Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation
Fernández-Nogueira, Patricia, Mancino, Mario, Fuster, Gemma, López-Plana, Anna, Jauregui, Patricia, Almendro, Vanesa, Enreig, Estel, Menéndez, Silvia, Rojo, Federico, Noguera-Castells, Aleix, Bill, Anke, Gaither, L Alex, Serrano, Laia, Recalde-Percaz, Leire, Moragas, Núria, Alonso, Raul, Ametller, Elisabet, Rovira, Ana, Lluch, Ana, Albanell, Joan, Gascon, Pere, Bragado, Paloma
Published in Clinical cancer research (15.03.2020)
Published in Clinical cancer research (15.03.2020)
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FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor
Guagnano, Vito, Kauffmann, Audrey, Wöhrle, Simon, Stamm, Christelle, Ito, Moriko, Barys, Louise, Pornon, Astrid, Yao, Yao, Li, Fang, Zhang, Yun, Chen, Zhi, Wilson, Christopher J, Bordas, Vincent, Le Douget, Mickaël, Gaither, L Alex, Borawski, Jason, Monahan, John E, Venkatesan, Kavitha, Brümmendorf, Thomas, Thomas, David M, Garcia-Echeverria, Carlos, Hofmann, Francesco, Sellers, William R, Graus-Porta, Diana
Published in Cancer discovery (01.12.2012)
Published in Cancer discovery (01.12.2012)
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ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer
Bill, Anke, Gutierrez, Abraham, Kulkarni, Sucheta, Kemp, Carolyn, Bonenfant, Debora, Voshol, Hans, Duvvuri, Umamaheswar, Gaither, L Alex
Published in Oncotarget (20.04.2015)
Published in Oncotarget (20.04.2015)
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Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
Britschgi, Adrian, Bill, Anke, Brinkhaus, Heike, Rothwell, Christopher, Clay, Ieuan, Duss, Stephan, Rebhan, Michael, Raman, Pichai, Guy, Chantale T, Wetzel, Kristie, George, Elizabeth, Popa, M Oana, Lilley, Sarah, Choudhury, Hedaythul, Gosling, Martin, Wang, Louis, Fitzgerald, Stephanie, Borawski, Jason, Baffoe, Jonathan, Labow, Mark, Gaither, L Alex, Bentires-Alj, Mohamed
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
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Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer
O'Brien, Neil A, McDermott, Martina S J, Conklin, Dylan, Luo, Tong, Ayala, Raul, Salgar, Suruchi, Chau, Kevin, DiTomaso, Emmanuelle, Babbar, Naveen, Su, Faye, Gaither, Alex, Hurvitz, Sara A, Linnartz, Ronald, Rose, Kristine, Hirawat, Samit, Slamon, Dennis J
Published in Breast cancer research : BCR (14.08.2020)
Published in Breast cancer research : BCR (14.08.2020)
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CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases
Leroy, C, Shen, Q, Strande, V, Meyer, R, McLaughlin, M E, Lezan, E, Bentires-Alj, M, Voshol, H, Bonenfant, D, Alex Gaither, L
Published in Oncogene (29.10.2015)
Published in Oncogene (29.10.2015)
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To Grow or Go: TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
SHIWARSKI, Daniel J, CHUNBO SHAO, GRANDIS, Jennifer, GAITHER, L. Alex, PUTHENVEEDU, Manojkumar A, DUVVURI, Umamaheswar, BILL, Anke, KIM, Jean, DONG XIAO, BERTRAND, Carol A, SEETHALA, Raja S, SANO, Daisuke, MYERS, Jeffery N, HA, Patrick
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication
BORAWSKI, Jason, TROKE, Philip, BARYZA, Jeremy, TALLARICO, John, JOBERTY, Gerard, BANTSCHEFF, Marcus, SCHIRLE, Markus, BOUWMEESTER, Tewis, MATHY, Joanna E, KAI LIN, COMPTON, Teresa, LABOW, Mark, XIAOLING PUYANG, WIEDMANN, Brigitte, GAITHER, L. Alex, GIBAJA, Veronica, SHANCHAUN ZHAO, MICKANIN, Craig, LEIGHTON-DAVIES, Juliet, WILSON, Christopher J, MYER, Vic, CORNELLATARACIDO, Ivan
Published in Journal of Virology (01.10.2009)
Published in Journal of Virology (01.10.2009)
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TMEM16A/ANO1 suppression improves response to antibody‐mediated targeted therapy of EGFR and HER2/ERBB2
Kulkarni, Sucheta, Bill, Anke, Godse, Neal R., Khan, Nayel I., Kass, Jason I., Steehler, Kevin, Kemp, Carolyn, Davis, Kara, Bertrand, Carol A., Vyas, Avani R., Holt, Douglas E., Grandis, Jennifer R., Gaither, L Alex, Duvvuri, Umamaheswar
Published in Genes chromosomes & cancer (01.06.2017)
Published in Genes chromosomes & cancer (01.06.2017)
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Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers
Hoover, Heather, Li, Jun, Marchese, Jason, Rothwell, Christopher, Borawoski, Jason, Jeffery, Douglas A, Gaither, L. Alex, Finkel, Nancy
Published in Journal of proteome research (04.09.2015)
Published in Journal of proteome research (04.09.2015)
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MK-STYX, a Catalytically Inactive Phosphatase Regulating Mitochondrially Dependent Apoptosis
Niemi, Natalie M., Lanning, Nathan J., Klomp, Jeff A., Tait, Stephen W., Xu, Yong, Dykema, Karl J., Murphy, Leon O., Gaither, L. Alex, Xu, H. Eric, Furge, Kyle A., Green, Douglas R., MacKeigan, Jeffrey P.
Published in Molecular and Cellular Biology (01.04.2011)
Published in Molecular and Cellular Biology (01.04.2011)
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The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1
Niemi, Natalie M, Sacoman, Juliana L, Westrate, Laura M, Gaither, L Alex, Lanning, Nathan J, Martin, Katie R, MacKeigan, Jeffrey P
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Multiple cyclophilins involved in different cellular pathways mediate HCV replication
Gaither, L. Alex, Borawski, Jason, Anderson, Leah J, Balabanis, Kara A, Devay, Piroska, Joberty, Gerard, Rau, Christina, Schirle, Markus, Bouwmeester, Tewis, Mickanin, Craig, Zhao, ShanChuan, Vickers, Chad, Lee, Lac, Deng, Gejing, Baryza, Jeremy, Fujimoto, Roger A, Lin, Kai, Compton, Teresa, Wiedmann, Brigitte
Published in Virology (New York, N.Y.) (05.02.2010)
Published in Virology (New York, N.Y.) (05.02.2010)
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High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function
Bill, Anke, Rosethorne, Elizabeth M, Kent, Toby C, Fawcett, Lindsay, Burchell, Lynn, van Diepen, Michiel T, Marelli, Anthony, Batalov, Sergey, Miraglia, Loren, Orth, Anthony P, Renaud, Nicole A, Charlton, Steven J, Gosling, Martin, Gaither, L Alex, Groot-Kormelink, Paul J
Published in PloS one (02.06.2014)
Published in PloS one (02.06.2014)
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Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death
Elis, Winfried, Triantafellow, Ellen, Wolters, Natalie M, Sian, Katie R, Caponigro, Giordano, Borawski, Jason, Gaither, L Alex, Murphy, Leon O, Finan, Peter M, Mackeigan, Jeffrey P
Published in Molecular cancer research (01.04.2008)
Published in Molecular cancer research (01.04.2008)
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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
Tria, George S, Abrams, Tinya, Baird, Jason, Burks, Heather E, Firestone, Brant, Gaither, L. Alex, Hamann, Lawrence G, He, Guo, Kirby, Christina A, Kim, Sunkyu, Lombardo, Franco, Macchi, Kaitlin J, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Springer, Clayton, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Yu, Bing, Tiong-Yip, Choi-Lai, Peukert, Stefan
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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