Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition
Gajiwala, Ketan S., Feng, Junli, Ferre, RoseAnn, Ryan, Kevin, Brodsky, Oleg, Weinrich, Scott, Kath, John C., Stewart, Al
Published in Structure (London) (05.02.2013)
Published in Structure (London) (05.02.2013)
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Journal Article
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Published in Nature communications (28.04.2016)
Published in Nature communications (28.04.2016)
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Journal Article
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors
Niessen, Sherry, Dix, Melissa M., Barbas, Sabrina, Potter, Zachary E., Lu, Shuyan, Brodsky, Oleg, Planken, Simon, Behenna, Douglas, Almaden, Chau, Gajiwala, Ketan S., Ryan, Kevin, Ferre, RoseAnn, Lazear, Michael R., Hayward, Matthew M., Kath, John C., Cravatt, Benjamin F.
Published in Cell chemical biology (16.11.2017)
Published in Cell chemical biology (16.11.2017)
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Journal Article
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Published in eLife (29.11.2017)
Published in eLife (29.11.2017)
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Journal Article
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
Gajiwala, Ketan S, Wu, Joe C, Christensen, James, Deshmukh, Gayatri D, Diehl, Wade, DiNitto, Jonathan P, English, Jessie M, Greig, Michael J, He, You-Ai, Jacques, Suzanne L, Lunney, Elizabeth A, McTigue, Michele, Molina, David, Quenzer, Terri, Wells, Peter A, Yu, Xiu, Zhang, Yan, Zou, Aihua, Emmett, Mark R, Marshall, Alan G, Zhang, Hui-Min, Demetri, George D
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.2009)
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Journal Article
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
Qiu, Luping, Levine, Kymberly, Gajiwala, Ketan S, Cronin, Ciarán N, Nagata, Asako, Johnson, Eric, Kraus, Michelle, Tatlock, John, Kania, Robert, Foley, Timothy, Sun, Shaoxian
Published in PloS one (07.06.2018)
Published in PloS one (07.06.2018)
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Journal Article
Ack1: activation and regulation by allostery
Gajiwala, Ketan S, Maegley, Karen, Ferre, RoseAnn, He, You-Ai, Yu, Xiu
Published in PloS one (14.01.2013)
Published in PloS one (14.01.2013)
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Journal Article
Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme
Gajiwala, Ketan S., Margosiak, Stephen, Lu, Jia, Cortez, Joseph, Su, Ying, Nie, Zhe, Appelt, Krzysztof
Published in FEBS letters (03.09.2009)
Published in FEBS letters (03.09.2009)
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Journal Article
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes
Zhao, Qian, Ouyang, Xiaohu, Wan, Xiaobo, Gajiwala, Ketan S, Kath, John C, Jones, Lyn H, Burlingame, Alma L, Taunton, Jack
Published in Journal of the American Chemical Society (18.01.2017)
Published in Journal of the American Chemical Society (18.01.2017)
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Journal Article
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Li, Di, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Journal Article
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
Gajiwala, Ketan S, Chen, Hua, Cornille, Fabrice, Roques, Bernard P, Reith, Walter, Mach, Bernard, Burley, Stephen K
Published in Nature (London) (24.02.2000)
Published in Nature (London) (24.02.2000)
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Journal Article
Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry
Zhang, Hui‐Min, Yu, Xiu, Greig, Michael J., Gajiwala, Ketan S., Wu, Joe C., Diehl, Wade, Lunney, Elizabeth A., Emmett, Mark R., Marshall, Alan G.
Published in Protein science (01.04.2010)
Published in Protein science (01.04.2010)
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Journal Article
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1
Ryan, Kevin, Bolaňos, Ben, Smith, Marissa, Palde, Prakash B., Cuenca, Paulina Delgado, VanArsdale, Todd L., Niessen, Sherry, Zhang, Lianglin, Behenna, Douglas, Ornelas, Martha A., Tran, Khanh T., Kaiser, Stephen, Lum, Lawrence, Stewart, Al, Gajiwala, Ketan S.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael, Deng, Ya-Li, Dinh, Dac, Fan, Connie, Gajiwala, Ketan S., Grantner, Rita, Gukasyan, Hovhannes J., Hu, Wenyue, Huang, Buwen, Kania, Robert, Kephart, Susan E., Krivacic, Cody, Kumpf, Robert A., Khamphavong, Penney, Kraus, Manfred, Liu, Wei, Maegley, Karen A., Nguyen, Lisa, Ren, Shijian, Richter, Dan, Rollins, Robert A., Sach, Neal, Sharma, Shikhar, Sherrill, John, Spangler, Jillian, Stewart, Albert E., Sutton, Scott, Uryu, Sean, Verhelle, Dominique, Wang, Hui, Wang, Shuiwang, Wythes, Martin, Xin, Shuibo, Yamazaki, Shinji, Zhu, Huichun, Zhu, JinJiang, Zehnder, Luke, Edwards, Martin
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase
Gajiwala, Ketan S., Grodsky, Neil, Bolaños, Ben, Feng, Junli, Ferre, RoseAnn, Timofeevski, Sergei, Xu, Meirong, Murray, Brion W., Johnson, Ted W., Stewart, Al
Published in The Journal of biological chemistry (22.09.2017)
Published in The Journal of biological chemistry (22.09.2017)
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Journal Article
Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Journal Article
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Di, Li, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Journal Article