Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes
Jacobson, Peer B, von Geldern, Thomas W, Ohman, Lars, Osterland, Marie, Wang, Jiahong, Zinker, Bradley, Wilcox, Denise, Nguyen, Phong T, Mika, Amanda, Fung, Steven, Fey, Thomas, Goos-Nilsson, Annika, Grynfarb, Marlena, Barkhem, Tomas, Marsh, Kennan, Beno, David W A, Nga-Nguyen, Bach, Kym, Philip R, Link, James T, Tu, Noah, Edgerton, Dale S, Cherrington, Alan, Efendic, Suad, Lane, Benjamin C, Opgenorth, Terry J
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes
von Geldern, Thomas W, Tu, Noah, Kym, Philip R, Link, James T, Jae, Hwan-Soo, Lai, Chunqiu, Apelqvist, Theresa, Rhonnstad, Patrik, Hagberg, Lars, Koehler, Konrad, Grynfarb, Marlena, Goos-Nilsson, Annika, Sandberg, Johnny, Österlund, Marie, Barkhem, Tomas, Höglund, Marie, Wang, Jiahong, Fung, Steven, Wilcox, Denise, Nguyen, Phong, Jakob, Clarissa, Hutchins, Charles, Färnegårdh, Mathias, Kauppi, Björn, Öhman, Lars, Jacobson, Peer B
Published in Journal of medicinal chemistry (12.08.2004)
Published in Journal of medicinal chemistry (12.08.2004)
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The synthesis of oligonucleotides containing an aliphatic amino group at the 5′ terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis
Smith, Lloyd M., Fung, Steven, Hunkapiller, Michael W., Hunkapiller, Tim J., Hood, Leroy E.
Published in Nucleic acids research (11.04.1985)
Published in Nucleic acids research (11.04.1985)
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Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
Rohde, Jeffrey J, Pliushchev, Marina A, Sorensen, Bryan K, Wodka, Dariusz, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina M, Chiou, William J, Pan, Liping, Deng, Xiaoqing, Chovan, Linda E, Ramaiya, Atul, Mullally, Mark, Henry, Rodger F, Stolarik, DeAnne F, Imade, Hovis M, Marsh, Kennan C, Beno, David W. A, Fey, Thomas A, Droz, Brian A, Brune, Michael E, Camp, Heidi S, Sham, Hing L, Frevert, Ernst Uli, Jacobson, Peer B, Link, J. T
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors
Sorensen, Bryan, Winn, Martin, Rohde, Jeff, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Stolarik, DeAnne, Imade, Hovis, Pan, Liping, Deng, Xiaoqing, Chovan, Linda, Longenecker, Kenton, Judge, Russell, Qin, Wenying, Brune, Michael, Camp, Heidi, Frevert, Ernst U., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction
Sorensen, Bryan, Rohde, Jeff, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Pan, Liping, Deng, Xiaoqing, Stolarik, DeAnne, Frevert, Ernst U., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S.C., Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R., Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L., Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation
Patel, Jyoti R., Shuai, Qi, Dinges, Jurgen, Winn, Marty, Pliushchev, Marina, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Pan, Liping, Wagaw, Seble, Engstrom, Kenneth, Kerdesky, Francis A., Longenecker, Kenton, Judge, Russell, Qin, Wenying, Imade, Hovis M., Stolarik, DeAnne, Beno, David W.A., Brune, Michael, Chovan, Linda E., Sham, Hing L., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors
Yeh, Vince S.C., Patel, Jyoti R., Yong, Hong, Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Beno, David, Brune, Michael, Jacobson, Peer, Sham, Hing, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Journal Article
Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
Richards, Steven, Sorensen, Bryan, Jae, Hwan-soo, Winn, Marty, Chen, Yixian, Wang, Jiahong, Fung, Steven, Monzon, Katina, Frevert, Ernst U., Jacobson, Peer, Sham, Hing, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
Discovery of orally active butyrolactam 11β-HSD1 inhibitors
Yeh, Vince S.C., Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Shapiro, Robin, Knourek-Segel, Victoria, Bush, Eugene, Wilcox, Denise, Nguyen, Phong T., Brune, Michael, Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Journal Article
Antidiabetic Activity of Passive Nonsteroidal Glucocorticoid Receptor Modulators
Link, J. T, Sorensen, Bryan, Patel, Jyoti, Grynfarb, Marlena, Goos-Nilsson, Annika, Wang, Jiahong, Fung, Steven, Wilcox, Denise, Zinker, Brad, Nguyen, Phong, Hickman, Bach, Schmidt, James M, Swanson, Sue, Tian, Zhenping, Reisch, Thomas J, Rotert, Gary, Du, Jia, Lane, Benjamin, von Geldern, Thomas W, Jacobson, Peer B
Published in Journal of medicinal chemistry (11.08.2005)
Published in Journal of medicinal chemistry (11.08.2005)
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Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists
Backes, Bradley J., Hamilton, Gregory L., Nguyen, Phong, Wilcox, Denise, Fung, Steven, Wang, Jiahong, Grynfarb, Marlena, Goos-Nilsson, Annika, Jacobson, Peer B., von Geldern, Thomas W.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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