Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Lu, Jing, Zavorotinskaya, Tatiana, Dai, Yumin, Niu, Xiao-Hong, Castillo, Joseph, Sim, Janet, Yu, Jianjun, Wang, Yingyun, Langowski, John L., Holash, Jocelyn, Shannon, Kevin, Garcia, Pablo D.
Published in Blood (29.08.2013)
Published in Blood (29.08.2013)
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Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
GARCIA, Pablo D, LANGOWSKI, John L, NIU, Xiao-Hong, BASHAM, Stephen, CHAN, Julie, JIANJUN YU, DOYLE, Michael, FEUCHT, Paul, WARNE, Robert, NARBERES, Jamie, TSANG, Tiffany, FRITSCH, Christine, YINGYUN WANG, KAUFFMANN, Audrey, PFISTER, Estelle, DRUECKES, Peter, TRAPPE, Joerg, WILSON, Christopher, WOOSEOK HAN, JIONG LAN, NISHIGUCHI, Gisele, LINDVALL, Mika, BELLAMACINA, Cornelia, MIN CHEN, AYCINENA, J. Alex, ZANG, Richard, HOLASH, Jocelyn, BURGER, Matthew T, CASTILLO, Joseph, FANTON, Christie, ISON, Marjorie, ZAVOROTINSKAYA, Tatiana, YUMIN DAI, JING LU
Published in Clinical cancer research (01.04.2014)
Published in Clinical cancer research (01.04.2014)
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Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies
Burger, Matthew T, Nishiguchi, Gisele, Han, Wooseok, Lan, Jiong, Simmons, Robert, Atallah, Gordana, Ding, Yu, Tamez, Victoriano, Zhang, Yanchen, Mathur, Michelle, Muller, Kristine, Bellamacina, Cornelia, Lindvall, Mika K, Zang, Richard, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Basham, Steve, Chan, Julie, Ginn, Elaine, Aycinena, Alex, Holash, Jocelyn, Castillo, Joseph, Langowski, John L, Wang, Yingyun, Chen, Min Y, Lambert, Amy, Fritsch, Christine, Kauffmann, Audry, Pfister, Estelle, Vanasse, K. Gary, Garcia, Pablo D
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Light-induced modulation of viscoelastic properties in azobenzene polymers
Chiodini, Stefano, Borbone, Fabio, Oscurato, Stefano L., Garcia, Pablo D., Ambrosio, Antonio
Published in Nanophotonics (Berlin, Germany) (01.01.2024)
Published in Nanophotonics (Berlin, Germany) (01.01.2024)
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Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases
Nishiguchi, Gisele A., Atallah, Gordana, Bellamacina, Cornelia, Burger, Matthew T., Ding, Yu, Feucht, Paul H., Garcia, Pablo D., Han, Wooseok, Klivansky, Liana, Lindvall, Mika
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors
Burger, Matthew T, Han, Wooseok, Lan, Jiong, Nishiguchi, Gisele, Bellamacina, Cornelia, Lindval, Mika, Atallah, Gordana, Ding, Yu, Mathur, Michelle, McBride, Chris, Beans, Elizabeth L, Muller, Kristine, Tamez, Victoriano, Zhang, Yanchen, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Holash, Jocelyn, Castillo, Joseph, Langowski, John, Wang, Yingyun, Chen, Min Y, Garcia, Pablo D
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Journal Article
β-catenin regulates vascular endothelial growth factor expression in colon cancer
EASWARAN, Vijay, LEE, Sang H, RANDAZZO, Filippo, GUNDEL, Robert, WARREN, Robert S, ESCOBEDO, Jaime, AUKERMAN, Sharon L, TAYLOR, Robert N, FANTL, Wendy J, INGE, Landon, LIDA GUO, GOLDBECK, Cheryl, GARRETT, Evelyn, WIESMANN, Marion, GARCIA, Pablo D, FULLER, John H, CHAN, Vivien
Published in Cancer research (Chicago, Ill.) (15.06.2003)
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Published in Cancer research (Chicago, Ill.) (15.06.2003)
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Elevated Expression of axin2 and hnkd mRNA Provides Evidence That Wnt/β-Catenin Signaling is Activated in Human Colon Tumors
Yan, Dong, Wiesmann, Marion, Rohan, Michael, Chan, Vivien, Jefferson, Ann B., Guo, Lida, Sakamoto, Doreen, Caothien, Roger H., Fuller, John H., Reinhard, Christoph, Garcia, Pablo D., Randazzo, Filippo M., Escobedo, Jaime, Fantl, Wendy J., Williams, Lewis T.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
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Journal Article
Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity
Singh, Shilpa, Gleason, Catherine E, Fang, Min, Laimon, Yasmin N, Khivansara, Vishal, Xie, Shanhai, Durmaz, Yavuz T, Sarkar, Aniruddha, Ngo, Kenneth, Savla, Varunika, Li, Yixiang, Abu-Remaileh, Muhannad, Li, Xinyue, Tuladhar, Bishma, Odeh, Ranya, Hamkins-Indik, Frances, He, Daphne, Membreno, Miles W, Nosrati, Meisam, Gushwa, Nathan N, Leung, Siegfried S F, Fraga-Walton, Breena, Hernandez, Luis, Baldomero, Miguel P, Lent, Bryan M, Spellmeyer, David, Luna, Joshua F, Hoang, Dalena, Gritsenko, Yuliana, Chand, Manesh, DeMart, Megan K, Metobo, Sammy, Bhatt, Chinmay, Shapiro, Justin A, Yang, Kai, Dupper, Nathan J, Bockus, Andrew T, Doench, John G, Aggen, James B, Liu, Li-Fen, Levin, Bernard, Wang, Evelyn W, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt, Gokhale, Prafulla C, Signoretti, Sabina, Spektor, Alexander, Kreatsoulas, Constantine, Singh, Rajinder, Earp, David J, Garcia, Pablo D, Nijhawan, Deepak, Oser, Matthew G
Published in bioRxiv (01.08.2024)
Published in bioRxiv (01.08.2024)
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Abstract 1559: Mechanisms responsible for hypersensitivity of small cell lung cancers to novel cyclin A and B RxL macrocyclic peptide inhibitors
Singh, Shilpa, Durmaz, Yavuz T., Gleason, Catherine E., Wang, Evelyn W., Singh, Rajinder, Earp, David J., Garcia, Pablo D., Oser, Matthew G.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 5379: Macrocycles inhibiting RxL-mediated binding of substrates to Cyclin A are synthetic lethal in Rb mutated small cell lung carcinoma (SCLC)
Garcia, Pablo D., Gleason, Catherine E., Membreno, Miles, Hamkins-Indik, Frances, Situ, Gavin, Levin, Bernard, Wang, Evelyn W., Leung, Siegfried, Fraga, Breena, Bockus, Andrew, Aggen, James, Spellmeyer, David, Earp, David J., Singh, Rajinder
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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