JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Schwartz, Daniella M, Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J
Published in Nature reviews. Drug discovery (01.12.2017)
Published in Nature reviews. Drug discovery (01.12.2017)
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Journal Article
Type 2 immunity in the skin and lungs
Akdis, Cezmi A., Arkwright, Peter D., Brüggen, Marie-Charlotte, Busse, William, Gadina, Massimo, Guttman‐Yassky, Emma, Kabashima, Kenji, Mitamura, Yasutaka, Vian, Laura, Wu, Jianni, Palomares, Oscar
Published in Allergy (Copenhagen) (01.07.2020)
Published in Allergy (Copenhagen) (01.07.2020)
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Journal Article
The JAK-STAT pathway at 30: Much learned, much more to do
Philips, Rachael L., Wang, Yuxin, Cheon, HyeonJoo, Kanno, Yuka, Gadina, Massimo, Sartorelli, Vittorio, Horvath, Curt M., Darnell, James E., Stark, George R., O’Shea, John J.
Published in Cell (13.10.2022)
Published in Cell (13.10.2022)
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Journal Article
JAK inhibitors: Ten years after
Spinelli, Francesca Romana, Meylan, Françoise, O'Shea, John J., Gadina, Massimo
Published in European journal of immunology (01.07.2021)
Published in European journal of immunology (01.07.2021)
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Journal Article
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention
O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian
Published in Annual review of medicine (01.01.2015)
Published in Annual review of medicine (01.01.2015)
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Journal Article
Janus kinases to jakinibs: from basic insights to clinical practice
Gadina, Massimo, Le, Mimi T, Schwartz, Daniella M, Silvennoinen, Olli, Nakayamada, Shingo, Yamaoka, Kunihiro, O'Shea, John J
Published in Rheumatology (Oxford, England) (01.02.2019)
Published in Rheumatology (Oxford, England) (01.02.2019)
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Journal Article
Translational and clinical advances in JAK‐STAT biology: The present and future of jakinibs
Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.
Published in Journal of leukocyte biology (01.09.2018)
Published in Journal of leukocyte biology (01.09.2018)
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Journal Article
Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction
Furumoto, Yasuko, Smith, Carolyne K., Blanco, Luz, Zhao, Wenpu, Brooks, Stephen R., Thacker, Seth G., Zarzour, Abdalrahman, Sciumè, Giuseppe, Tsai, Wanxia L., Trier, Anna M., Nunez, Leti, Mast, Laurel, Hoffmann, Victoria, Remaley, Alan T., O'Shea, John J., Kaplan, Mariana J., Gadina, Massimo
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2017)
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Journal Article
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2016)
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Journal Article
Whole Chromosome Instability induces senescence and promotes SASP
Andriani, Grasiella Angelina, Almeida, Vinnycius Pereira, Faggioli, Francesca, Mauro, Maurizio, Tsai, Wanxia Li, Santambrogio, Laura, Maslov, Alexander, Gadina, Massimo, Campisi, Judith, Vijg, Jan, Montagna, Cristina
Published in Scientific reports (12.10.2016)
Published in Scientific reports (12.10.2016)
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Journal Article
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
Schwartz, Daniella M., Bonelli, Michael, Gadina, Massimo, O'Shea, John J.
Published in Nature reviews. Rheumatology (03.12.2015)
Published in Nature reviews. Rheumatology (03.12.2015)
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Journal Article
Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients
Kim, Hanna, Brooks, Kristina M, Tang, Cheng Cai, Wakim, Paul, Blake, Mary, Brooks, Stephen R, Montealegre Sanchez, Gina A, de Jesus, Adriana A, Huang, Yan, Tsai, Wanxia Li, Gadina, Massimo, Prakash, Apurva, Janes, Jonathan Marcus, Zhang, Xin, Macias, William L, Kumar, Parag, Goldbach-Mansky, Raphaela
Published in Clinical pharmacology and therapeutics (01.08.2018)
Published in Clinical pharmacology and therapeutics (01.08.2018)
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Journal Article
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
Ghoreschi, Kamran, Jesson, Michael I, Li, Xiong, Lee, Jamie L, Ghosh, Sarbani, Alsup, Jason W, Warner, James D, Tanaka, Masao, Steward-Tharp, Scott M, Gadina, Massimo, Thomas, Craig J, Minnerly, John C, Storer, Chad E, LaBranche, Timothy P, Radi, Zaher A, Dowty, Martin E, Head, Richard D, Meyer, Debra M, Kishore, Nandini, O'Shea, John J
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Journal Article
Editorial: JAK inhibition in autoimmune and inflammatory diseases
Telliez, Jean-Baptiste, Gadina, Massimo, Ghoreschi, Kamran, Silvennoinen, Olli, Spinelli, Francesca Romana
Published in Frontiers in immunology (28.12.2022)
Published in Frontiers in immunology (28.12.2022)
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Journal Article
Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies
Kim, Hanna, Gunter-Rahman, Fatima, McGrath, John A, Lee, Esther, de Jesus, Adriana A, Targoff, Ira N, Huang, Yan, O'Hanlon, Terrance P, Tsai, Wanxia L, Gadina, Massimo, Miller, Frederick W, Goldbach-Mansky, Raphaela, Rider, Lisa G
Published in Arthritis research & therapy (06.04.2020)
Published in Arthritis research & therapy (06.04.2020)
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Journal Article
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Clement, Cristina C., D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura
Published in Nature communications (21.07.2021)
Published in Nature communications (21.07.2021)
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Journal Article
Jakinibs of All Trades: Inhibiting Cytokine Signaling in Immune-Mediated Pathologies
Alexander, Madison, Luo, Yiming, Raimondi, Giorgio, O'Shea, John J, Gadina, Massimo
Published in Pharmaceuticals (Basel, Switzerland) (30.12.2021)
Published in Pharmaceuticals (Basel, Switzerland) (30.12.2021)
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Journal Article