Photoswitching the Efficacy of a Small‐Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism
Gómez‐Santacana, Xavier, de Munnik, Sabrina M., Vijayachandran, Prashanna, Da Costa Pereira, Daniel, Bebelman, Jan Paul M., de Esch, Iwan J. P., Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob
Published in Angewandte Chemie International Edition (03.09.2018)
Published in Angewandte Chemie International Edition (03.09.2018)
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Journal Article
Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity
Dumazer, Anaëlle, Gómez-Santacana, Xavier, Malhaire, Fanny, Jopling, Chris, Maurel, Damien, Lebon, Guillaume, Llebaria, Amadeu, Goudet, Cyril
Published in ACS chemical neuroscience (07.02.2024)
Published in ACS chemical neuroscience (07.02.2024)
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Journal Article
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
Gómez-Santacana, Xavier, Pittolo, Silvia, Rovira, Xavier, Lopez, Marc, Zussy, Charleine, Dalton, James A. R, Faucherre, Adèle, Jopling, Chris, Pin, Jean-Philippe, Ciruela, Francisco, Goudet, Cyril, Giraldo, Jesús, Gorostiza, Pau, Llebaria, Amadeu
Published in ACS central science (25.01.2017)
Published in ACS central science (25.01.2017)
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Journal Article
A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light
Gómez-Santacana, Xavier, de Munnik, Sabrina M, Mocking, Tamara A M, Hauwert, Niels J, Sun, Shanliang, Vijayachandran, Prashanna, de Esch, Iwan J P, Vischer, Henry F, Wijtmans, Maikel, Leurs, Rob
Published in Beilstein journal of organic chemistry (23.10.2019)
Published in Beilstein journal of organic chemistry (23.10.2019)
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Journal Article
Computational Analysis of Negative and Positive Allosteric Modulator Binding and Function in Metabotropic Glutamate Receptor 5 (In)Activation
Dalton, James A. R, Gómez-Santacana, Xavier, Llebaria, Amadeu, Giraldo, Jesús
Published in Journal of chemical information and modeling (27.05.2014)
Published in Journal of chemical information and modeling (27.05.2014)
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Journal Article
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation
Gómez-Santacana, Xavier, Dalton, James A.R., Rovira, Xavier, Pin, Jean Philippe, Goudet, Cyril, Gorostiza, Pau, Giraldo, Jesús, Llebaria, Amadeu
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
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Journal Article
Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective
Dalton, James A R, Lans, Isaias, Rovira, Xavier, Malhaire, Fanny, Gómez-Santacana, Xavier, Pittolo, Silvia, Gorostiza, Pau, Llebaria, Amadeu, Goudet, Cyril, Pin, Jean-Philippe, Giraldo, Jesús
Published in Current neuropharmacology (01.07.2016)
Published in Current neuropharmacology (01.07.2016)
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Journal Article
Mechanistic Insights into Light-Driven Allosteric Control of GPCR Biological Activity
Ricart-Ortega, Maria, Berizzi, Alice E, Pereira, Vanessa, Malhaire, Fanny, Catena, Juanlo, Font, Joan, Gómez-Santacana, Xavier, Muñoz, Lourdes, Zussy, Charleine, Serra, Carmen, Rovira, Xavier, Goudet, Cyril, Llebaria, Amadeu
Published in ACS pharmacology & translational science (09.10.2020)
Published in ACS pharmacology & translational science (09.10.2020)
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Journal Article
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Nasrallah, Chady, Cannone, Giuseppe, Briot, Julie, Rottier, Karine, Berizzi, Alice E., Huang, Chia-Ying, Quast, Robert B., Hoh, Francois, Banères, Jean-Louis, Malhaire, Fanny, Berto, Ludovic, Dumazer, Anaëlle, Font-Ingles, Joan, Gómez-Santacana, Xavier, Catena, Juanlo, Kniazeff, Julie, Goudet, Cyril, Llebaria, Amadeu, Pin, Jean-Philippe, Vinothkumar, Kutti R., Lebon, Guillaume
Published in Cell reports (Cambridge) (31.08.2021)
Published in Cell reports (Cambridge) (31.08.2021)
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Journal Article
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
Pittolo, Silvia, Lee, Hyojung, Lladó, Anna, Tosi, Sébastien, Bosch, Miquel, Bardia, Lídia, Gómez-Santacana, Xavier, Llebaria, Amadeu, Soriano, Eduardo, Colombelli, Julien, Poskanzer, Kira E., Perea, Gertrudis, Gorostiza, Pau
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2019)
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Journal Article
Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
Panarello, Silvia, González-Díez, Aleix, Berizzi, Alice E., Malhaire, Fanny, Borràs-Tudurí, Roser, Rovira, Xavier, Serra, Carme, Prézeau, Laurent, Pin, Jean-Philippe, Goudet, Cyril, Llebaria, Amadeu, Gómez-Santacana, Xavier
Published in iScience (21.06.2024)
Published in iScience (21.06.2024)
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Journal Article
Photoswitchable allosteric modulators for metabotropic glutamate receptors
Gómez-Santacana, Xavier, Panarello, Silvia, Rovira, Xavier, Llebaria, Amadeu
Published in Current opinion in pharmacology (01.10.2022)
Published in Current opinion in pharmacology (01.10.2022)
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Journal Article
Photoswitching the Efficacy of a Small‐Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism
Gómez‐Santacana, Xavier, de Munnik, Sabrina M., Vijayachandran, Prashanna, Da Costa Pereira, Daniel, Bebelman, Jan Paul M., de Esch, Iwan J. P., Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob
Published in Angewandte Chemie (03.09.2018)
Published in Angewandte Chemie (03.09.2018)
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Journal Article
An allosteric modulator to control endogenous G protein-coupled receptors with light
Pittolo, Silvia, Gómez-Santacana, Xavier, Eckelt, Kay, Rovira, Xavier, Dalton, James, Goudet, Cyril, Pin, Jean-Philippe, Llobet, Artur, Giraldo, Jesús, Llebaria, Amadeu, Gorostiza, Pau
Published in Nature chemical biology (01.10.2014)
Published in Nature chemical biology (01.10.2014)
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Journal Article
A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
Notartomaso, Serena, Antenucci, Nico, Mazzitelli, Mariacristina, Rovira, Xavier, Boccella, Serena, Ricciardi, Flavia, Liberatore, Francesca, Gomez-Santacana, Xavier, Imbriglio, Tiziana, Cannella, Milena, Zussy, Charleine, Luongo, Livio, Maione, Sabatino, Goudet, Cyril, Battaglia, Giuseppe, Llebaria, Amadeu, Nicoletti, Ferdinando, Neugebauer, Volker
Published in eLife (22.08.2024)
Published in eLife (22.08.2024)
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Journal Article
Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity
Dumazer, Anaëlle, Gómez-Santacana, Xavier, Malhaire, Fanny, Jopling, Chris, Maurel, Damien, Lebon, Guillaume, Llebaria, Amadeu, Goudet, Cyril
Published in ACS chemical neuroscience (07.02.2024)
Published in ACS chemical neuroscience (07.02.2024)
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Journal Article
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation
Gómez-Santacana, Xavier, Dalton, James A R, Rovira, Xavier, Pin, Jean Philippe, Goudet, Cyril, Gorostiza, Pau, Giraldo, Jesús, Llebaria, Amadeu
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
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Journal Article