pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37
Alaiwa, Mahmoud H. Abou, Reznikov, Leah R., Gansemer, Nicholas D., Sheets, Kelsey A., Horswill, Alexander R., Stoltz, David A., Zabner, Joseph, Welsh, Michael J.
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
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Gel-forming mucins form distinct morphologic structures in airways
Ostedgaard, Lynda S., Moninger, Thomas O., McMenimen, James D., Sawin, Nicholas M., Parker, Connor P., Thornell, Ian M., Powers, Linda S., Gansemer, Nicholas D., Bouzek, Drake C., Cook, Daniel P., Meyerholz, David K., Alaiwa, Mahmoud H. Abou, Stoltz, David A., Welsh, Michael J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (27.06.2017)
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Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth
Rogan, Mark P., Reznikov, Leah R., Pezzulo, Alejandro A., Gansemer, Nicholas D., Samuel, Melissa, Prather, Randall S., Zabner, Joseph, Fredericks, Douglas C., McCray, Paul B., Welsh, Michael J., Stoltz, David A.
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2010)
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Lack of airway submucosal glands impairs respiratory host defenses
Ostedgaard, Lynda S, Price, Margaret P, Whitworth, Kristin M, Abou Alaiwa, Mahmoud H, Fischer, Anthony J, Warrier, Akshaya, Samuel, Melissa, Spate, Lee D, Allen, Patrick D, Hilkin, Brieanna M, Romano Ibarra, Guillermo S, Ortiz Bezara, Miguel E, Goodell, Brian J, Mather, Steven E, Powers, Linda S, Stroik, Mallory R, Gansemer, Nicholas D, Hippee, Camilla E, Zarei, Keyan, Goeken, J Adam, Businga, Thomas R, Hoffman, Eric A, Meyerholz, David K, Prather, Randall S, Stoltz, David A, Welsh, Michael J
Published in eLife (07.10.2020)
Published in eLife (07.10.2020)
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Abundant DNase I-Sensitive Bacterial DNA in Healthy Porcine Lungs and Its Implications for the Lung Microbiome
PEZZULO, Alejandro A, KELLY, Patrick H, NASSAR, Boulos S, RUTLAND, Cedric J, GANSEMER, Nicholas D, DOHRN, Cassie L, COSTELLO, Andrew J, STOLTZ, David A, ZABNER, Joseph
Published in Applied and Environmental Microbiology (01.10.2013)
Published in Applied and Environmental Microbiology (01.10.2013)
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CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia
Li, Xiaopeng, Comellas, Alejandro P, Karp, Philip H, Ernst, Sarah E, Moninger, Thomas O, Gansemer, Nicholas D, Taft, Peter J, Pezzulo, Alejandro A, Rector, Michael V, Rossen, Nathan, Stoltz, David A, McCray, Jr, Paul B, Welsh, Michael J, Zabner, Joseph
Published in American journal of physiology. Lung cellular and molecular physiology (15.07.2012)
Published in American journal of physiology. Lung cellular and molecular physiology (15.07.2012)
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Reovirus Preferentially Infects the Basolateral Surface and Is Released from the Apical Surface of Polarized Human Respiratory Epithelial Cells
Excoffon, Katherine J. D. A., Guglielmi, Kristen M., Wetzel, J. Denise, Gansemer, Nicholas D., Campbell, Jacquelyn A., Dermody, Terence S., Zabner, Joseph
Published in The Journal of infectious diseases (15.04.2008)
Published in The Journal of infectious diseases (15.04.2008)
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HSP90 inhibitor geldanamycin reverts IL-13- and IL-17-induced airway goblet cell metaplasia
Pezzulo, Alejandro A, Tudas, Rosarie A, Stewart, Carley G, Buonfiglio, Luis G Vargas, Lindsay, Brian D, Taft, Peter J, Gansemer, Nicholas D, Zabner, Joseph
Published in The Journal of clinical investigation (01.02.2019)
Published in The Journal of clinical investigation (01.02.2019)
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Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs
Bae, Hosung, Kim, Bo Ram, Jung, Sunhee, Le, Johnny, van der Heide, Dana, Yu, Wenjie, Park, Sang Hee, Hilkin, Brieanna M., Gansemer, Nicholas D., Powers, Linda S., Kang, Taekyung, Meyerholz, David K., Schuster, Victor L., Jang, Cholsoon, Welsh, Michael J.
Published in The Journal of clinical investigation (01.07.2024)
Published in The Journal of clinical investigation (01.07.2024)
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Mucociliary Clearance is Impaired in Small Airways of Cystic Fibrosis Pigs
Stewart, Carley G, Hilkin, Brieanna M, Gansemer, Nicholas D, Adam, Ryan J, Dick, David W, Sunderland, John J, Stoltz, David A, Zabner, Joseph, Abou Alaiwa, Mahmoud H
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2024)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2024)
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Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs
Pino-Argumedo, Maria I, Fischer, Anthony J, Hilkin, Brieanna M, Gansemer, Nicholas D, Allen, Patrick D, Hoffman, Eric A, Stoltz, David A, Welsh, Michael J, Abou Alaiwa, Mahmoud H
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2022)
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Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells
Kulhankova, Katarina, Cheng, Anna X, Traore, Soumba, Auger, Maud, Pelletier, Mia, Hervault, Maxime, Wells, Kevin D, Green, Jonathan A, Byrne, Addison, Nelson, Benjamin, Sponchiado, Mariana, Boosani, Chandra, Heffner, Caleb S, Snow, Kathy J, Murray, Stephen A, Villacreses, Raul A, Rector, Michael V, Gansemer, Nicholas D, Stoltz, David A, Allamargot, Chantal, Couture, Frédéric, Hemez, Colin, Hallée, Stéphanie, Barbeau, Xavier, Harvey, Mario, Lauvaux, Coraline, Gaillet, Bruno, Newby, Gregory A, Liu, David R, McCray, Jr, Paul B, Guay, David
Published in Nucleic acids research (24.09.2024)
Published in Nucleic acids research (24.09.2024)
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Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility
Cook, Daniel P, Rector, Michael V, Bouzek, Drake C, Michalski, Andrew S, Gansemer, Nicholas D, Reznikov, Leah R, Li, Xiaopeng, Stroik, Mallory R, Ostedgaard, Lynda S, Abou Alaiwa, Mahmoud H, Thompson, Michael A, Prakash, Y S, Krishnan, Ramaswamy, Meyerholz, David K, Seow, Chun Y, Stoltz, David A
Published in American journal of respiratory and critical care medicine (15.02.2016)
Published in American journal of respiratory and critical care medicine (15.02.2016)
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Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs
Stoltz, David A, Rokhlina, Tatiana, Ernst, Sarah E, Pezzulo, Alejandro A, Ostedgaard, Lynda S, Karp, Philip H, Samuel, Melissa S, Reznikov, Leah R, Rector, Michael V, Gansemer, Nicholas D, Bouzek, Drake C, Abou Alaiwa, Mahmoud H, Hoegger, Mark J, Ludwig, Paula S, Taft, Peter J, Wallen, Tanner J, Wohlford-Lenane, Christine, McMenimen, James D, Chen, Jeng-Haur, Bogan, Katrina L, Adam, Ryan J, Hornick, Emma E, Nelson, 4th, George A, Hoffman, Eric A, Chang, Eugene H, Zabner, Joseph, McCray, Jr, Paul B, Prather, Randall S, Meyerholz, David K, Welsh, Michael J
Published in The Journal of clinical investigation (01.06.2013)
Published in The Journal of clinical investigation (01.06.2013)
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Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets
ADAM, Ryan J, MICHALSKI, Andrew S, DIWAKAR, Amit, OCHS, Matthias, REINHARDT, Joseph M, HOFFMAN, Eric A, BEICHEL, Reinhard R, MEYERHOLZ, David K, STOLTZ, David A, BAUER, Christian, ABOU ALAIWA, Mahmoud H, CROSS, Thomas J, AWADALLA, Maged S, BOUZEK, Drake C, GANSEMER, Nicholas D, TAFT, Peter J, HOEGGER, Mark J
Published in American journal of respiratory and critical care medicine (15.12.2013)
Published in American journal of respiratory and critical care medicine (15.12.2013)
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Il-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption
Romano Ibarra, Guillermo S, Lei, Lei, Yu, Wenjie, Thurman, Andrew L, Gansemer, Nicholas D, Meyerholz, David K, Pezzulo, Alejandro A, McCray, Paul B, Thornell, Ian M, Stoltz, David A
Published in The Journal of clinical investigation (10.09.2024)
Published in The Journal of clinical investigation (10.09.2024)
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Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis
Chang, Eugene H., Pezzulo, Alejandro A., Meyerholz, David K., Potash, Andrea E., Wallen, Tanner J., Reznikov, Leah R., Sieren, Jessica C., Karp, Philip H., Ernst, Sarah, Moninger, Thomas O., Gansemer, Nicholas D., McCray, Paul B., Stoltz, David A., Welsh, Michael J., Zabner, Joseph
Published in The Laryngoscope (01.09.2012)
Published in The Laryngoscope (01.09.2012)
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CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes
Steines, Benjamin, Dickey, David D, Bergen, Jamie, Excoffon, Katherine Jda, Weinstein, John R, Li, Xiaopeng, Yan, Ziying, Abou Alaiwa, Mahmoud H, Shah, Viral S, Bouzek, Drake C, Powers, Linda S, Gansemer, Nicholas D, Ostedgaard, Lynda S, Engelhardt, John F, Stoltz, David A, Welsh, Michael J, Sinn, Patrick L, Schaffer, David V, Zabner, Joseph
Published in JCI insight (08.09.2016)
Published in JCI insight (08.09.2016)
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Postnatal airway growth in cystic fibrosis piglets
Adam, Ryan J, Abou Alaiwa, Mahmoud H, Bouzek, Drake C, Cook, Daniel P, Gansemer, Nicholas D, Taft, Peter J, Powers, Linda S, Stroik, Mallory R, Hoegger, Mark J, McMenimen, James D, Hoffman, Eric A, Zabner, Joseph, Welsh, Michael J, Meyerholz, David K, Stoltz, David A
Published in Journal of applied physiology (1985) (01.09.2017)
Published in Journal of applied physiology (1985) (01.09.2017)
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