The importance of synthetic chemistry in the pharmaceutical industry
Campos, Kevin R, Coleman, Paul J, Alvarez, Juan C, Dreher, Spencer D, Garbaccio, Robert M, Terrett, Nicholas K, Tillyer, Richard D, Truppo, Matthew D, Parmee, Emma R
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Published in Science (American Association for the Advancement of Science) (18.01.2019)
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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates
Kern, Jeffrey C, Cancilla, Mark, Dooney, Deborah, Kwasnjuk, Kristen, Zhang, Rena, Beaumont, Maribel, Figueroa, Isabel, Hsieh, SuChun, Liang, Linda, Tomazela, Daniela, Zhang, Jeffrey, Brandish, Philip E, Palmieri, Anthony, Stivers, Peter, Cheng, Mangeng, Feng, Guo, Geda, Prasanthi, Shah, Sanjiv, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Schultz, Peter G, Sun, Ying, Garbaccio, Robert M
Published in Journal of the American Chemical Society (03.02.2016)
Published in Journal of the American Chemical Society (03.02.2016)
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Concise Asymmetric Syntheses of Radicicol and Monocillin I
Garbaccio, Robert M, Stachel, Shawn J, Baeschlin, Daniel K, Danishefsky, Samuel J
Published in Journal of the American Chemical Society (07.11.2001)
Published in Journal of the American Chemical Society (07.11.2001)
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Brnardic, Edward J., Fraley, Mark E., Garbaccio, Robert M., Layton, Mark E., Sanders, John M., Culberson, Chris, Jacobson, Marlene A., Magliaro, Brian C., Hutson, Pete H., O’Brien, Julie A., Huszar, Sarah L., Uslaner, Jason M., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Sur, Sylvie M., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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CC-1065 and the Duocarmycins: Synthetic Studies
Boger, Dale L, Boyce, Christopher W, Garbaccio, Robert M, Goldberg, Joel A
Published in Chemical reviews (08.05.1997)
Published in Chemical reviews (08.05.1997)
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Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol
Yamamoto, Kana, Garbaccio, Robert M., Stachel, Shawn J., Solit, David B., Chiosis, Gabriela, Rosen, Neal, Danishefsky, Samuel J.
Published in Angewandte Chemie (International ed.) (17.03.2003)
Published in Angewandte Chemie (International ed.) (17.03.2003)
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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor
Johns, Douglas G, Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G, Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M, Guetschow, Erik D, Guo, Yan, Ha, Sookhee N, Johnston, Jennifer M, Josien, Hubert, Kauh, Eunkyung A, Koeplinger, Kenneth A, Kuethe, Jeffrey T, Lai, Eseng, Lanning, Christine L, Lee, Anita Y H, Li, Li, Nair, Anilkumar G, O'Neill, Edward A, Stoch, S Aubrey, Thaisrivongs, David A, Tucker, Thomas J, Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P, Volckaert, Bram, Wolford, Dennis G, Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J, Walji, Abbas M, Wood, Harold B
Published in Circulation (New York, N.Y.) (11.07.2023)
Published in Circulation (New York, N.Y.) (11.07.2023)
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Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors
Brnardic, Edward J., Garbaccio, Robert M., Fraley, Mark E., Tasber, Edward S., Steen, Justin T., Arrington, Kenneth L., Dudkin, Vadim Y., Hartman, George D., Stirdivant, Steven M., Drakas, Bob A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Hardwick, James, Tao, Weikang, Beck, Stephen C., Mao, Xianzhi, Lobell, Robert B., Sepp-Lorenzino, Laura, Yan, Youwei, Ikuta, Mari, Munshi, Sanjeev K., Kuo, Lawrence C., Kreatsoulas, Constantine
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs
Kern, Jeffrey C., Dooney, Deborah, Zhang, Rena, Liang, Linda, Brandish, Philip E., Cheng, Mangeng, Feng, Guo, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Sun, Ying, Garbaccio, Robert M.
Published in Bioconjugate chemistry (21.09.2016)
Published in Bioconjugate chemistry (21.09.2016)
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Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations
Brown, Zachary Z, Mapelli, Claudio, Farasat, Iman, Shoultz, Alycia V, Johnson, Scott A, Orvieto, Federica, Santoprete, Alessia, Bianchi, Elisabetta, McCracken, Amy Bittner, Chen, Kuanchang, Zhu, Xiaohong, Demma, Mark J, Lacey, Brian M, Canada, Keith A, Garbaccio, Robert M, O’Neil, Jennifer, Walji, Abbas
Published in Journal of organic chemistry (07.02.2020)
Published in Journal of organic chemistry (07.02.2020)
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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index
Pissarnitski, Dmitri A, Kekec, Ahmet, Yan, Lin, Zhu, Yuping, Feng, Danqing D, Huo, Pei, Madsen-Duggan, Christina, Moyes, Christopher R, Nargund, Ravi P, Kelly, Terri, Zhang, Xiaoping, Carballo-Jane, Ester, Gorski, Judith, Zafian, Peter, Qatanani, Mo, Kaarsholm, Niels, Meng, Fanyu, Jia, Xiujuan, Lee, Keun-Joong, Wang, Weixun, Xu, Sherrie, Hohn, Michael J, Iammarino, Michael J, McCoy, Mark A, Okoh, Grace A, Liang, Yingkai, Hollingsworth, Scott A, Erion, Mark D, Kelley, David E, Garbaccio, Robert M, Zhang, Amy, Mu, James, Lin, Songnian
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M., Tasber, Edward S., Neilson, Lou Anne, Coleman, Paul J., Fraley, Mark E., Olson, Christy, Bergman, Jeff, Torrent, Maricel, Buser, Carolyn A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, South, Vicki J., Diehl, Ronald E., Davide, Joseph P., Yan, Youwei, Kuo, Lawrence C., Li, Chunze, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Mahan, Elizabeth A., Slaughter, Donald E., Salata, Joseph J., Kohl, Nancy E., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D, Coleman, Paul J, Breslin, Michael J, Whitman, David B, Garbaccio, Robert M, Fraley, Mark E, Buser, Carolyn A, Walsh, Eileen S, Hamilton, Kelly, Schaber, Michael D, Lobell, Robert B, Tao, Weikang, Davide, Joseph P, Diehl, Ronald E, Abrams, Marc T, South, Vicki J, Huber, Hans E, Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E, Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C, Kohl, Nancy E, Hartman, George D
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Endosomolytic Bioreducible Poly(amido amine disulfide) Polymer Conjugates for the in Vivo Systemic Delivery of siRNA Therapeutics
Parmar, Rubina Giare, Busuek, Marina, Walsh, Eileen S, Leander, Karen R, Howell, Bonnie J, Sepp-Lorenzino, Laura, Kemp, Eric, Crocker, Louis S, Leone, Anthony, Kochansky, Christopher J, Carr, Brian A, Garbaccio, Robert M, Colletti, Steven L, Wang, Weimin
Published in Bioconjugate chemistry (17.04.2013)
Published in Bioconjugate chemistry (17.04.2013)
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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates
Barrett, Stephanie E., Burke, Rob S., Abrams, Marc T., Bason, Carol, Busuek, Marina, Carlini, Edward, Carr, Brian A., Crocker, Louis S., Fan, Haihong, Garbaccio, Robert M., Guidry, Erin N., Heo, Jun H., Howell, Bonnie J., Kemp, Eric A., Kowtoniuk, Robert A., Latham, Andrew H., Leone, Anthony M., Lyman, Michael, Parmar, Rubina G., Patel, Mihir, Pechenov, Sergey Y., Pei, Tao, Pudvah, Nicole T., Raab, Conrad, Riley, Sean, Sepp-Lorenzino, Laura, Smith, Sheri, Soli, Eric D., Staskiewicz, Steven, Stern, Melissa, Truong, Quang, Vavrek, Marissa, Waldman, Jacob H., Walsh, Eileen S., Williams, J. Michael, Young, Stephanie, Colletti, Steven L.
Published in Journal of controlled release (10.06.2014)
Published in Journal of controlled release (10.06.2014)
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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
Converso, Antonella, Hartingh, Timothy, Garbaccio, Robert M., Tasber, Edward, Rickert, Keith, Fraley, Mark E., Yan, Youwei, Kreatsoulas, Constantine, Stirdivant, Steve, Drakas, Bob, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Mao, Xianzhi, Abrams, Marc T., Beck, Stephen C., Tao, Weikang, Lobell, Rob, Sepp-Lorenzino, Laura, Zugay-Murphy, Joan, Sardana, Vinod, Munshi, Sanjeev K., Jezequel-Sur, Sylvie Marie, Zuck, Paul D., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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