In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
Hostetler, Eric D, Joshi, Aniket D, Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O'Malley, Stacey, Miller, Patricia, Selnick, Harold G, Gallicchio, Steven N, Bell, Ian M, Salvatore, Christopher A, Kane, Stefanie A, Li, Chi-Chung, Hargreaves, Richard J, de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W P, Blanchard, Rebecca, Marcantonio, Eugene E, Sur, Cyrille, Cook, Jacquelynn J, Van Laere, Koen, Evelhoch, Jeffrey L
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
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Journal Article
Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists
Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
Beshore, Douglas C., Adam, Gregory C., Barnard, Richard J. O., Burlein, Christine, Gallicchio, Steven N., Holloway, M. Katharine, Krosky, Daniel, Lemaire, Wei, Myers, Robert W., Patel, Sangita, Plotkin, Michael A., Powell, David A., Rada, Vanessa, Cox, Christopher D., Coleman, Paul J., Klein, Daniel J., Wolkenberg, Scott E.
Published in ACS medicinal chemistry letters (08.04.2021)
Published in ACS medicinal chemistry letters (08.04.2021)
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Journal Article
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist
Salvatore, Christopher A, Moore, Eric L, Calamari, Amy, Cook, Jacquelynn J, Michener, Maria S, O'Malley, Stacey, Miller, Patricia J, Sur, Cyrille, Williams, Jr, David L, Zeng, Zhizhen, Danziger, Andrew, Lynch, Joseph J, Regan, Christopher P, Fay, John F, Tang, Yui S, Li, Chi-Chung, Pudvah, Nicole T, White, Rebecca B, Bell, Ian M, Gallicchio, Steven N, Graham, Samuel L, Selnick, Harold G, Vacca, Joseph P, Kane, Stefanie A
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
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Journal Article
MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
Bell, Ian M., Stump, Craig A., Gallicchio, Steven N., Staas, Donnette D., Zartman, C. Blair, Moore, Eric L., Sain, Nova, Urban, Mark, Bruno, Joseph G., Calamari, Amy, Kemmerer, Amanda L., Mosser, Scott D., Fandozzi, Christine, White, Rebecca B., Zrada, Matthew M., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P., Kane, Stefanie A., Salvatore, Christopher A.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article
Identification of a novel RAMP-independent CGRP receptor antagonist
Zartman, C. Blair, Bell, Ian M., Gallicchio, Steven N., Graham, Samuel L., Kane, Stefanie A., Mallee, John J., Rutledge, Ruth Z., Salvatore, Christopher A., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist
Bell, Ian M, Gallicchio, Steven N, Wood, Michael R, Quigley, Amy G, Stump, Craig A, Zartman, C. Blair, Fay, John F, Li, Chi-Chung, Lynch, Joseph J, Moore, Eric L, Mosser, Scott D, Prueksaritanont, Thomayant, Regan, Christopher P, Roller, Shane, Salvatore, Christopher A, Kane, Stefanie A, Vacca, Joseph P, Selnick, Harold G
Published in ACS medicinal chemistry letters (08.04.2010)
Published in ACS medicinal chemistry letters (08.04.2010)
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Journal Article
The discovery of highly potent CGRP receptor antagonists
Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Bruno, Joseph G., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Salvatore, Christopher A., Theberge, Cory R., Blair Zartman, C., Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
[11C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor
Bell, Ian M, Gallicchio, Steven N, Stump, Craig A, Bruno, Joseph G, Fan, Hong, Gantert, Liza T, Hostetler, Eric D, Kemmerer, Amanda L, McWherter, Melody, Moore, Eric L, Mosser, Scott D, Purcell, Mona L, Riffel, Kerry, Salvatore, Christopher A, Sanabria-Bohórquez, Sandra, Staas, Donnette D, White, Rebecca B, Williams, Mangay, Zartman, C. Blair, Cook, Jacquelynn J, Hargreaves, Richard J, Kane, Stefanie A, Graham, Samuel L, Selnick, Harold G
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
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Journal Article
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead
Williams, Theresa M., Stump, Craig A., Nguyen, Diem N., Quigley, Amy G., Bell, Ian M., Gallicchio, Steven N., Zartman, C. Blair, Wan, Bang-Lin, Penna, Kimberly Della, Kunapuli, Priya, Kane, Stefanie A., Koblan, Ken S., Mosser, Scott D., Rutledge, Ruth Z., Salvatore, Christopher, Fay, John F., Vacca, Joseph P., Graham, Samuel L.
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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Journal Article
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hochman, Jerome H., McMasters, Daniel R., Miller-Stein, Cynthia, Moore, Eric L., Mosser, Scott D., Pudvah, Nicole T., Quigley, Amy G., Salvatore, Christopher A., Stump, Craig A., Theberge, Cory R., Wong, Bradley K., Zartman, C. Blair, Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
Identification of potent, highly constrained CGRP receptor antagonists
Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hershey, James C., Jelley, Richard, Kreatsoulas, Constantine, Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Roller, Shane A., Salvatore, Christopher A., Sharik, Steven S., Theberge, Cory R., Zartman, C. Blair, Kane, Stefanie A., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Journal Article
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases
Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair
Published in Biochemistry (Easton) (12.07.2005)
Published in Biochemistry (Easton) (12.07.2005)
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Journal Article
Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones
Bell, Ian M, Beshore, Douglas C, Gallicchio, Steven N, Williams, Theresa M
Published in Tetrahedron letters (19.02.2000)
Published in Tetrahedron letters (19.02.2000)
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Journal Article
Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines
Bell, Ian M, Erb, Jill M, Freidinger, Roger M, Gallicchio, Steven N, Guare, James P, Guidotti, Maribeth T, Halpin, Rita A, Hobbs, Doug W, Homnick, Carl F, Kuo, Michelle S, Lis, Edward V, Mathre, David J, Michelson, Stuart R, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R, Vickers, Stanley, Williams, Peter D, Woyden, Carla J
Published in Journal of medicinal chemistry (04.06.1998)
Published in Journal of medicinal chemistry (04.06.1998)
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Journal Article
PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
BELL IAN M, FRALEY MARK E, MITCHELL HELEN J, GINNETTI ANTHONY, WANG CHENG, PAONE DANIEL V, STAAS DONNETTE D, STEVENSON HEATHER E, GALLICCHIO STEVEN N, ZARTMAN C. BLAIR
Year of Publication 05.08.2013
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Year of Publication 05.08.2013
Patent
3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency
Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beese, Lorena S, Beshore, Douglas C, Bhimnathwala, Hema, Bogusky, Michael J, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hamilton, Kelly A, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huber, Hans E, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Robinson, Ronald, Rodrigues, A. David, Taylor, Jeffrey S, Walsh, Eileen S, Williams, Theresa M, Zartman, C. Blair
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Journal Article
Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency
Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M
Published in Journal of medicinal chemistry (30.08.2001)
Published in Journal of medicinal chemistry (30.08.2001)
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