Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8⁺ T-cell axis
Brackett, Craig M., Kojouharov, Bojidar, Veith, Jean, Greene, Kellee F., Burdelya, Lyudmila G., Gollnick, Sandra O., Abrams, Scott I., Gudkov, Andrei V.
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
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Hypoxia suppresses conversion from proliferative arrest to cellular senescence
Leontieva, Olga V, Natarajan, Venkatesh, Demidenko, Zoya N, Burdelya, Lyudmila G, Gudkov, Andrei V, Blagosklonny, Mikhail V
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
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Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
Burdelya, Lyudmila G, Krivokrysenko, Vadim I, Tallant, Thomas C, Strom, Evguenia, Gleiberman, Anatoly S, Gupta, Damodar, Kurnasov, Oleg V, Fort, Farrel L, Osterman, Andrei L, DiDonato, Joseph A, Feinstein, Elena, Gudkov, Andrei V
Published in Science (American Association for the Advancement of Science) (11.04.2008)
Published in Science (American Association for the Advancement of Science) (11.04.2008)
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TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects
Haderski, Gary J, Kandar, Bojidar M, Brackett, Craig M, Toshkov, Ilia M, Johnson, Christopher P, Paszkiewicz, Geraldine M, Natarajan, Venkatesh, Gleiberman, Anatoli S, Gudkov, Andrei V, Burdelya, Lyudmila G
Published in PloS one (06.02.2020)
Published in PloS one (06.02.2020)
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Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist
Burdelya, Lyudmila G., Brackett, Craig M., Kojouharov, Bojidar, Gitlin, Ilya I., Leonova, Katerina I., Gleiberman, Anatoli S., Aygun-Sunar, Semra, Veith, Jean, Johnson, Christopher, Haderski, Gary J., Stanhope-Baker, Patricia, Allamaneni, Shyam, Skitzki, Joseph, Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Scheblyakov, Dmitry, Artemicheva, Nataliya M., Logunov, Denis Y., Gintsburg, Alexander L., Naroditsky, Boris S., Makarov, Sergei S., Gudkov, Andrei V.
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2013)
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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
Komarova, Elena A, Gudkov, Andrei V, Strom, Evguenia, Sathe, Swati, Komarov, Pavel G, Chernova, Olga B, Pavlovska, Ivanda, Shyshynova, Inna, Bosykh, Dmitry A, Burdelya, Lyudmila G, Macklis, Roger M, Skaliter, Rami
Published in Nature chemical biology (01.09.2006)
Published in Nature chemical biology (01.09.2006)
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A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity
Leigh, Nicholas D, Bian, Guanglin, Ding, Xilai, Liu, Hong, Aygun-Sunar, Semra, Burdelya, Lyudmila G, Gudkov, Andrei V, Cao, Xuefang
Published in PloS one (14.01.2014)
Published in PloS one (14.01.2014)
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Toll-like Receptor 5 Agonist Protects Mice From Dermatitis and Oral Mucositis Caused by Local Radiation: Implications for Head-and-Neck Cancer Radiotherapy
Burdelya, Lyudmila G., Ph.D, Gleiberman, Anatoli S., Ph.D, Toshkov, Ilia, M.D., Ph.D, Aygun-Sunar, Semra, Ph.D, Bapardekar, Meghana, Ph.D, Manderscheid-Kern, Patricia, Ph.D, Bellnier, David, Ph.D, Krivokrysenko, Vadim I., Ph.D, Feinstein, Elena, M.D., Ph.D, Gudkov, Andrei V., Ph.D., D.Sci
Published in International journal of radiation oncology, biology, physics (01.05.2012)
Published in International journal of radiation oncology, biology, physics (01.05.2012)
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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications
Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.
Published in Communications biology (12.04.2021)
Published in Communications biology (12.04.2021)
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Combined Stimulation of Toll-Like Receptor 5 and NOD1 Strongly Potentiates Activity of NF-κB, Resulting in Enhanced Innate Immune Reactions and Resistance to Salmonella enterica Serovar Typhimurium Infection
Tukhvatulin, Amir I, Gitlin, Ilya I, Shcheblyakov, Dmitry V, Artemicheva, Natalia M, Burdelya, Lyudmila G, Shmarov, Maxim M, Naroditsky, Boris S, Gudkov, Andrei V, Gintsburg, Alexander L, Logunov, Denis Y
Published in Infection and Immunity (01.10.2013)
Published in Infection and Immunity (01.10.2013)
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Small Molecules That Reactivate p53 in Renal Cell Carcinoma Reveal a NF-κB-Dependent Mechanism of p53 Suppression in Tumors
Katerina V. Gurova, Hill, Jason E., Canhui Guo, Anatoly Prokvolit, Burdelya, Lyudmila G., Eugenia Samoylova, Anna V. Khodyakova, Ram Ganapathi, Mahrukh Ganapathi, Natalia D. Tararova, Dmitry Bosykh, Dmitriy Lvovskiy, Thomas R. Webb, Stark, George R., Gudkov, Andrei V.
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
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Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice
Kojouharov, Bojidar M, Brackett, Craig M, Veith, Jean M, Johnson, Christopher P, Gitlin, Ilya I, Toshkov, Ilia A, Gleiberman, Anatoli S, Gudkov, Andrei V, Burdelya, Lyudmila G
Published in Oncotarget (15.02.2014)
Published in Oncotarget (15.02.2014)
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Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9
Brackett, Craig M., Greene, Kellee F., Aldrich, Alyssa R., Trageser, Nicholas H., Pal, Srabani, Molodtsov, Ivan, Kandar, Bojidar M., Burdelya, Lyudmila G., Abrams, Scott I., Gudkov, Andrei V.
Published in Cell death discovery (28.09.2021)
Published in Cell death discovery (28.09.2021)
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Stimulation of an anti-tumor immune response with “chromatin-damaging” therapy
Chen, Minhui, Brackett, Craig M., Burdelya, Lyudmila G., Punnanitinont, Achamaporn, Patnaik, Santosh K., Matsuzaki, Junko, Odunsi, Adekunle O., Gudkov, Andrei V., Singh, Anurag K., Repasky, Elizabeth A., Gurova, Katerina V.
Published in Cancer Immunology, Immunotherapy (01.07.2021)
Published in Cancer Immunology, Immunotherapy (01.07.2021)
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Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation
Toshkov, Ilia A, Gleiberman, Anatoli S, Mett, Vadim L, Hutson, Alan D, Singh, Anurag K, Gudkov, Andrei V, Burdelya, Lyudmila G
Published in Radiation research (01.05.2017)
Published in Radiation research (01.05.2017)
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The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism
Yang, Hua, Brackett, Craig M, Morales-Tirado, Vanessa Marie, Li, Zezhong, Zhang, Qing, Wilson, Matthew W, Benjamin, Camille, Harris, Wayne, Waller, Edmund K, Gudkov, Andrei V, Burdelya, Lyudmila G, Grossniklaus, Hans E
Published in Oncotarget (19.01.2016)
Published in Oncotarget (19.01.2016)
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A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease
Ding, Xilai, Bian, Guanglin, Leigh, Nicholas D, Qiu, Jingxin, McCarthy, Philip L, Liu, Hong, Aygun-Sunar, Semra, Burdelya, Lyudmila G, Gudkov, Andrei V, Cao, Xuefang
Published in The Journal of immunology (1950) (15.11.2012)
Published in The Journal of immunology (1950) (15.11.2012)
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Secreted Transforming Growth Factor β2 Activates NF-κB, Blocks Apoptosis, and Is Essential for the Survival of Some Tumor Cells
Lu, Tao, Burdelya, Lyudmila G., Swiatkowski, Shannon M., Boiko, Alexander D., Howe, Philip H., Stark, George R., Gudkov, Andrei V.
Published in Proceedings of the National Academy of Sciences - PNAS (04.05.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (04.05.2004)
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Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice
BURDELYA, Lyudmila G, KOMAROVA, Elena A, HILL, Jason E, BROWDER, Timothy, TARAROVA, Natalia D, MAVRAKIS, Lori, DICORLETO, Paul E, FOLKMAN, Judah, GUDKOV, Andrei V
Published in Cancer research (Chicago, Ill.) (01.10.2006)
Published in Cancer research (Chicago, Ill.) (01.10.2006)
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Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity
Brackett, Craig M, Aldrich, Alyssa R, Greene, Kellee F, Kandar, Bojidar, Veith, Jean, Burdelya, Lyudmila G, Abrams, Scott I., Gudkov, Andrei V
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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