Discovery and Preclinical Characterization of 3‑((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications
Galambos, János, Bielik, Attila, Krasavin, Mikhail, Orgován, Zoltán, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Balogh, György T, Béni, Zoltán, Kóti, János, Szakács, Zoltán, Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L, Vastag, Mónika, Sághy, Katalin, Laszy, Judit, Halász, Attila Sándor, Balázs, Ottilia, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators
Galambos, János, Bielik, Attila, Wágner, Gábor, Domány, György, Kóti, János, Béni, Zoltán, Szigetvári, Áron, Sánta, Zsuzsanna, Orgován, Zoltán, Bobok, Amrita, Kiss, Béla, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Krasavin, Mikhail, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M.
Published in European journal of medicinal chemistry (16.06.2017)
Published in European journal of medicinal chemistry (16.06.2017)
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4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate
Galambos, János, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Keserű, György M., Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Kóti, János, Szakács, Zoltán, Béni, Zoltán, Gál, Krisztina, Szombathelyi, Zsolt, Greiner, István
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization
Nogradi, Katalin, Wagner, Gabor, Domany, Gyorgy, Bobok, Amrita, Magdo, Ildiko, Kolok, Sandor, Miko-Bakk, Monika L., Vastag, Monika, Saghy, Katalin, Gyertyan, Istvan, Koti, Janos, Gal, Krisztina, Farkas, Sandor, Keseru, Gyorgy M., Greiner, Istvan, Szombathelyi, Zsolt
Published in Bioorganic & medicinal chemistry letters (15.04.2015)
Published in Bioorganic & medicinal chemistry letters (15.04.2015)
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Mobile Health Technology for the Personalized Therapy of Hemophilia
Dirzu, Noemi, Hotea, Ionut, Jitaru, Ciprian, Brinza, Melen, Urian, Laura, Peters, Mareike-Catrina, Gal, Krisztina, Popescu, Louis, Blag, Cristina, Marian, Mirela, Pal, Eva, Stanescu, Marilena, Cenariu, Diana, Tarniceriu, Cristina, Serban, Margit, Dima, Delia, Coriu, Daniel, Tomuleasa, Ciprian
Published in Frontiers in medicine (10.08.2021)
Published in Frontiers in medicine (10.08.2021)
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Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Hit-to-lead optimization
Nógrádi, Katalin, Wágner, Gábor, Domány, György, Bobok, Amrita, Magdó, Ildikó, Kiss, Béla, Kolok, Sándor, Fónagy, Katalin, Gyertyán, István, Háda, Viktor, Kóti, János, Gál, Krisztina, Farkas, Sándor, Keserű, György M., Greiner, István, Szombathelyi, Zsolt
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Effect of cigarette smoke and dexamethasone on Hsp72 system of alveolar epithelial cells
Gál, Krisztina, Cseh, Áron, Szalay, Balázs, Rusai, Krisztina, Vannay, Ádám, Lukácsovits, József, Heemann, Uwe, Szabó, Attila J., Losonczy, György, Tamási, Lilla, Müller, Veronika
Published in Cell stress & chaperones (01.07.2011)
Published in Cell stress & chaperones (01.07.2011)
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Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs
Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Increased Heat Shock Protein 72 Expression in Celiac Disease
Sziksz, Erna, Veres, Gábor, Vannay, Ádám, Prókai, Ágnes, Gál, Krisztina, Ónody, Anna, Korponay‐Szabó, Ilma Rita, Reusz, György, Szabó, András, Tulassay, Tivadar, Arató, András, Szebeni, Beáta
Published in Journal of pediatric gastroenterology and nutrition (01.11.2010)
Published in Journal of pediatric gastroenterology and nutrition (01.11.2010)
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Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, János, Wágner, Gábor, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Gyertyán, István, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Effects of RGH-237 [ N -{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D 3 Receptor Partial Agonist in Animal Models of Cocaine Abuse
Gyertyán, István, Kiss, Béla, Gál, Krisztina, Laszlovszky, István, Horváth, Attila, Gémesi, Larisza I., Sághy, Katalin, Pásztor, Gabriella, Zájer, Mária, Kapás, Margit, Csongor, Éva Ágai, Domány, György, Tihanyi, Károly, Szombathelyi, Zsolt
Published in The Journal of pharmacology and experimental therapeutics (01.03.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2007)
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Tumor Cell Expression of Heat Shock Protein (HSP) 72 is Influenced by HSP72 [HSPA1B A(1267)G] Polymorphism and Predicts Survival in Small Cell Lung Cancer (SCLC) Patients
Szondy, Klara, Rusai, Krisztina, Szabó, Attila J., Nagy, Andrea, Gal, Krisztina, Fekete, Andrea, Kovats, Zsuzsanna, Losonczy, Gyorgy, Lukacsovits, József, Müller, Veronika
Published in Cancer investigation (01.05.2012)
Published in Cancer investigation (01.05.2012)
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Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluRS NAMs
WAGNER, Gábor, WEBER, Csaba, NAGY, József, KURKO, Dalma, GAL, Krisztina, GREINER, István, SZOMBATHELYI, Zsolt, KESERU, György M, DOMANY, György, NYEKI, Olga, NOGRADI, Katalin, BIELIK, Attila, MOLNAR, László, BOBOK, Amrita, HORVATH, Attila, KISS, Béla, KOLOK, Sándor
Published in Bioorganic & medicinal chemistry letters (2010)
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Published in Bioorganic & medicinal chemistry letters (2010)
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Corrigendum to “Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs” [Bioorg. Med. Chem. Lett. 20 (2010) 3737–3741]
Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Effects of RGH-237 [N-{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D3 Receptor Partial Agonist in Animal Models of Cocaine Abuse
István Gyertyán, Béla Kiss, Krisztina Gál, István Laszlovszky, Attila Horváth, Larisza I. Gémesi, Katalin Sághy, Gabriella Pásztor, Mária Zájer, Margit Kapás, Ãva Ãgai Csongor, György Domány, Károly Tihanyi, Zsolt Szombathelyi
Published in The Journal of pharmacology and experimental therapeutics (01.03.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2007)
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