ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia
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The Macromolecular Basis of Phytoplankton C:N:P Under Nitrogen Starvation
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A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease
Taylor, Mike, Ousler, George, Torkildsen, Gail, Walshe, Claire, Fyfe, Matthew C T, Rowley, Adele, Webber, Steve, Sheppard, John D, Duggal, Ajay
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Latitudinal patterns in ocean C:N:P reflect phytoplankton acclimation and macromolecular composition
Liefer, Justin D., White, Angelicque E., Finkel, Zoe V., Irwin, Andrew J., Dugenne, Mathilde, Inomura, Keisuke, Ribalet, François, Armbrust, E. Virginia, Karl, David M., Fyfe, Matthew H., Brown, Christopher M., Follows, Michael J.
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.2024)
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Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders
Hagan, Suzanne, Fyfe, Matthew C T, Ofori-Frimpong, Boatemaa, Oliver, Katherine, Foster, Martyn R, Sirohi, Sameer, Solanke, Yemisi, Doughty, Michael, Rowley, Adele, Taylor, Mike, Webber, Steve, Walshe, Claire A
Published in Investigative ophthalmology & visual science (01.03.2018)
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Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations
Maes, Tamara, Mascaró, Cristina, Rotllant, David, Lufino, Michele Matteo Pio, Estiarte, Angels, Guibourt, Nathalie, Cavalcanti, Fernando, Griñan-Ferré, Christian, Pallàs, Mercè, Nadal, Roser, Armario, Antonio, Ferrer, Isidro, Ortega, Alberto, Valls, Nuria, Fyfe, Matthew, Martinell, Marc, Castro Palomino, Julio César, Buesa Arjol, Carlos
Published in PloS one (29.05.2020)
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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
Overton, Hilary A., Babbs, Adam J., Doel, Sheila M., Fyfe, Matthew C.T., Gardner, Lisa S., Griffin, Graeme, Jackson, Helen C., Procter, Martin J., Rasamison, Chrystelle M., Tang-Christensen, Mads, Widdowson, Peter S., Williams, Geoffery M., Reynet, Christine
Published in Cell metabolism (01.03.2006)
Published in Cell metabolism (01.03.2006)
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Phospho-Flow Cytometry: A Method for Investigating Effects of Narrow Spectrum Kinase Inhibitors on Kinase Phosphorylation as a Clinical Biomarker
Sirohi, Sameer, Foster, Martyn, Fyfe, Matthew C, Solanke, Yemisi, Webber, Steve, Walshe, Claire A
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis
Biancheri, Paolo, Foster, Martyn R, Fyfe, Matthew C T, MacDonald, Thomas T, Sirohi, Sameer, Solanke, Yemisi, Wood, Eleanor, Rowley, Adele, Webber, Steve, Walshe, Claire A
Published in Inflammatory bowel diseases (01.06.2016)
Published in Inflammatory bowel diseases (01.06.2016)
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The Narrow Spectrum Kinase Inhibitor (NSKI) TOP1288 Demonstrates Potent Anti-Inflammatory Effects in a T Cell Adoptive Transfer Colitis Model Through a Topical Mode of Action
Solanke, Yemisi, Foster, Martyn, Fyfe, Matthew C, Rowley, Adele, Sirohi, Sameer, Webber, Steve, Walshe, Claire A
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)-N-thiazol-2-ylacetamides: Discovery of PSN-GK1
Bertram, Lisa S, Black, Daniel, Briner, Paul H, Chatfield, Rosemary, Cooke, Andrew, Fyfe, Matthew C. T, Murray, P. John, Naud, Frédéric, Nawano, Masao, Procter, Martin J, Rakipovski, Günaj, Rasamison, Chrystelle M, Reynet, Christine, Schofield, Karen L, Shah, Vilas K, Spindler, Felix, Taylor, Amanda, Turton, Roy, Williams, Geoffrey M, Wong-Kai-In, Philippe, Yasuda, Kosuke
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Tu1880 TOP1210 NSKI Demonstrates Superior Activity and Improved Safety Profile Potential Compared to Corticosteroid and Immunomodulators in Preclinical Models of Colitis
Walshe, Claire A, Rowley, Adele, Foster, Martyn, Solanke, Yemisi, Sirohi, Sameer, Fyfe, Matthew C, Webber, Steve
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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The Pharmacological Profile of TOP1288, a Narrow Spectrum Kinase Inhibitor (NSKI) in Clinical Development as an Anti-Inflammatory Treatment for Ulcerative Colitis
Foster, Martyn, Biancheri, Paolo, Fyfe, Matthew C, MacDonald, Thomas T, Rowley, Adele, Sirohi, Sameer, Solanke, Yemisi, Webber, Steve, Walshe, Claire A
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Sa1855 Inhibition of Cytokine Release From HT-29 Cells and Ulcerative Colitis Biopsies Is Potentiated by Combination of Selective Kinase Inhibitors and Such Effects Are Mimicked by TOP1210, a Narrow Spectrum Kinase Inhibitor (NSKIi)
Foster, Martyn, Biancheri, Paolo, Sirohi, Sameer, Solanke, Yemisi, Fyfe, Matthew C, Rowley, Adele, MacDonald, Thomas T, Wood, Eleanor, Webber, Steve, Walshe, Claire A
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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Sa1854 Effects of a Narrow Spectrum Kinase Inhibitor (NSKI) and Selective Kinase Inhibitors on the Intestinal Pro-Inflammatory Immune Response in Ulcerative Colitis
Foster, Martyn, Biancheri, Paolo, Solanke, Yemisi, Sirohi, Sameer, Fyfe, Matthew C, Rowley, Adele, MacDonald, Thomas T, Wood, Eleanor, Webber, Steve, Walshe, Claire A
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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Acid−Base Controllable Molecular Shuttles
Ashton, Peter R, Ballardini, Roberto, Balzani, Vincenzo, Baxter, Ian, Credi, Alberto, Fyfe, Matthew C. T, Gandolfi, Maria Teresa, Gómez-López, Marcos, Martínez-Díaz, M.-Victoria, Piersanti, Arianna, Spencer, Neil, Stoddart, J. Fraser, Venturi, Margherita, White, Andrew J. P, Williams, David J
Published in Journal of the American Chemical Society (25.11.1998)
Published in Journal of the American Chemical Society (25.11.1998)
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A Three-Pole Supramolecular Switch
Ashton, Peter R, Balzani, Vincenzo, Becher, Jan, Credi, Alberto, Fyfe, Matthew C. T, Mattersteig, Gunter, Menzer, Stephan, Nielsen, Mogens B, Raymo, Françisco M, Stoddart, J. Fraser, Venturi, Margherita, Williams, David J
Published in Journal of the American Chemical Society (28.04.1999)
Published in Journal of the American Chemical Society (28.04.1999)
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Ashton, Peter R, Baxter, Ian, Fyfe, Matthew C. T, Raymo, Françisco M, Spencer, Neil, Stoddart, J. Fraser, White, Andrew J. P, Williams, David J
Published in Journal of the American Chemical Society (18.03.1998)
Published in Journal of the American Chemical Society (18.03.1998)
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