
Brown, Frederick J, Andisik, Donald W, Bernstein, Peter R, Bryant, Craig B, Ceccarelli, Chris, Damewood, James R. Jr, Edwards, Philip D, Earley, Roger A, Feeney, Scott
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
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NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A SERIES OF ORALLY-ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
BERNSTEIN, PR, ANDISIK, D, BRADLEY, PK, BRYANT, CB, CECCARELLI, C, DAMEWOOD, EARLEY, R, EDWARDS, PD, FEENEY, S, GOMES, BC, KOSMIDER, BJ, STEELMAN, GB, THOMAS, RM, VACEK, EP, VEALE, CA, WILLIAMS, JC, WOLANIN, DJ, WOOLSON, SA
Published in Journal of medicinal chemistry (30.09.1994)
Published in Journal of medicinal chemistry (30.09.1994)
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NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .2. DESIGN, SYNTHESIS, AND IN-VITRO ACTIVITY OF A SERIES OF 3-AMINO-6-ARYLOPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
DAMEWOOD, EDWARDS, PD, FEENEY, S, GOMES, BC, STEELMAN, GB, TUTHILL, PA, WILIIAMS, JC, WARNER, P, WOOLSON, SA, WOLANIN, DJ, VEALE, CA
Published in Journal of medicinal chemistry (30.09.1994)
Published in Journal of medicinal chemistry (30.09.1994)
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