Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain
Abbasi, Saed, Uchida, Satoshi, Toh, Kazuko, Tockary, Theofilus A., Dirisala, Anjaneyulu, Hayashi, Kotaro, Fukushima, Shigeto, Kataoka, Kazunori
Published in Journal of controlled release (10.04.2021)
Published in Journal of controlled release (10.04.2021)
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Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors
Anraku, Yasutaka, Kishimura, Akihiro, Kamiya, Mako, Tanaka, Sayaka, Nomoto, Takahiro, Toh, Kazuko, Matsumoto, Yu, Fukushima, Shigeto, Sueyoshi, Daiki, Kano, Mitsunobu R., Urano, Yasuteru, Nishiyama, Nobuhiro, Kataoka, Kazunori
Published in Angewandte Chemie International Edition (11.01.2016)
Published in Angewandte Chemie International Edition (11.01.2016)
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In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Watanabe, Sumiyo, Hayashi, Kotaro, Toh, Kazuko, Kim, Hyun Jin, Liu, Xueying, Chaya, Hiroyuki, Fukushima, Shigeto, Katsushima, Keisuke, Kondo, Yutaka, Uchida, Satoshi, Ogura, Satomi, Nomoto, Takahiro, Takemoto, Hiroyasu, Cabral, Horacio, Kinoh, Hiroaki, Tanaka, Hiroyoshi Y., Kano, Mitsunobu R., Matsumoto, Yu, Fukuhara, Hiroshi, Uchida, Shunya, Nangaku, Masaomi, Osada, Kensuke, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori
Published in Nature communications (24.04.2019)
Published in Nature communications (24.04.2019)
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Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models
Panagi, Myrofora, Mpekris, Fotios, Chen, Pengwen, Voutouri, Chrysovalantis, Nakagawa, Yasuhiro, Martin, John D., Hiroi, Tetsuro, Hashimoto, Hiroko, Demetriou, Philippos, Pierides, Chryso, Samuel, Rekha, Stylianou, Andreas, Michael, Christina, Fukushima, Shigeto, Georgiou, Paraskevi, Papageorgis, Panagiotis, Papaphilippou, Petri Ch, Koumas, Laura, Costeas, Paul, Ishii, Genichiro, Kojima, Motohiro, Kataoka, Kazunori, Cabral, Horacio, Stylianopoulos, Triantafyllos
Published in Nature communications (22.11.2022)
Published in Nature communications (22.11.2022)
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Journal Article
Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer
Nomoto, Takahiro, Fukushima, Shigeto, Kumagai, Michiaki, Machitani, Kaori, Arnida, Matsumoto, Yu, Oba, Makoto, Miyata, Kanjiro, Osada, Kensuke, Nishiyama, Nobuhiro, Kataoka, Kazunori
Published in Nature communications (02.04.2014)
Published in Nature communications (02.04.2014)
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Journal Article
In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle
Uchida, Satoshi, Itaka, Keiji, Uchida, Hirokuni, Hayakawa, Kentaro, Ogata, Toru, Ishii, Takehiko, Fukushima, Shigeto, Osada, Kensuke, Kataoka, Kazunori
Published in PloS one (13.02.2013)
Published in PloS one (13.02.2013)
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Journal Article
Targeted Polymeric Micelles for siRNA Treatment of Experimental Cancer by Intravenous Injection
Christie, R. James, Matsumoto, Yu, Miyata, Kanjiro, Nomoto, Takahiro, Fukushima, Shigeto, Osada, Kensuke, Halnaut, Julien, Pittella, Frederico, Kim, Hyun Jin, Nishiyama, Nobuhiro, Kataoka, Kazunori
Published in ACS nano (26.06.2012)
Published in ACS nano (26.06.2012)
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Journal Article
Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors
Oe, Yusuke, Christie, R. James, Naito, Mitsuru, Low, Stewart A, Fukushima, Shigeto, Toh, Kazuko, Miura, Yutaka, Matsumoto, Yu, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori
Published in Biomaterials (01.09.2014)
Published in Biomaterials (01.09.2014)
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Journal Article
Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment
Aini, Hailati, Itaka, Keiji, Fujisawa, Ayano, Uchida, Hirokuni, Uchida, Satoshi, Fukushima, Shigeto, Kataoka, Kazunori, Saito, Taku, Chung, Ung-il, Ohba, Shinsuke
Published in Scientific reports (05.01.2016)
Published in Scientific reports (05.01.2016)
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Nanomedicines Eradicating Cancer Stem-like Cells in Vivo by pH-Triggered Intracellular Cooperative Action of Loaded Drugs
Kinoh, Hiroaki, Miura, Yutaka, Chida, Tsukasa, Liu, Xueying, Mizuno, Kazue, Fukushima, Shigeto, Morodomi, Yosuke, Nishiyama, Nobuhiro, Cabral, Horacio, Kataoka, Kazunori
Published in ACS nano (28.06.2016)
Published in ACS nano (28.06.2016)
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Journal Article
Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)‑b‑poly(l‑lysine)
Chaya, Hiroyuki, Naito, Mitsuru, Cho, Masaru, Toh, Kazuko, Hayashi, Kotaro, Fukushima, Shigeto, Yamasaki, Yuichi, Kataoka, Kazunori, Miyata, Kanjiro
Published in Biomacromolecules (10.01.2022)
Published in Biomacromolecules (10.01.2022)
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Journal Article
Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine)
Naito, Mitsuru, Chaya, Hiroyuki, Toh, Kazuko, Kim, Beob Soo, Hayashi, Kotaro, Fukushima, Shigeto, Nagata, Tetsuya, Yokota, Takanori, Kataoka, Kazunori, Miyata, Kanjiro
Published in Journal of controlled release (10.02.2021)
Published in Journal of controlled release (10.02.2021)
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Journal Article
In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy
Nomoto, Takahiro, Matsumoto, Yu, Miyata, Kanjiro, Oba, Makoto, Fukushima, Shigeto, Nishiyama, Nobuhiro, Yamasoba, Tatsuya, Kataoka, Kazunori
Published in Journal of controlled release (30.04.2011)
Published in Journal of controlled release (30.04.2011)
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Journal Article
Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines
Dirisala, Anjaneyulu, Uchida, Satoshi, Toh, Kazuko, Li, Junjie, Osawa, Shigehito, Tockary, Theofilus A, Liu, Xueying, Abbasi, Saed, Hayashi, Kotaro, Mochida, Yuki, Fukushima, Shigeto, Kinoh, Hiroaki, Osada, Kensuke, Kataoka, Kazunori
Published in Science advances (01.06.2020)
Published in Science advances (01.06.2020)
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Journal Article
Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid To Eradicate Cancer Stem-like Cells
Khan, Thahomina, Igarashi, Kazunori, Tanabe, Ami, Miyazawa, Taiki, Fukushima, Shigeto, Miura, Yutaka, Matsumoto, Yu, Yamasoba, Tatsuya, Matsumoto, Akira, Cabral, Horacio, Kataoka, Kazunori
Published in ACS applied bio materials (17.08.2020)
Published in ACS applied bio materials (17.08.2020)
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Journal Article
Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle
Goto, Akinori, Yen, Hung-Chi, Anraku, Yasutaka, Fukushima, Shigeto, Lai, Ping-Shan, Kato, Masaru, Kishimura, Akihiro, Kataoka, Kazunori
Published in ACS biomaterials science & engineering (08.05.2017)
Published in ACS biomaterials science & engineering (08.05.2017)
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Journal Article
Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors
Anraku, Yasutaka, Kishimura, Akihiro, Kamiya, Mako, Tanaka, Sayaka, Nomoto, Takahiro, Toh, Kazuko, Matsumoto, Yu, Fukushima, Shigeto, Sueyoshi, Daiki, Kano, Mitsunobu R., Urano, Yasuteru, Nishiyama, Nobuhiro, Kataoka, Kazunori
Published in Angewandte Chemie (11.01.2016)
Published in Angewandte Chemie (11.01.2016)
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