Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
Erion, Mark D, Cable, Edward E, Ito, Bruce R, Jiang, Hongjian, Fujitaki, James M, Finn, Patricia D, Zhang, Bao-Hong, Hou, Jinzhao, Boyer, Serge H, van Poelje, Paul D, Linemeyer, David L
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2007)
Get full text
Journal Article
Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes
Dang, Qun, Kasibhatla, Srinivas Rao, Reddy, K. Raja, Jiang, Tao, Reddy, M. Rami, Potter, Scott C, Fujitaki, James M, van Poelje, Paul D, Huang, Jingwei, Lipscomb, William N, Erion, Mark D
Published in Journal of the American Chemical Society (19.12.2007)
Published in Journal of the American Chemical Society (19.12.2007)
Get full text
Journal Article
Liver-Targeted Drug Delivery Using HepDirect Prodrugs
Erion, Mark D, van Poelje, Paul D, Mackenna, Deidre A, Colby, Timothy J, Montag, Annika C, Fujitaki, James M, Linemeyer, David L, Bullough, David A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2005)
Get full text
Journal Article
Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees
CARROLL, Steven S, KOEPLINGER, Kenneth, FUJITAKI, James M, BOYER, Serge H, LINEMEYER, David L, HECKER, Scott J, ERION, Mark D, VAVREK, Marissa, NANYAN RENA ZHANG, HANDT, Laurence, MACCOSS, Malcolm, OLSEN, David B, RAJA REDDY, K, ZHILI SUN, VAN POELJE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Get full text
Journal Article
Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist
Fujitaki, James M, Cable, Edward E, Ito, Bruce R, Zhang, Bao-Hong, Hou, Jinzhao, Yang, Chun, Bullough, David A, Ferrero, James L, van Poelje, Paul D, Linemeyer, David L, Erion, Mark D
Published in Drug metabolism and disposition (01.11.2008)
Published in Drug metabolism and disposition (01.11.2008)
Get full text
Journal Article
Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B
Reddy, K. Raja, Matelich, Michael C, Ugarkar, Bheemarao G, Gómez-Galeno, Jorge E, DaRe, Jay, Ollis, Kristin, Sun, Zhili, Craigo, William, Colby, Timothy J, Fujitaki, James M, Boyer, Serge H, van Poelje, Paul D, Erion, Mark D
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
Get full text
Journal Article
Discovery of Phosphonic Diamide Prodrugs and Their Use for the Oral Delivery of a Series of Fructose 1,6-Bisphosphatase Inhibitors
Dang, Qun, Kasibhatla, Srinivas Rao, Jiang, Tao, Fan, Kevin, Liu, Yan, Taplin, Frank, Schulz, William, Cashion, Daniel K, Reddy, K. Raja, van Poelje, Paul D, Fujitaki, James M, Potter, Scott C, Erion, Mark D
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
Get full text
Journal Article
Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs
Boyer, Serge H, Jiang, Hongjian, Jacintho, Jason D, Reddy, Mali Venkat, Li, Haiqing, Li, Wenyu, Godwin, Jennifer L, Schulz, William G, Cable, Edward E, Hou, Jinzhao, Wu, Rongrong, Fujitaki, James M, Hecker, Scott J, Erion, Mark D
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection
Hecker, Scott J, Reddy, K. Raja, van Poelje, Paul D, Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M, Olsen, David B, Koeplinger, Kenneth A, Boyer, Serge H, Linemeyer, David L, MacCoss, Malcolm, Erion, Mark D
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
Get full text
Journal Article
Synthesis and evaluation of 5-amino-1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase
Sanghvi, Yogesh S, Hanna, Naeem B, Larson, Steven B, Fujitaki, James M, Willis, Randall C, Smith, Roberts A, Robins, Roland K, Revankar, Ganapathi R
Published in Journal of medicinal chemistry (01.02.1988)
Published in Journal of medicinal chemistry (01.02.1988)
Get full text
Journal Article
Covalent linkage of phospholipid to myelin basic protein: identification of phosphatidylinositol bisphosphate as the attached phospholipid
Yang, Jen Chen, Chang, Paul Changtung, Fujitaki, James M, Chiu, Ken C, Smith, Roberts A
Published in Biochemistry (Easton) (01.05.1986)
Published in Biochemistry (Easton) (01.05.1986)
Get full text
Journal Article
1143 MB6866 (Hepavir B), a HepDirect™ prodrug of adefovir: mechanism of activation and liver targeting
van Poelje, Paul D., Colby, Timothy J., Fujitaki, James M., Reddy, K. Raja, Matelich, Michael C., Senekeo, Kathy A., Linemeyer, David L., Erion, Mark D.
Published in Hepatology (Baltimore, Md.) (2003)
Published in Hepatology (Baltimore, Md.) (2003)
Get full text
Journal Article
Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes
Dang, Qun, Kasibhatla, Srinivas Rao, Reddy, KRaja, Jiang, Tao, Reddy, MRami, Potter, Scott C, Fujitaki, James M, Van Poelje, Paul D, Huang, Jingwei, Lipscomb, William N, Erion, Mark D
Published in Journal of the American Chemical Society (01.01.2007)
Published in Journal of the American Chemical Society (01.01.2007)
Get full text
Journal Article
Design, synthesis, and structure-activity relationships of the first highly potent, selective, and bioavailable adenosine 5'-monophosphate deaminase inhibitors
Kasibhatla, S R, Bookser, B C, Appleman, J R, Probst, G, Xiao, W, Fujitaki, J M, Erion, M D
Published in Advances in experimental medicine and biology (1998)
Published in Advances in experimental medicine and biology (1998)
Get more information
Journal Article
A sensitive assay for the aminoimidazole-containing drug GP531 in plasma using liquid chromatography with amperometric electrochemical detection: a new class of electroactive compounds
Chen, Long-Shiuh, Fujitaki, James M., Dixon, Ross
Published in Journal of pharmaceutical and biomedical analysis (01.08.1996)
Published in Journal of pharmaceutical and biomedical analysis (01.08.1996)
Get full text
Journal Article