Oral tyrosine kinase 2 inhibitor PF-06826647 demonstrates efficacy and an acceptable safety profile in participants with moderate-to-severe plaque psoriasis in a phase 2b, randomized, double-blind, placebo-controlled study
Tehlirian, Christopher, Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Tarabar, Sanela, Peeva, Elena, Vincent, Michael S., Gale, Jeremy D.
Published in Journal of the American Academy of Dermatology (01.08.2022)
Published in Journal of the American Academy of Dermatology (01.08.2022)
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Journal Article
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study
Sandborn, William J., Danese, Silvio, Leszczyszyn, Jaroslaw, Romatowski, Jacek, Altintas, Engin, Peeva, Elena, Hassan-Zahraee, Mina, Vincent, Michael S., Reddy, Padmalatha S., Banfield, Christopher, Salganik, Mikhail, Banerjee, Anindita, Gale, Jeremy D., Hung, Kenneth E.
Published in Clinical gastroenterology and hepatology (01.09.2023)
Published in Clinical gastroenterology and hepatology (01.09.2023)
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A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema
Gale, Jeremy D, Berger, Brian, Gilbert, Steven, Popa, Serghei, Sultan, Marla B, Schachar, Ronald A, Girgenti, Douglas, Perros-Huguet, Christelle
Published in Investigative ophthalmology & visual science (01.05.2018)
Published in Investigative ophthalmology & visual science (01.05.2018)
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Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open-Label, Phase 1 Study
Martin, David A, Telliez, Jean-Baptiste, Pleasic-Williams, Susan, Zhang, Ying, Tierney, Brendan, Blatnik, Matthew, Gale, Jeremy D, Banfield, Chris, Zhou, Yifan, Lejeune, Alexandre, Zwillich, Samuel H, Stevens, Erin, Tiwari, Neeraj, Kieras, Elizabeth, Karanam, Ashwin
Published in Journal of clinical pharmacology (01.01.2024)
Published in Journal of clinical pharmacology (01.01.2024)
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Baseline Serum and Stool Microbiome Biomarkers Predict Clinical Efficacy and Tissue Molecular Response After Ritlecitinib Induction Therapy in Ulcerative Colitis
Hassan-Zahraee, Mina, Ye, Zhan, Xi, Li, Dushin, Elizabeth, Lee, Julie, Romatowski, Jacek, Leszczyszyn, Jaroslaw, Danese, Silvio, Sandborn, William J, Banfield, Christopher, Gale, Jeremy D, Peeva, Elena, Longman, Randy S, Hyde, Craig L, Hung, Kenneth E
Published in Journal of Crohn's and colitis (03.09.2024)
Published in Journal of Crohn's and colitis (03.09.2024)
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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study
Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Scaramozza, Matthew, Kieras, Elizabeth, Gale, Jeremy D., Peeva, Elena, Vincent, Michael S., Banerjee, Anindita, Fensome, Andrew, Dowty, Martin E., Winkle, Peter, Tehlirian, Christopher
Published in Clinical and translational science (01.03.2021)
Published in Clinical and translational science (01.03.2021)
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Biomarkers of Crohn’s Disease to Support the Development of New Therapeutic Interventions
Porter, Amy C, Aubrecht, Jiri, Birch, Chandler, Braun, Jonathan, Cuff, Carolyn, Dasgupta, Suryasarathi, Gale, Jeremy D, Hinton, Robert, Hoffmann, Steven C, Honig, Gerard, Linggi, Bryan, Schito, Marco, Casteele, Niels Vande, Sauer, John-Michael
Published in Inflammatory bowel diseases (01.10.2020)
Published in Inflammatory bowel diseases (01.10.2020)
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Advantages of a wholly Bayesian approach to assessing efficacy in early drug development: a case study
Walley, Rosalind J., Smith, Claire L., Gale, Jeremy D., Woodward, Phil
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.05.2015)
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.05.2015)
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Histological sub‐classification of cirrhosis using collagen proportionate area in patients with chronic hepatitis C
Papatheodoridi, Margarita, Hall, Andrew R., Rodríguez‐Perálvarez, Manuel, Pieri, Giulia, Germani, Giacomo, Gale, Jeremy D., Burgess, Gary C., Pinzani, Massimo, Dhillon, Amar P., Tsochatzis, Emmanuel A.
Published in Liver international (01.07.2021)
Published in Liver international (01.07.2021)
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Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors
Rosin, Diane L, Hall, J Perry, Zheng, Shuqiu, Huang, Liping, Campos-Bilderback, Silvia, Sandoval, Ruben, Bree, Andrea, Beaumont, Kevin, Miller, Emily, Larsen, Jennifer, Hariri, Ghazal, Kaila, Neelu, Encarnacion, Iain M, Gale, Jeremy D, van Elsas, Andrea, Molitoris, Bruce A, Okusa, Mark D
Published in Frontiers in medicine (28.07.2022)
Published in Frontiers in medicine (28.07.2022)
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Journal Article
Safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of the oral TYK2 inhibitor PF-06826647 in participants with plaque psoriasis: a phase 1, randomised, double-blind, placebo-controlled, parallel-group study
Tehlirian, Christopher, Peeva, Elena, Kieras, Elizabeth, Scaramozza, Matthew, Roberts, Erika S, Singh, Ravi Shankar P, Pradhan, Vivek, Banerjee, Anindita, Garcet, Sandra, Xi, Li, Gale, Jeremy D, Vincent, Michael S, Krueger, James
Published in The Lancet. Rheumatology (01.03.2021)
Published in The Lancet. Rheumatology (01.03.2021)
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Journal Article
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy
Gale, Jeremy D, Gilbert, Steven, Blumenthal, Samuel, Elliott, Tom, Pergola, Pablo E, Goteti, Kosalaram, Scheele, Wim, Perros-Huguet, Christelle
Published in Kidney international reports (01.11.2018)
Published in Kidney international reports (01.11.2018)
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Journal Article
A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring
Gale, Jeremy D, Jensen, Jeff, Berman, Gabe, Freimuth, William, Li, Gang, Pleil, Andreas, Kutty, Malik, Rosenthal, Andrew, Boswell, C.B, Noah, V., E Magnus, Young, Leroy
Published in Plastic and reconstructive surgery. Global open (01.09.2018)
Published in Plastic and reconstructive surgery. Global open (01.09.2018)
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Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat
Ferens, Dorota M, Yin, Lei, Ohashi-Doi, Katsuyo, Habgood, Mark, Bron, Romke, Brock, James A, Gale, Jeremy D, Furness, John B
Published in Clinical and experimental pharmacology & physiology (01.09.2010)
Published in Clinical and experimental pharmacology & physiology (01.09.2010)
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Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene
Banner, Katharine H, Cattaneo, Christophe, Net, Jean‐Loic Le, Popovic, Aleksandar, Collins, David, Gale, Jeremy D
Published in British journal of pharmacology (01.11.2004)
Published in British journal of pharmacology (01.11.2004)
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