Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Journal Article
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity
Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Journal Article
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy
Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase
Mortensen, Deborah S., Sapienza, John, Lee, Branden G.S., Perrin-Ninkovic, Sophie M., Harris, Roy, Shevlin, Graziella, Parnes, Jason S., Whitefield, Brandon, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Peng, Sophie, Gamez, Jim C., Leisten, Jim, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Pronounced Reduction in Adenoma Recurrence Associated with Aspirin Use and a Polymorphism in the Ornithine Decarboxylase Gene
Martínez, María Elena, O'Brien, Thomas G., Fultz, Kimberly E., Babbar, Naveen, Yerushalmi, Hagit, Qu, Ning, Guo, Yongjun, Boorman, David, Einspahr, Janine, Alberts, David S., Gerner, Eugene W.
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2003)
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Journal Article
Discovery and SAR exploration of a novel series of imidazo[4,5- b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Harris, Roy, Lee, Branden G.S., Shevlin, Graziella, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc
Roy, Upal K. Basu, Henkhaus, Rebecca S., Ignatenko, Natalia A., Mora, Jessica, Fultz, Kimberly E., Gerner, Eugene W.
Published in Molecular carcinogenesis (01.12.2008)
Published in Molecular carcinogenesis (01.12.2008)
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Journal Article
Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase
Ennis, Bruce W, Fultz, Kimberly E, Smith, Kent A, Westwick, John K, Zhu, Dan, Boluro-Ajayi, Michael, Bilter, Graham K, Stein, Bernd
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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Journal Article
보체 인자 B-조절 조성물 및 이의 사용 방법
CORREIA JEAN DA SILVA, ZHU RUI, FULTZ KIMBERLY, LI ZHEN, ZHOU ZHIQING (JOEL), STUDER SEAN
Year of Publication 09.07.2024
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Year of Publication 09.07.2024
Patent
ADAR 의존성 편집 조성물 및 그의 사용 방법
ZHU RUI, FULTZ KIMBERLY, LI ZHEN, LEAR SAM, STUDER SEAN, DA SILVA CORREIA JEAN
Year of Publication 03.05.2023
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Year of Publication 03.05.2023
Patent
TOR TREATMENT OF PROSTATE CANCER WITH TOR KINASE INHIBITORS
HEGE KRISTEN MAE, TSUJI TOSHIYA, NARLA RAMA K, MORTENSEN DEBORAH, FULTZ KIMBERLY ELIZABETH, RAYMON HEATHER
Year of Publication 21.09.2020
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Year of Publication 21.09.2020
Patent
Abstract A165: Antitumor activity of mTOR kinase inhibitor CC-223 in a mouse model of prostate cancer
Narla, Rama Krishna, Peng, Sophie, Gamez, Jim, Katz, Jason, Apuy, Julius, Moghaddam, Mehran, Fultz, Kimberly E., Sankar, Sabita, Mortensen, Deborah S., Raymon, Heather K.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
TREATMENT OF PROSTATE CANCER WITH TOR KINASE INHIBITORS
HEGE KRISTEN MAE, TSUJI TOSHIYA, NARLA RAMA K, MORTENSEN DEBORAH, FULTZ KIMBERLY ELIZABETH, RAYMON HEATHER
Year of Publication 24.06.2015
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Year of Publication 24.06.2015
Patent
3 mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/Akt PATHWAY
ZHAO JINGJING, HARRIS ROY L, FULTZ KIMBERLY, LEE BRANDEN, SANKAR SABITA, SHEVLIN GRAZIELLA, PACKARD GARRICK, PERRIN NINKOVIC SOPHIE, SAPIENZA JOHN, RIGGS JENNIFER, NARLA RAMA K, MADAKAMUTIL LOUI, PAPA PATRICK, ELSNER JAN, MORTENSEN DEBORAH, PARNES JASON, XU WEIMING, TEHRANI LIDA
Year of Publication 12.07.2017
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Year of Publication 12.07.2017
Patent